ISOTIME 60 SR CAP

Isosorbide is a vasodilator that primarily works by relaxing and widening the blood vessels, especially the veins. Its mechanism of action involves stimulating the production of cyclic adenosine monophosphate (cAMP) in vascular smooth muscle cells. This increase in cAMP leads to the activation of protein kinase A, which in turn phosphorylates various proteins involved in smooth muscle contraction. As a result, isosorbide inhibits calcium influx into the cells, causing a reduction in intracellular calcium levels. This relaxation of smooth muscle cells in the blood vessel walls leads to vasodilation, which improves blood flow and reduces the workload on the heart, ultimately lowering blood pressure.

Isosorbide 60mg

Nitrate vasodilator

Capsule

The following are the uses of Isosorbide 60mg Capsule:

• Used for treating heart pain or angina
• Used to prevent or reduce the intensity of chest pain caused by coronary artery disease
• Used to lower blood pressure and reduce the risk of cardiovascular events
• Used to manage symptoms in patients with chronic stable angina
• Used to improve blood flow and oxygen supply to the heart
• Used as a long-term treatment to maintain heart health
• Used for patients who cannot tolerate other anti-anginal medications
• Used to reduce the frequency and severity of angina attacks

In the case of an overdose of Isosorbide 60mg capsules, it is important to remain calm and take immediate action. Call emergency services or seek medical assistance right away. Inform the medical team about the specific medication and dosage taken. They will provide guidance on the necessary steps, which may include inducing vomiting or administering activated charcoal to prevent further absorption. Quick response and professional care are essential in managing the situation effectively.

In the case of a missed dose of Isosorbide 60mg Capsule, it is recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for advice, as they may recommend adjusting your dosage or provide specific instructions to ensure you receive the correct amount of medication.

To take Isosorbide 60mg Capsule, swallow the capsule whole with a full glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare professional.

Here are the conditions or situations when Isosorbide 60mg Capsule should not be used:

• Must not be taken by individuals with a known allergy to Isosorbide or other nitrates.
• Not suitable for individuals with severe anemia.
• Contraindicated in patients with head trauma or increased intracranial pressure.
• Should not be used in patients with recent heart attack or acute myocardial infarction.
• Avoid using if you have a condition called hypertrophic obstructive cardiomyopathy.
• Not recommended for individuals with hypotension (low blood pressure).
• Must not be taken during acute hypotensive conditions, such as during shock or collapse.

The side effects of Isosorbide 60mg Capsule may include:

• Headache
• Dizziness
• Nausea and vomiting
• Weakness or fatigue
• Flushing (feeling of warmth or redness in the face)
• Increased heart rate
• Blurred vision
• Skin rash or itching

Following are the precautions and warnings for Isosorbide 60mg Capsule:

• Do not use if you are allergic to isosorbide or any other nitrates. Discontinue use and seek medical attention if you experience symptoms of an allergic reaction.
• Patients with a history of hypotension (low blood pressure) should use with caution as it may cause a sudden drop in blood pressure.
• It can cause dizziness and lightheadedness, so avoid activities that require alertness, such as driving or operating heavy machinery.
• Alcohol consumption should be avoided as it may increase the risk of side effects.
• Isosorbide capsules should be used with caution in patients with liver or kidney disease, as the dosage may need adjustment.
• Inform your doctor if you have a history of heart disease, anemia, or glaucoma before starting this medication.
• This medication is not recommended for use during pregnancy or breastfeeding unless the potential benefits outweigh the risks.
• Keep this medication out of reach of children and pets, and store it in a cool, dry place.

Following are the drug interactions for Isosorbide 60mg Capsule:

• Concurrent use with nitrates or nitrites may lead to an additive effect, increasing the risk of severe hypotension.
• Phosphodiesterase type 5 inhibitors (e.g., sildenafil, tadalafil) should not be used with Isosorbide, as this combination can lead to severe hypotension and cardiovascular collapse.
• Antihypertensive medications (e.g., beta-blockers, ACE inhibitors, diuretics) may enhance the blood pressure-lowering effect of Isosorbide, increasing the risk of hypotension.
• Alcohol consumption can potentiate the hypotensive effect of Isosorbide, increasing the risk of dizziness or fainting.
• CYP3A4 inhibitors (e.g., ketoconazole, ritonavir) may increase the plasma concentration of Isosorbide, leading to an increased risk of side effects.
• CYP3A4 inducers (e.g., rifampin, carbamazepine) may decrease the effectiveness of Isosorbide by lowering its plasma concentration.
• Heparin or other anticoagulants may increase the risk of bleeding when used with Isosorbide.
• Tricyclic antidepressants (e.g., amitriptyline) or anticholinergics (e.g., atropine) may increase the risk of dry mouth, urinary retention, or other anticholinergic effects when combined with Isosorbide.
• Beta-blockers and calcium channel blockers (e.g., verapamil, diltiazem) may increase the risk of bradycardia and hypotension when used with Isosorbide.

Following are the food interactions for Isosorbide 60mg Capsule:

• Alcohol consumption should be avoided as it can cause excessive blood pressure drop and increase the risk of side effects like dizziness and fainting.
• Grapefruit and grapefruit juice should be consumed with caution as they may increase the levels of Isosorbide in the blood, leading to an increased risk of side effects.
• Avoid caffeine-rich foods and beverages like coffee, tea, and energy drinks, as they can constrict blood vessels and counteract the effects of Isosorbide.
• Limit the intake of high-sodium foods, as sodium can increase blood pressure and reduce the medication's effectiveness.
• Potassium-rich foods like bananas, oranges, and spinach should be consumed in moderation, as excessive potassium can affect heart rhythm.
• Avoid aged cheeses and fermented foods containing tyramine, as they can cause a sudden increase in blood pressure.
• Consume a balanced diet rich in whole grains, fruits, and vegetables to support overall cardiovascular health.
• Always follow the advice of your healthcare provider regarding dietary restrictions and recommendations.

Isosorbide 60mg capsules should be stored in a cool and dry place, preferably at room temperature, ensuring protection from light and moisture. Keep the medication in its original container, tightly sealed, to maintain its integrity. Avoid exposing the capsules to extreme temperatures, such as in the bathroom or near heat sources, as this can impact their effectiveness. Regularly check the expiration date, and dispose of any unused or expired capsules responsibly, refraining from flushing them down the toilet or pouring them into drainage systems. Always consult your pharmacist or healthcare professional for guidance on appropriate disposal methods, and keep the medication securely stored away from children to prevent accidental consumption.

Following are the quick tips for Isosorbide 60mg Capsule:

• Consult your doctor for the correct dosage and prescription, as it varies with age, gender, and medical condition.
• Take the capsule as directed by your doctor, usually 2-3 times a day.
• Swallow the capsule whole with a full glass of water, do not crush or chew.
• Maintain a consistent schedule for taking the medication for best results.
• Avoid missing doses; if you miss one, take it as soon as you remember, but skip if it's almost time for the next dose.
• Do not double the dose to make up for a missed one.
• Store the capsules at room temperature, away from light and moisture.
• Keep all medications out of reach of children and pets.