Isotrol (0.05%) 10g Cream

Isotretinoin cream works by influencing various processes within the skin cells. It primarily targets the sebaceous glands, which are responsible for producing sebum, an oily substance that can contribute to acne. Isotretinoin binds to specific nuclear receptors in the skin cells, particularly retinoic acid receptors (RARs). This binding activates the receptors, leading to changes in gene expression and cellular activity. The activated RARs regulate the differentiation and proliferation of keratinocytes, which are cells in the outer layer of the skin. This helps normalize the shedding of skin cells and prevents the clogging of hair follicles, reducing the formation of acne lesions. Additionally, isotretinoin inhibits the production of inflammatory mediators, such as cytokines, which play a role in the development of acne. By modulating these cellular processes, isotretinoin cream helps to unclog pores, reduce inflammation, and prevent the formation of new acne lesions.

Isotretinoin

Retinoid.

Cream

The following are the uses of Isotretinoin Cream:

• Used for treating severe acne that has not responded to other treatments.
• Used for reducing skin inflammation and oil production.
• Used for promoting skin cell renewal and unclogging pores.
• Used for preventing scarring and nodular acne formation.
• Used for improving skin texture and reducing acne marks.
• Used for managing acne in combination with other topical treatments.
• Used for long-term acne control and maintenance of clear skin.
• Used for treating acne in patients who are unresponsive to oral medications.

In the case of an overdose of Isotretinoin Cream, it is important to take prompt action. If the cream is ingested, contact a poison control center or seek emergency medical care immediately. Symptoms of an overdose may include nausea, vomiting, and headaches. Do not induce vomiting unless advised by a healthcare professional. Seek medical advice for further guidance on managing the situation effectively.

In the case of a missed dose of Isotretinoin Cream, it is important to apply the medication as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular application schedule. Do not apply extra cream to make up for the missed dose, as this may increase the risk of side effects. If you frequently miss doses, it's best to consult your healthcare provider for advice on how to maintain a consistent treatment routine. They can provide guidance on what to do in such situations and ensure you're using the medication effectively.

To apply Isotretinoin Cream, wash and dry your hands and affected skin area, then gently apply a thin layer of the cream to the skin, avoiding contact with eyes and mouth, and wash your hands after application, typically once or twice daily, or as directed by your healthcare provider.

Following are the conditions or situations when Isotretinoin Cream should not be used:

• Should not be used in individuals with a known allergy or hypersensitivity to Isotretinoin or any of its components.
• Contraindicated in pregnant women as it can cause severe birth defects.
• Avoid using in breastfeeding women due to potential risks to the infant.
• Not recommended for individuals with severe liver or kidney disease.
• Should not be used to treat skin conditions around the eyes, mouth, or mucous membranes.
• Avoid using on sunburned, windburned, dry, chapped, irritated, or broken skin.
• Do not use if you are currently taking other medications that may interact with Isotretinoin.
• Contraindicated in individuals with a history of severe depression or psychiatric disorders.
• Not suitable for those with a history of severe inflammatory bowel disease.
• Should not be used to treat skin conditions that have not been evaluated by a doctor.

The side effects of Isotretinoin Cream may include:

• Skin irritation, redness, or itching at the application site
• Dryness or peeling of the skin
• Increased sensitivity to sunlight
• Changes in skin color (lightening or darkening)
• Nosebleeds or dry nose
• Dryness or irritation of the lips
• Temporary worsening of acne (initial flare-up)
• Skin rash or hives

Following are the precautions and warnings:

• Isotretinoin Cream should be used with caution in patients with a history of eczema or other skin conditions, as it may cause skin irritation or worsen existing conditions.
• Avoid contact with eyes, nose, mouth, and other mucous membranes when applying the cream. In case of accidental contact, rinse thoroughly with water.
• Sun sensitivity may increase while using Isotretinoin Cream, so it is advisable to minimize sun exposure and use protective clothing and sunscreen.
• This medication may make your skin more fragile; avoid aggressive skincare procedures like waxing, laser treatments, or aggressive scrubbing.
• Do not use Isotretinoin Cream on broken or infected skin, and avoid using it on skin conditions it is not prescribed for.
• Pregnant individuals should not use Isotretinoin Cream, as it can cause severe birth defects. Effective contraception is essential during treatment.
• Breastfeeding while using Isotretinoin Cream is not recommended due to the potential risks to the infant.
• Inform your healthcare provider if you have a history of depression or psychiatric disorders before starting Isotretinoin Cream.

Following are the drug interactions for Isotretinoin Cream:

• Avoid combining with other topical retinoids or medications that cause photosensitivity, as this may increase skin irritation.
• Isotretinoin may reduce the effectiveness of contraceptive creams and sponges.
• Topical antibiotics like erythromycin or clindamycin can be affected by Isotretinoin, potentially reducing their antibacterial activity.
• The absorption of other topical medications might be enhanced, increasing the risk of systemic side effects.
• Oral vitamin A supplements should be used cautiously as Isotretinoin is a vitamin A derivative, and excessive vitamin A levels can be toxic.
• Skin peeling agents like benzoyl peroxide or salicylic acid may cause excessive dryness and irritation when used with Isotretinoin.
• Certain herbal supplements (e.g., St. John's Wort) may decrease the effectiveness of Isotretinoin.

Following are the food interactions to consider with Isotretinoin Cream:

• Avoid consuming foods high in vitamin A or beta-carotene, such as liver, sweet potatoes, carrots, and leafy green vegetables, as Isotretinoin can increase vitamin A levels in the body, leading to potential toxicity.
• Grapefruit and grapefruit juice should be consumed with caution as they can alter the metabolism of Isotretinoin, possibly leading to increased side effects.
• Dairy products like milk and cheese may interfere with the absorption of Isotretinoin, so it's advisable to separate them by a few hours.
• Fatty or greasy foods might not directly interact with Isotretinoin Cream, but they can exacerbate acne, which the medication is often used to treat.
• Alcohol doesn't directly interact with Isotretinoin Cream, but it can contribute to dehydration and skin irritation, potentially worsening skin conditions.
• Certain spices and hot foods might cause skin flushing or irritation when using Isotretinoin, so it's best to moderate their consumption.
• Always follow your healthcare provider's advice on dietary restrictions or recommendations while using Isotretinoin Cream for optimal results.

Isotretinoin Cream should be stored in a secure and controlled environment, preferably in a locked cabinet or a designated medication storage area. The storage location should be cool, dry, and free from excessive heat, direct sunlight, and moisture to maintain the integrity of the medication. It is crucial to keep the cream in its original packaging, ensuring the container remains tightly sealed to prevent contamination and maintain its effectiveness. When disposing of Isotretinoin Cream, do not flush it down the toilet or dispose of it through the sink or drain. Instead, follow local guidelines for pharmaceutical waste disposal or consult a pharmacist or healthcare professional for appropriate methods to ensure environmental safety. Always exercise caution to keep medications away from children and pets to prevent accidental exposure or ingestion.

Following are the quick tips for Isotretinoin Cream:

• Wash your hands before and after applying the cream to maintain hygiene.
• Clean and dry the affected area before applying the cream for better absorption.
• Use a thin layer of the cream and gently rub it into the skin until it is evenly absorbed.
• Avoid applying the cream to broken or irritated skin to prevent further irritation.
• Do not apply the cream near the eyes, mouth, or open wounds.
• Protect treated areas from sunlight and avoid sun exposure as much as possible.
• Inform your doctor if you experience any skin reactions or if symptoms persist.