Isoday SR (40mg) 100 Capsules

Glyceryl Trinitrate, also known as nitroglycerin, primarily exerts its therapeutic effects through the release of nitric oxide (NO) after entering the body. Once absorbed, it undergoes metabolic processes, leading to the generation of NO. Nitric oxide is a potent vasodilator, meaning it relaxes and widens blood vessels by acting on the smooth muscle cells within the vascular walls. This relaxation occurs through the activation of soluble guanylyl cyclase, which, in turn, increases the intracellular levels of cyclic guanosine monophosphate (cGMP). Elevated cGMP levels result in the dephosphorylation of myosin light chains, causing smooth muscle relaxation and subsequent vasodilation. The dilation of blood vessels leads to improved blood flow, reduced vascular resistance, and decreased blood pressure, which are the key mechanisms behind the drug's clinical applications.

Glyceryl Trinitrate 40mg

vasodilator

Capsule

The following are the uses of Glyceryl Trinitrate 40mg Capsule:

• Used for managing and preventing chest pain caused by angina.
• Used to rapidly dilate blood vessels, especially during hypertensive emergencies.
• Used to treat heart failure by reducing the workload on the heart.
• Used for pre-operative and post-operative blood pressure management.
• Used to prevent and treat blood clots, particularly in coronary arteries.
• Used to manage acute myocardial infarction, improving blood flow to the heart.
• Used for treating and preventing vascular headaches and migraines.
• Used in emergency settings to manage severe blood pressure spikes.

In the case of an overdose of Glyceryl Trinitrate 40mg Capsules, individuals may experience severe symptoms such as a sudden drop in blood pressure, rapid and weak pulse, dizziness, and fainting. It is crucial to seek medical assistance promptly by contacting emergency services or poison control. They can provide specific guidance based on the patient's condition, including potential treatments like administering oxygen or monitoring vital signs to manage the adverse effects of the overdose.

In the case of a missed dose of Glyceryl Trinitrate 40mg Capsule, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for guidance, as they may recommend adjusting your dosage or provide specific instructions to ensure you receive the correct amount of medication.

To use Glyceryl Trinitrate 40mg Capsule, place the capsule under your tongue, allowing it to dissolve completely without chewing or swallowing, following the prescription instructions for the frequency and duration of administration.

Here are the conditions or situations when Glyceryl Trinitrate 40mg Capsule should not be used:

• Should not be taken by individuals with a known allergy to glyceryl trinitrate or nitrates.
• Contraindicated in patients with severe anemia or recent head injury.
• Not suitable for individuals with increased intracranial pressure or cerebral hemorrhage.
• Should not be used in patients with pericardial tamponade or constrictive pericarditis.
• Contraindicated in individuals with severe aortic stenosis or hypertrophic obstructive cardiomyopathy.
• Avoid using in patients with acute myocardial infarction with low blood pressure.
• Not recommended for patients with extreme hypotension (very low blood pressure).
• Should not be used in patients with closed-angle glaucoma.

The side effects of Glyceryl Trinitrate 40mg Capsule may include:

• Severe headache or migraine
• Dizziness or lightheadedness
• Flushing or redness of the skin
• Palpitations or increased heart rate
• Nausea and vomiting
• Low blood pressure (hypotension)
• Skin rashes or itching
• Dry mouth

Following are the precautions and warnings for Glyceryl Trinitrate 40mg Capsule:

• Not recommended for individuals with an allergy to glyceryl trinitrate or any other nitrates.
• Patients with severe anemia, recent head injury, or increased intracranial pressure should use with caution.
• May cause dizziness or lightheadedness, so caution is advised when performing activities that require alertness.
• Alcohol consumption should be avoided as it can increase the risk of side effects.
• Not suitable for patients with severe heart disease, such as hypertrophic cardiomyopathy or aortic stenosis.
• Should be used with caution in patients with low blood pressure, as it may cause a further drop in blood pressure.
• Discontinue use and seek medical attention if chest pain worsens or lasts longer than the usual duration.
• Keep out of reach of children and store in a cool, dry place.

Following are the drug interactions for Glyceryl Trinitrate 40mg Capsule:

• It can interact with phosphodiesterase inhibitors like sildenafil, tadalafil, and vardenafil, leading to a significant drop in blood pressure.
• Antihypertensive medications such as beta-blockers, ACE inhibitors, and calcium channel blockers may have an additive effect, causing excessive blood pressure reduction.
• The hypotensive effects may be enhanced when used with diuretics, potentially leading to severe hypotension.
• Glyceryl Trinitrate may interact with other nitrates or nitric oxide donors, increasing the risk of hypotension and headaches.
• Alcohol consumption can intensify the vasodilatory effects, resulting in dizziness and lightheadedness.
• Medications metabolized by the liver, such as certain antifungals and antibiotics, might affect Glyceryl Trinitrate's metabolism, altering its effectiveness.
• Caution is advised when combining with erythromycin, as it may increase the risk of hypotension and arrhythmias.

Following are the food interactions for Glyceryl Trinitrate 40mg Capsule:

• Grapefruit juice should be avoided as it can increase the blood levels of Glyceryl Trinitrate, leading to a potential increase in side effects.
• Alcohol consumption may cause a sudden drop in blood pressure, especially when combined with this medication, resulting in dizziness or lightheadedness.
• High-fat meals may delay the absorption of the drug, affecting its effectiveness.
• Caffeine intake may increase the risk of headaches and heart palpitations when used with this medication.
• Dairy products, particularly milk, can interfere with the absorption of Glyceryl Trinitrate, reducing its effectiveness.
• Avoid high-sodium foods as they can counteract the medication's effect on blood pressure.
• Consuming large amounts of garlic might increase the risk of bleeding when used with this medication.
• Vitamin C supplements may interact, potentially reducing the drug's effectiveness.

Glyceryl Trinitrate 40mg Capsules should be stored in a cool, dry area, specifically at room temperature, and protected from light and moisture. The original container should be tightly sealed to maintain its integrity and prevent contamination. It is crucial not to expose the capsules to temperature extremes, so avoid storage in hot places like near stoves or inside cars during summer, as well as freezing environments. Always adhere to the expiration date, and for proper disposal, do not flush or pour the medication down the drain; instead, consult a pharmacist or local waste management guidelines for safe disposal methods. Keep the capsules out of children's reach to prevent accidental consumption.

Following are the quick tips for Glyceryl Trinitrate 40mg Capsule:

• Store the capsules in a cool, dry place, away from direct sunlight.
• Ensure you know how to use the capsule correctly, usually placed under the tongue.
• Keep the capsules in their original packaging to protect them from moisture.
• Always check the expiry date before using the medication.
• Do not crush or chew the capsule; let it dissolve for maximum effectiveness.
• Consult your doctor if you experience severe or persistent headaches while using the medication.
• Inform your healthcare provider about all the medications you are taking to avoid potential interactions.