Isotrate (10mg) 60 Tablets

Isosorbide, a medication found in the Isosorbide 10mg Tablet, acts primarily by relaxing and dilating the blood vessels, leading to improved blood flow. It belongs to the class of drugs known as vasodilators, specifically nitric oxide donors. When administered, isosorbide releases nitric oxide (NO) in the body, which activates the enzyme guanylate cyclase, leading to an increase in cyclic guanosine monophosphate (cGMP) levels. This rise in cGMP causes smooth muscle relaxation in the walls of blood vessels, particularly in the coronary arteries and peripheral circulation. The vasodilation effect of isosorbide helps reduce the workload on the heart, increases oxygen and blood supply to the heart muscle, and improves blood flow to the heart and other organs, thereby treating conditions like angina pectoris and certain circulatory disorders.

Isosorbide 10mg

Nitrate vasodilator.

Tablet

The following are the uses of Isosorbide 10mg Tablet:

• Used for treating chest pain caused by reduced blood flow and oxygen to the heart.
• Used to prevent and manage angina, improving blood flow to the heart.
• Used to lower blood pressure and reduce the risk of cardiovascular events.
• Used in cases of heart failure to improve symptoms and quality of life.
• Used post-heart attack to support recovery and prevent complications.
• Used to reduce the risk of blood clots and related issues in the heart and blood vessels.
• Used for its anti-inflammatory properties to reduce heart-related inflammation.
• Used to manage and stabilize irregular heart rhythms.

To be taken as per doctor's prescription

In the case of an overdose of Isosorbide 10mg Tablets, individuals may experience symptoms such as severe dizziness, fainting, rapid or irregular heartbeat, and chest pain. It is important to recognize that an overdose can lead to a significant drop in blood pressure, causing potential harm. If an overdose is suspected, it is crucial to seek medical assistance promptly. Timely intervention can help manage symptoms and prevent further complications related to the excessive intake of this medication.

In the case of a missed dose of Isosorbide 10mg Tablet, it is recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you frequently miss doses, consider setting reminders or using a pill organizer to help you stay on track with your medication regimen. Consult your healthcare provider if you have any concerns or questions regarding missed doses.

To take Isosorbide 10mg Tablet, swallow the tablet whole with a glass of water, preferably at the same time each day, following the dosage instructions provided by your doctor, typically once or twice daily.

Here are the conditions or situations when Isosorbide 10mg Tablet should not be taken:

• Isosorbide is contraindicated in individuals with a known allergy or hypersensitivity to Isosorbide or other nitrates.
• Not suitable for patients with severe anemia, as it may worsen the condition.
• Should not be used in individuals with severe hypotension (very low blood pressure) or those who have recently had a heart attack.
• Contraindicated in patients with head trauma or increased intracranial pressure.
• Not recommended for patients with narrow-angle glaucoma.
• Avoid using it in individuals with cerebral hemorrhage or recent stroke.
• Isosorbide is not suitable for patients with severe aortic or mitral valve stenosis.
• Should not be used during acute myocardial infarction with severe obstruction of the heart valves.
• Contraindicated in individuals with constrictive pericarditis.
• Avoid using it in patients with cardiac tamponade.

The side effects of Isosorbide 10mg Tablet may include:

• Headache
• Dizziness
• Nausea and vomiting
• Blurred vision
• Weakness or fatigue
• Flushing (feeling of warmth or redness in the face)
• Skin rash or itching

Following are the precautions and warnings for Isosorbide 10mg Tablet:

• Do not take this medication if you are allergic to Isosorbide or any other nitrates. Severe allergic reactions may occur.
• This medication is not recommended for individuals with certain medical conditions like severe anemia, increased intracranial pressure, or recent myocardial infarction.
• Exercise caution if you have a history of hypotension or are taking antihypertensive medications, as Isosorbide can cause a significant drop in blood pressure.
• Patients with glaucoma should use with caution as it may worsen the condition.
• Elderly patients may be more sensitive to the effects of Isosorbide, so dosage adjustments might be necessary.
• Avoid alcohol consumption while taking this medication as it can increase the risk of side effects.
• Isosorbide may cause dizziness or lightheadedness; avoid activities requiring mental alertness until you know how it affects you.

Following are the drug interactions for Isosorbide 10mg Tablet:

• Concurrent use with other nitrates, such as nitroglycerin, can result in additive vasodilatory effects and potentially lead to hypotension.
• Taking Isosorbide with phosphodiesterase type 5 (PDE5) inhibitors like sildenafil, tadalafil, or vardenafil can significantly lower blood pressure, causing dizziness or fainting.
• It may interact with calcium channel blockers (e.g., amlodipine, diltiazem), leading to increased hypotensive effects and potential cardiovascular risks.
• The combination with alpha-blockers (e.g., prazosin, doxazosin) can result in a sudden drop in blood pressure.
• Antihypertensive medications, including beta-blockers and ACE inhibitors, may have additive effects on blood pressure when used with Isosorbide.
• Isosorbide can potentiate the effects of diuretics, increasing the risk of dehydration and electrolyte imbalances.
• Alcohol consumption can intensify the hypotensive effects of Isosorbide, leading to dizziness and impaired motor skills.

Following are the food interactions for Isosorbide 10mg Tablet:

• Alcohol consumption should be avoided as it may increase the risk of side effects and lower blood pressure.
• Grapefruit and grapefruit juice should be consumed with caution as they can increase the levels of Isosorbide in the blood, leading to an increased risk of side effects.
• Avoid high-sodium foods, as they can reduce the effectiveness of Isosorbide in controlling blood pressure.
• Limit the intake of foods containing tyramine, such as aged cheeses, cured meats, and certain types of beer, as they may interact with Isosorbide and cause a sudden increase in blood pressure.
• Avoid or limit the consumption of potassium-rich foods like bananas, oranges, and leafy greens if you are taking Isosorbide with other medications that can increase potassium levels.
• Caffeine intake should be monitored as it may increase blood pressure and reduce the effectiveness of Isosorbide.
• Maintain a consistent and balanced diet, as sudden changes in eating patterns may affect blood pressure and interact with Isosorbide's action.
• Always follow dietary recommendations provided by your healthcare professional, especially if you have dietary restrictions or specific health conditions.

Isosorbide 10mg Tablets should be stored in a cool, dry area, ideally at room temperature, ensuring protection from light and moisture. Keep the tablets in their original container, tightly sealed, to maintain their integrity and prevent contamination. Avoid exposing the medication to extreme temperatures by not storing it in bathrooms or near heat sources. Regularly check the expiration date, and if the tablets are no longer needed or have expired, proper disposal is crucial. Do not dispose of them via household waste or drainage systems; instead, consult your pharmacist or local waste management guidelines for safe disposal practices. Always keep medications secure and out of children's reach to prevent accidental consumption.

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Following are the quick tips for Isosorbide 10mg Tablet:

• Take the tablet as directed by your doctor, typically 2-3 times a day.
• Swallow the tablet whole with a full glass of water, do not crush or chew.
• Maintain a consistent schedule for taking the medication.
• Avoid missing doses, but if you do, take it as soon as you remember.
• Inform your doctor if you have a history of liver or kidney problems.
• Be cautious if you experience dizziness, lightheadedness, or fainting.
• Store the tablets in a cool, dry place, away from direct sunlight.