ISCHEMOL EYE DROPS

Chloramphenicol is a broad-spectrum antibiotic that inhibits bacterial protein synthesis by binding to the 50S subunit of the bacterial ribosome. It interferes with the peptidyl transferase activity, preventing the addition of new amino acids to the growing peptide chain. This action leads to the disruption of bacterial cell wall synthesis and ultimately results in bacterial cell death. Tetrahydrozoline, on the other hand, is a sympathomimetic amine that acts as a vasoconstrictor. It primarily exerts its effect by stimulating alpha-adrenergic receptors in the blood vessels of the eye, causing constriction of the blood vessels and reducing redness and inflammation. This mechanism helps to alleviate ocular symptoms by decreasing blood flow to the site of irritation.

Chloramphenicol, Tetrahydrozoline

Antibiotic and Vasoconstrictor

Drop

The following are the uses of Chloramphenicol, Tetrahydrozoline Drop:

• Used for treating eye infections and reducing inflammation
• Used for bacterial conjunctivitis, a common eye infection
• Used to provide relief from eye redness and irritation
• Used in post-operative eye care to prevent infection and promote healing
• Used for eye allergies, reducing itching and swelling
• Used to prevent and treat eye infections in newborns
• Used for minor eye injuries, aiding in recovery
• Used to prevent and control bacterial eye infections

In the case of an overdose of Chloramphenicol, symptoms may include bone marrow suppression, nausea, and vomiting. Prompt medical care is necessary. For Tetrahydrozoline eye drops, overdose can lead to severe drowsiness, slow breathing, and coma. Rinse the eyes with water and seek emergency medical assistance immediately. Always follow the prescribed dosage and consult a healthcare professional for specific guidance.

In the case of a missed dose of Chloramphenicol, administer the eye drops as soon as you remember, but if it's almost time for the next dose, skip the missed dose and continue with your regular schedule. For Tetrahydrozoline drops, if you miss a dose, take it as soon as you remember, but if it's close to the time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one.

To use Chloramphenicol and Tetrahydrozoline eye drops, gently tilt your head back, pull the lower eyelid down to create a pocket, and instill the prescribed number of drops into the eye. Look downward and gently close your eyes for 1-2 minutes to allow the medication to be absorbed. Wash your hands before and after use, and avoid touching the dropper tip to prevent contamination.

Following are the conditions/situations when Chloramphenicol, Tetrahydrozoline Drops should not be used:

• Avoid using these drops if you have a known allergy or hypersensitivity to Chloramphenicol or Tetrahydrozoline, or any other ingredients in the eye drop formulation.
• Do not use if you have a bacterial or viral eye infection, especially those caused by herpes simplex (cold sores or genital herpes).
• Not suitable for individuals with a history of eye injuries or recent eye surgery.
• Should not be used if you have thin or damaged corneas.
• Contraindicated in individuals with a condition called 'dry eye syndrome'.
• Avoid using these drops if you have a narrow-angle glaucoma or a tendency to develop glaucoma.
• Not recommended for infants or young children without medical advice.
• Do not use if the seal is broken or the solution appears discolored or cloudy.

The side effects of Chloramphenicol may include:

• Nausea and vomiting
• Diarrhea
• Stomach pain
• Skin rashes or itching
• Grey-baby syndrome (in newborns)
• Blood disorders (e.g., aplastic anemia)
• Headache
• Dizziness
• Eye stinging or burning
• Increased redness or irritation of the eyes
• Headache
• Dizziness
• Blurred vision
• Allergic reactions (e.g., skin rash, itching, swelling)
• Increased eye pressure (with prolonged use)

Following are the precautions and warnings for Chloramphenicol, Tetrahydrozoline Eye Drops:

• Do not use these eye drops if you are allergic to any of their ingredients, including chloramphenicol or tetrahydrozoline.
• If you wear contact lenses, remove them before using the drops and wait at least 15 minutes after application before reinserting them.
• Avoid driving or operating heavy machinery immediately after using the drops, as they may cause temporary blurred vision.
• Do not touch the dropper tip to any surface, including the eye, to avoid contamination.
• If you have or have ever had a blood disorder, liver disease, or kidney disease, consult your doctor before using these drops.
• Prolonged use of these eye drops may result in bacterial resistance or increased risk of infection.
• Keep out of reach of children. Store at room temperature and away from direct sunlight.

Following are the drug interactions for Chloramphenicol, Tetrahydrozoline Drop:

• Chloramphenicol may reduce the effectiveness of live vaccines, and the use of live vaccines should be avoided during and shortly after Chloramphenicol treatment.
• Alcohol-based eye drops can cause irritation and should be avoided while using Tetrahydrozoline.
• Concomitant use with other topical ophthalmic medications may increase the risk of adverse effects.
• It can interact with systemic medications that affect the central nervous system, potentially enhancing their effects.
• Anticoagulants like warfarin may have increased effects when used with Tetrahydrozoline, requiring close monitoring.
• Chloramphenicol can inhibit the metabolism of some medications, leading to increased blood levels and potential side effects.
• Drugs that affect the liver's enzyme system may alter the metabolism and effectiveness of Chloramphenicol.

Following are the food interactions for Chloramphenicol and Tetrahydrozoline Drops:

• Chloramphenicol may reduce the absorption of folic acid, so consuming foods rich in folate like leafy greens, beans, and fortified cereals is recommended.
• Alcohol can increase the risk of side effects and drowsiness with Chloramphenicol, hence it should be avoided.
• Grapefruit juice can decrease the elimination of Chloramphenicol, leading to higher levels in the body, so it should be consumed with caution.
• Tetrahydrozoline drops may cause a dry mouth, so drinking plenty of water and staying hydrated is essential.
• Consuming spicy foods or citrus fruits may increase eye irritation when using Tetrahydrozoline drops.
• Avoid caffeine and alcohol as they can intensify the side effects of Tetrahydrozoline, such as increased eye redness and dryness.
• No known significant food interactions affect the absorption of Tetrahydrozoline drops.

Chloramphenicol and Tetrahydrozoline drops should be stored in a cool and dry place, preferably at room temperature, ensuring protection from direct sunlight and moisture. The original container should be tightly sealed to maintain its integrity and prevent contamination. It is crucial not to store the drops in high-temperature areas like bathrooms or near heat sources, as this can compromise their effectiveness. Proper disposal is essential; do not flush or pour them down the drain. Consult a pharmacist or healthcare professional for appropriate disposal methods, and keep the medication away from children to prevent accidental ingestion. Responsible storage and disposal practices ensure the safety and efficacy of these medications.

Following are the quick tips for Chloramphenicol and Tetrahydrozoline Drop:

• Wash your hands thoroughly before and after applying the drops to maintain hygiene.
• Tilt your head back slightly and pull the lower eyelid down to create a pocket.
• Place the prescribed number of drops into this pocket, being careful not to touch the dropper to your eye or any surface.
• Close your eyes gently and apply light pressure to the inner corner of your eye for 1-2 minutes to prevent tear drainage.
• If using more than one type of eye drop, wait at least 5 minutes between applications to prevent washout.
• Do not wear contact lenses while using these drops unless advised by your doctor.
• Store the eye drops at room temperature, away from direct sunlight and moisture.