Itaglip Plus (50/500mg) 14 Tablets

Sitagliptin, a DPP-4 inhibitor, enhances the activities of GLP-1 and GIP, which leads to improved glycemic control in patients with type 2 diabetes. It achieves this by reducing fasting and post-prandial blood glucose levels. On the other hand, Metformin, a guanidine derivative, possesses antimicrobial properties. It reduces glucose production by the liver, increases glucose uptake by skeletal muscle, and enhances glucose uptake and utilization by anaerobic pathways in tissues such as the kidney. Additionally, it diminishes hunger and induces weight loss in some individuals. The combination of Sitagliptin 50mg and Metformin 500mg is typically prescribed to adults with type 2 diabetes when diet and exercise alone are not sufficient to manage blood sugar levels. It's worth noting that this description is a simplified overview, and the actual mechanisms of action for these drugs are more intricate and are still being researched.

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Metformin, Sitagliptin

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Biguanide, DPP-4 Inhibitor

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Tablet

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Unveiling its multifaceted uses and transformative applications as follows:

• Treatment of type 2 diabetes mellitus
• Enhances the actions of incretin hormones glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP)
• Delays the absorption of glucose in the blood stream
• Ensures gradual release of glucose and stimulates the pancreas to produce insulin
• Metformin acts by reducing the excessive secretion of glucose from the liver
• Downregulates glucose absorption in the gastrointestinal tract
• Increases the uptake of glucose by skeletal muscle
• Reduced chances of diabetic complications like neuropathy, retinopathy, and nephropathy

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Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• For treating type 2 diabetes, the recommended dose of Sitagliptin is 50mg to be taken once a day.
• The recommended dose of Metformin ranges from 500mg to 2000mg depending on the severity of the patient's insulin resistance and their response to the medication.
• It is crucial to adhere to the prescription provided to you by your doctor.
• Please consult your doctor for any specific dosage instructions pertaining to your individualized health needs and medical history.

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An overdose of sitagliptin and metformin may result in low blood sugar, nausea, vomiting, dizziness, and headaches. It is vital to seek immediate medical attention in order to prevent any potential health complications. In order to treat overdose symptoms, doctors primarily focus on supporting the patient's vital signs, managing extreme symptoms, and reversing the effects of the overdose over time. This may include administering medications such as glucose or glucagon to stabilize blood sugar levels. If necessary, they may also provide treatment for nausea and vomiting. It is crucial that the patient is closely monitored by medical staff, who will pay careful attention to vital signs, glucose levels, and overall physiological state in order to ensure a full recovery from the overdose. They may also provide additional advice and guidance for managing and preventing future overdose incidents.

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It is important to consult with your doctor if you missed a dose of your medication. Your doctor will advise you on how to proceed based on your specific medication and health condition. In the case of medications like sitagliptin and metformin, if you missed a dose, it is recommended to take it as soon as possible. If it is close to your next scheduled dose, you can continue with your regular schedule and skip the missed dose to avoid taking a double dose. It is essential to avoid stopping or changing your medication regimen without discussing it with your doctor, as this can lead to complications. To ensure you make the right decision, always consult with your medical professional for specific guidance on managing missed doses. They will provide you with important safety information and advice tailored to your circumstances, helping you make the best possible decision.

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The combination of sitagliptin and metformin should be taken orally as prescribed by a healthcare provider, typically once or twice daily with meals to reduce gastrointestinal side effects. The dose is based on the patient's current condition, renal function, and prior response to therapy. 

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Discerning instances where this medication may not be appropriate:

• Hypersensitivity
• Kidney problems
• Ongoing ketoacidosis
• Surgical anesthesia
• Certain drugs

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Unraveling the side effects lurking behind this medications are as follows:

• Increased risk of hypoglycemia (low blood sugar)
• Weight loss
• Fatigue
• Muscle pain

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Here are the crucial warnings and precautions for this medication:

• Patients with congestive heart failure (CHF) and those exposed to stress, such as infection, fever, trauma, or surgery, should use this medication with caution.
• It is not intended for the treatment of diabetic ketoacidosis or type 1 diabetes mellitus.
• Renal impairment, particularly with a glomerular filtration rate (GFR) between 30-45 mL/min, requires careful monitoring.
• The safety of this medication during pregnancy has not been well established; it should be used only if recommended by a healthcare provider.

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Drug interactions with metformin and sitagliptin include:

• Insulin and other antidiabetic agents (e.g., sulfonylureas) (may increase risk of hypoglycemia)
• Renal impairment (may require dose adjustments)
• CYP3A4 inhibitors (e.g., ketoconazole) (may increase sitagliptin levels)
• CYP3A4 inducers (e.g., rifampin) (may decrease sitagliptin levels)
• Diuretics (e.g., furosemide) (may increase risk of dehydration and affect blood glucose control)
• NSAIDs (e.g., ibuprofen) (may increase risk of renal impairment)
• Alcohol (may enhance effects on blood glucose levels and increase risk of dehydration)

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When storing Sitagliptin and Metformin tablets, ensure they are kept in an airtight container in a cool, dry place, away from heat and direct light. These medications should be kept out of reach of children and pets. It is important to follow the instructions on the medication label and consult a healthcare professional if you have any questions. Optimal storage methods may vary, so it is always best to consult the specific product's instructions and a healthcare professional if you have any questions. In addition, it is important to note that Metformin should be kept in an airtight container to avoid exposure to moisture, which may affect its efficacy and safety. It is also important to discard any expired or unused medication according to the instructions of a knowledgeable professional or pharmacist.

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