Jezeta (10/40mg) 10 Tablets

The combination of Ezetimibe 10mg and Atorvastatin 40mg in a single tablet has a synergistic effect on lowering cholesterol levels. Ezetimibe works by inhibiting the absorption of cholesterol in the small intestine, primarily by targeting the Niemann-Pick C1-Like 1 (NPC1L1) protein, which is responsible for cholesterol uptake. This reduces the amount of cholesterol entering the bloodstream. Atorvastatin, on the other hand, belongs to the statin class of drugs and acts by competitively inhibiting HMG-CoA reductase, a key enzyme in cholesterol synthesis in the liver. This inhibition leads to a decrease in the production of cholesterol, particularly low-density lipoprotein (LDL) cholesterol. Together, Ezetimibe and Atorvastatin effectively reduce cholesterol levels by targeting both cholesterol absorption and synthesis pathways, making them a powerful combination for managing dyslipidemia and cardiovascular risk.

Ezetimibe 10mg, Atorvastatin 40mg

Statin and cholesterol absorption inhibitor.

Tablet

The following are the uses of Ezetimibe 10mg, Atorvastatin 40mg Tablet:

• Used for lowering high cholesterol and triglyceride levels in the blood.
• Used to reduce the risk of heart disease and stroke in patients with elevated lipid levels.
• Used to slow down the formation of fatty deposits in blood vessels, aiding in the prevention of atherosclerosis.
• Used for managing cholesterol levels in patients with a poor response to statin therapy alone.
• Used to enhance the effectiveness of statin therapy in lowering LDL cholesterol.
• Used for improving overall lipid profile, including reducing total cholesterol and LDL cholesterol.
• Used in patients with a history of coronary heart disease or those at high risk of cardiovascular events.

To be taken as per doctor's prescription

In the case of an overdose of Ezetimibe 10mg and Atorvastatin 40mg tablets, it is important to recognize the potential symptoms. These may include muscle pain, tenderness, or weakness, as well as liver problems and gastrointestinal issues. If an overdose is suspected, seek medical advice promptly. Treatment may involve supportive care and managing symptoms to prevent further complications. It is crucial to take these medications as directed by a healthcare professional to minimize the risk of overdose.

In the case of a missed dose of Ezetimibe 10mg, take it as soon as you remember, but if it's close to your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. For Atorvastatin 40mg, if you miss a dose, take it as soon as you remember, but if it's almost time for your next dose, skip the missed dose and continue with your regular dosing routine. It's important not to double the dose to make up for a missed one, as this may increase the risk of side effects. Consult your healthcare provider if you frequently miss doses or have concerns about managing your medication schedule.

To take the Ezetimibe 10mg, Atorvastatin 40mg Tablet, swallow the tablet whole with a full glass of water once daily, preferably at the same time each day, following the prescription instructions provided by your healthcare professional.

Following are the conditions or situations when Ezetimibe 10mg, Atorvastatin 40mg Tablet should not be taken:

• Should not be taken by individuals who are allergic to Ezetimibe or Atorvastatin or any other similar cholesterol-lowering medications.
• Contraindicated in patients with active liver disease or unexplained elevated liver enzymes.
• Not recommended for individuals with uncontrolled hypothyroidism.
• Should not be used in pregnant or breastfeeding women.
• Avoid using this medication if you have a history of muscle pain or weakness (myopathy).
• Not suitable for individuals with a history of unexplained elevated creatine kinase (CK) levels.
• Contraindicated in patients with homozygous familial hypercholesterolemia.
• Should not be taken if you have or have had severe, chronic or active liver disease.

The side effects of Ezetimibe 10mg, Atorvastatin 40mg Tablet may include:

• Muscle pain and weakness
• Joint pain
• Diarrhea
• Constipation
• Abdominal pain
• Nausea and vomiting
• Increased blood sugar levels
• Liver enzyme abnormalities

Following are the precautions and warnings for Ezetimibe 10mg, Atorvastatin 40mg Tablet:

• Do not start or stop the medication without consulting your doctor, especially if you have a known allergy to Ezetimibe or Atorvastatin or any other inactive ingredients in the tablet.
• Regular monitoring of liver function is necessary while taking this medication, and any signs of liver problems should be reported to the doctor immediately.
• This medication may affect your blood sugar levels, so diabetic patients should monitor their blood glucose regularly.
• Patients with a history of kidney disease should exercise caution and inform their doctor, as dosage adjustments might be required.
• Avoid consuming large quantities of alcohol while on this medication, as it may increase the risk of liver-related side effects.
• Inform your doctor about all the medications you are currently taking to avoid potential drug interactions.
• Pregnant or breastfeeding women should consult their healthcare provider before taking this medication, as its effects during these periods are not well established.

Following are the drug interactions for Ezetimibe 10mg and Atorvastatin 40mg Tablet:

• Cyclosporine and gemfibrozil can increase the risk of muscle-related side effects when taken with this combination.
• Antacids containing aluminum or magnesium may reduce the absorption of ezetimibe, so take them at least 2 hours apart.
• Atorvastatin can have increased blood levels when taken with certain antifungal medications like ketoconazole or HIV protease inhibitors, leading to a higher risk of side effects.
• Grapefruit juice should be avoided as it can increase the levels of atorvastatin, potentially causing muscle toxicity.
• Ezetimibe may affect the absorption of certain medications like digoxin, ciclosporin, and colestyramine, so take them separately.
• The effectiveness of oral contraceptives may be reduced by atorvastatin, so an alternative or additional contraceptive method is recommended.
• Caution is advised with fibrates like fenofibrate, as the combination may increase the risk of muscle problems and rhabdomyolysis.

Following are the food interactions for Ezetimibe 10mg, Atorvastatin 40mg Tablet:

• Grapefruit and grapefruit juice should be avoided as they can increase the levels of Atorvastatin in the blood, leading to potential muscle-related side effects.
• Alcohol consumption should be limited as it can increase the risk of liver-related issues, especially when combined with Atorvastatin.
• High-fat meals may slightly increase Ezetimibe absorption, but it's generally well-tolerated and doesn't require specific dietary restrictions.
• Avoid excessive consumption of foods high in cholesterol and saturated fats, as the medication is intended to manage cholesterol levels.
• Maintain a balanced diet rich in fiber, whole grains, fruits, and vegetables to support cardiovascular health.
• Consider reducing salt intake to help control blood pressure, especially if hypertension is a concern.
• Stay hydrated by drinking an adequate amount of water throughout the day.
• Avoid excessive caffeine intake, as it may interact with the medication's effects on the cardiovascular system.

Ezetimibe 10mg, Atorvastatin 40mg Tablets should be stored in a cool and dry place, preferably at room temperature, ensuring protection from light and moisture. The original container should be tightly sealed to maintain its integrity and prevent contamination. It is crucial not to store the medication in the bathroom or near heat sources as temperature fluctuations can impact its effectiveness. Proper disposal of any unused or expired tablets is essential; avoid flushing or pouring them down the drain. Consult your pharmacist for guidance on safe disposal practices, and always keep medications out of children's reach to prevent accidental consumption.

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Following are the quick tips for Ezetimibe 10mg, Atorvastatin 40mg Tablet:

• Take the tablet as directed by your doctor, typically once daily.
• Swallow the tablet whole; do not crush or chew it.
• Take it at the same time each day to maintain consistent medication levels.
• It can be taken with or without food, but be consistent with your routine.
• Do not increase or decrease the dosage without medical advice.
• Inform your doctor about all medications you are taking to avoid interactions.
• Store the medication in a cool, dry place, away from direct sunlight.