ISOCORD D 5MG TAB

Isosorbide 5mg tablets primarily work by relaxing and dilating the blood vessels, allowing for improved blood flow. This mechanism of action is attributed to its ability to inhibit phosphodiesterase type 3 (PDE3), an enzyme found in smooth muscle cells. By inhibiting PDE3, isosorbide enhances the levels of cyclic adenosine monophosphate (cAMP), which, in turn, leads to the relaxation of vascular smooth muscles. This relaxation reduces vascular resistance, lowers blood pressure, and decreases the workload on the heart, making it particularly useful in managing angina and certain cardiovascular conditions.

Isosorbide 5mg

Nitrate vasodilator.

Tablet

The following are the uses of Isosorbide 5mg Tablet:

• Used for treating angina, a type of chest pain caused by reduced blood flow to the heart.
• Used to prevent and manage symptoms of chronic stable angina.
• Used to improve exercise tolerance in people with angina.
• Used to reduce the frequency and severity of angina attacks.
• Used as a long-term treatment to control chest pain and improve heart health.
• Used to dilate blood vessels, allowing better blood flow to the heart.
• Used as an alternative for patients who cannot tolerate other angina medications.
• Used in combination with other medications for comprehensive angina management.

In the case of an overdose of Isosorbide 5mg Tablets, it is important to act swiftly. Symptoms may include severe dizziness, fainting, and a rapid or irregular heartbeat. If you or someone else has taken an excessive amount, seek medical assistance immediately. Quick action can help prevent serious health risks associated with an overdose, so do not delay in contacting a healthcare professional or going to the nearest emergency room. Prompt treatment is vital for managing the potential consequences effectively.

In the case of a missed dose of Isosorbide 5mg Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you frequently miss doses, consider setting reminders or using a pill organizer to help you stay on track with your medication regimen. Consult your healthcare provider if you have any concerns or questions regarding missed doses.

To take Isosorbide 5mg Tablet, swallow the tablet whole with a glass of water, preferably at the same time each day, following the exact dosage instructions provided by your healthcare professional.

Here are the conditions and situations when Isosorbide 5mg Tablet should not be taken:

• Should not be used in patients with known allergy or hypersensitivity to Isosorbide or other nitrates.
• Contraindicated in patients with severe anemia, as it may worsen oxygen supply to tissues.
• Not recommended for individuals with narrow-angle glaucoma.
• Avoid using in patients with recent head injury or increased intracranial pressure.
• Should not be used in patients with hypotension (low blood pressure).
• Contraindicated during acute myocardial infarction (heart attack) with right ventricular infarction or low filling pressure.
• Not suitable for individuals with cardiac tamponade (fluid around the heart).
• Should not be used in patients with constrictive pericarditis (inflammation of the heart membrane).
• Avoid in patients with obstructive cardiomyopathy (heart muscle disease).
• Contraindicated in patients with aortic stenosis (narrowing of the aortic valve).
• Not recommended for individuals with obstructive jaundice or increased intracranial pressure.

The side effects of Isosorbide 5mg Tablet may include:

• Headache
• Dizziness
• Nausea and vomiting
• Fatigue or weakness
• Blurred vision
• Flushing (warmth or redness of the skin)
• Increased heart rate or palpitations
• Gastrointestinal discomfort

Following are the precautions and warnings for Isosorbide 5mg Tablet:

• Individuals with a known allergy to Isosorbide or any nitrate-based medications should not take this tablet.
• It is crucial to monitor blood pressure regularly during treatment, especially in patients with existing low blood pressure, as Isosorbide can cause a significant drop in blood pressure.
• Patients with heart conditions, particularly those with aortic stenosis or hypertrophic cardiomyopathy, should exercise caution as Isosorbide may exacerbate these conditions.
• Isosorbide can cause dizziness and lightheadedness, so activities requiring alertness, such as driving or operating heavy machinery, should be avoided until the individual's response to the medication is known.
• Alcohol consumption should be avoided or limited as it may increase the risk of side effects and dizziness.
• Patients with kidney or liver disease should use this medication with caution, as dosage adjustments may be necessary.
• Do not abruptly stop taking Isosorbide without consulting a healthcare professional, as it may lead to withdrawal symptoms and a rebound effect.
• Elderly patients may be more sensitive to the effects of Isosorbide, requiring careful monitoring during treatment.

Following are the drug interactions for Isosorbide 5mg Tablet:

• Antihypertensives, Concurrent use with other antihypertensive medications may cause excessive blood pressure reduction.
• Nitrates, Combined use with other nitrate medications can result in severe hypotension.
• Beta-blockers, May reduce the effectiveness of beta-blockers, requiring close monitoring.
• Sympathomimetic Agents, Isosorbide may counteract the effects of sympathomimetic drugs.
• Alcohol, Consumption of alcohol can increase the risk of hypotension.
• Calcium Channel Blockers, Enhanced hypotensive effects when taken together.
• Tricyclic Antidepressants, Potential for increased hypotensive effects and orthostatic hypotension.

Following are the food interactions to consider with Isosorbide 5mg Tablet:

• Avoid consuming large amounts of grapefruits or grapefruit juice as they can interfere with the metabolism of Isosorbide, leading to increased drug levels in the body.
• Alcohol consumption should be limited or avoided as it may cause excessive dizziness and low blood pressure.
• Avoid high-sodium foods as Isosorbide is used to treat heart conditions, and a low-sodium diet is often recommended for heart health.
• Potassium-rich foods like bananas, oranges, and spinach should be consumed moderately as Isosorbide can lead to potassium retention.
• Caffeine intake should be monitored as it may increase blood pressure and interact with the medication's effects.
• Avoid fatty meals as they can affect the absorption of Isosorbide, potentially reducing its effectiveness.
• Always stay well-hydrated to maintain blood volume and promote better circulation.
• Consult your healthcare provider for a personalized diet plan, especially if you have cardiovascular issues.

Isosorbide 5mg Tablets should be stored in a cool and dry environment, preferably at room temperature, ensuring protection from direct sunlight and moisture. It is crucial to keep the tablets in their original packaging, tightly sealed, to maintain their integrity and prevent contamination. Avoid exposing the medication to heat or cold extremes, as this can impact its effectiveness. When disposing of unused or expired tablets, do not flush them or throw them into the trash; instead, follow local guidelines for pharmaceutical waste disposal or consult a pharmacist for safe disposal options. Always keep medications securely stored away from children to prevent accidental ingestion. Proper storage and disposal practices are essential to ensure the safety and efficacy of Isosorbide 5mg Tablets.

Following are the quick tips for Isosorbide 5mg Tablet:

• Take the tablet as directed by your doctor, typically 3-4 times a day.
• Do not crush or chew the tablet; swallow it whole with a glass of water.
• Maintain a consistent schedule for taking the medication.
• Avoid grapefruit juice and alcohol as they may interact with the medicine.
• If you experience dizziness, rise slowly from a sitting or lying position.
• Inform your doctor about all medications you are taking to prevent interactions.
• Store the tablets in a cool, dry place, away from direct sunlight.
• Do not share this medication with others, even with similar symptoms.