Isotrate (40mg) 20 Tablets

Isosorbide, the active ingredient in the 40mg tablet, primarily exerts its therapeutic effect through vasodilation. It belongs to the class of drugs known as vasodilators, specifically nitrate vasodilators. The mechanism of action involves the release of nitric oxide (NO) in the body, which then activates soluble guanylate cyclase, leading to an increase in cyclic guanosine monophosphate (cGMP) levels. This cGMP-mediated pathway causes smooth muscle relaxation in blood vessels, particularly in the veins and coronary arteries. By promoting vasodilation, isosorbide reduces vascular resistance, decreases preload, and reduces myocardial oxygen demand, ultimately resulting in improved blood flow to the heart and a reduction in chest pain associated with angina.

Isosorbide 40mg

Nitrate vasodilator.

Tablet

The following are the uses of Isosorbide 40mg Tablet:

• Used for treating chest pain due to reduced blood flow to the heart, a condition known as angina.
• Used to prevent episodes of chest pain and manage symptoms effectively.
• Used for controlling high blood pressure, helping to reduce strain on the heart.
• Used in patients with heart failure to improve heart function and blood flow.
• Used post-heart attack to enhance blood flow and support recovery.
• Used to manage certain heart conditions, like cardiomyopathy, by improving blood circulation.
• Used to treat peripheral vascular disease, enhancing blood flow to the limbs.
• Used to prevent blood clots and improve circulation in specific medical procedures.

To be taken as per doctor's prescription

In the case of an overdose of Isosorbide 40mg Tablets, individuals may experience symptoms such as severe headache, dizziness, and a sudden drop in blood pressure. This can lead to lightheadedness, fainting, and in severe cases, even shock. Prompt medical attention is necessary to manage these symptoms effectively. Treatment may involve monitoring vital signs, providing supportive care, and administering medications to counteract the effects of the overdose. It is crucial to seek professional help to ensure the best possible outcome.

In the case of a missed dose of Isosorbide 40mg Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Never take extra doses to make up for a missed one, as this may lead to an overdose. If you frequently miss doses, consider setting reminders or using a pill organizer to help you stay on track with your medication regimen. Consult your healthcare provider if you have any concerns or questions about managing missed doses.

To take Isosorbide 40mg Tablet, swallow the tablet whole with a glass of water, preferably at the same time each day, following the exact dosage instructions provided by your healthcare professional.

Following are the conditions when Isosorbide 40mg Tablet should not be used:

• Should not be taken by individuals with a known allergy to Isosorbide or other nitrates.
• Not suitable for patients with severe anemia.
• Contraindicated in individuals with recent head injury or increased intracranial pressure.
• Should not be used during acute myocardial infarction (heart attack).
• Not recommended for patients with hypotension (low blood pressure).
• Avoid using if you have a history of stroke or cerebral hemorrhage.
• Do not take if you have a condition called closed-angle glaucoma.
• Contraindicated in patients with severe aortic stenosis (narrowing of the aortic valve in the heart).

The side effects of Isosorbide 40mg Tablet may include:

• Headache
• Dizziness
• Nausea and vomiting
• Weakness or fatigue
• Flushing (feeling of warmth or redness in the face)
• Blurred vision
• Skin rash or itching
• Irregular heartbeat

Following are the precautions and warnings for Isosorbide 40mg Tablet:

• Not recommended for individuals with a known allergy to Isosorbide or any other nitrates.
• Patients with a history of hypotension (low blood pressure) should exercise caution as this medication can cause a sudden drop in blood pressure.
• Those with severe anemia or recent head injury should use with caution and under medical supervision.
• Avoid alcohol consumption while taking this medication as it can increase the risk of dizziness and low blood pressure.
• Patients may experience dizziness, especially when standing up from a sitting or lying position; rising slowly can help alleviate this.
• Isosorbide may cause headaches, which can be relieved with pain relievers; consult your doctor if headaches persist.
• Elderly patients may be more sensitive to the effects, so dosage adjustments might be necessary.
• Always inform your doctor about all medications you are taking to avoid potential drug interactions.

Following are the drug interactions for Isosorbide 40mg Tablet:

• Antihypertensive drugs may have additive effects, leading to excessive blood pressure reduction.
• Beta-blockers can enhance the vasodilatory effects of isosorbide, potentially causing hypotension.
• The hypotensive effects may be increased when used with other vasodilators.
• Nitrates like isosorbide can interact with phosphodiesterase type 5 (PDE5) inhibitors, increasing the risk of hypotension.
• Alcohol consumption can intensify the blood pressure-lowering effects of isosorbide.
• Sympathomimetic agents may counteract the therapeutic effects of isosorbide.
• Calcium channel blockers can have additive effects on blood pressure and heart rate.

Following are the food interactions for Isosorbide 40mg Tablet:

• Avoid grapefruit and grapefruit juice as they can increase the drug's availability, leading to a higher risk of side effects like low blood pressure and headaches.
• Alcohol consumption should be minimized or avoided as it can cause excessive dizziness and lightheadedness.
• Avoid large amounts of salty foods, as high sodium intake can reduce the effectiveness of Isosorbide.
• Limit the intake of foods rich in tyramine, such as aged cheeses, cured meats, and certain types of beer, as they can interact with Isosorbide and lead to a sudden increase in blood pressure.
• Caffeine-rich foods and beverages like coffee, tea, and chocolate may interact with Isosorbide, affecting its effectiveness in controlling blood pressure.
• Avoid energy drinks as they may contain high levels of caffeine and other stimulants, which can interact with Isosorbide and cause irregular heartbeats or increased blood pressure.
• Always read food labels to identify and avoid hidden sources of sodium, tyramine, and caffeine to ensure the medication's effectiveness.
• Maintain a balanced diet as recommended by your healthcare provider, ensuring adequate potassium and magnesium intake for optimal cardiovascular health.

Isosorbide 40mg Tablets should be stored in a secure and dry location, preferably in a medicine cabinet, away from direct sunlight and moisture. Keep the tablets in their original container, tightly sealed, to maintain their integrity and effectiveness. It is crucial to store medications at room temperature, avoiding extreme heat or cold. Regularly check the expiration date on the packaging, and safely dispose of any expired or unused tablets. Do not flush or throw them into the garbage; instead, consult your pharmacist or local waste management guidelines for appropriate disposal methods. Ensure that the medication is kept out of children's reach to prevent accidental consumption, as it is essential for their safety.

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Following are the quick tips for Isosorbide 40mg Tablet:

• Consult your doctor for the right dosage based on your medical condition.
• Take the tablet as directed, usually 3-4 times a day.
• Swallow the tablet whole with a glass of water; do not crush or chew.
• Maintain a consistent schedule for taking the medication.
• Avoid missing doses; take it as soon as you remember if you miss one.
• Do not double the dose to make up for a missed one.
• Inform your doctor if you have any allergies or medical conditions.
• Store the medication at room temperature, away from light and moisture.