KAMAGRA 100MG "BOX" (SILDENAFIL CITRATE)

Sildenafil, a phosphodiesterase type 5 (PDE5) inhibitor, exerts its mechanism of action by selectively inhibiting the PDE5 enzyme. PDE5 is responsible for the degradation of cyclic guanosine monophosphate (cGMP) in smooth muscle cells. By inhibiting PDE5, sildenafil enhances the effects of nitric oxide, a signaling molecule that relaxes smooth muscles. This inhibition leads to increased levels of cGMP, which promotes smooth muscle relaxation, particularly in the corpus cavernosum of the penis. The resulting vasodilation improves blood flow to the penile region, facilitating and sustaining an erection in response to sexual stimulation. This targeted mechanism makes sildenafil effective in treating erectile dysfunction by addressing the physiological processes involved in achieving and maintaining an erection.

Phosphodiesterase type 5 inhibitor.

Tablet

The following are the uses of Sildenafil Tablet:

• Used for treating Erectile Dysfunction (ED) in men, helping achieve and maintain an erection.
• Used for managing Pulmonary Arterial Hypertension (PAH), reducing blood pressure in the lungs.
• Used for improving exercise capacity in individuals with PAH, enabling better physical activity.
• Used for enhancing sexual performance and satisfaction in men with ED.
• Used for addressing high blood pressure in the lungs caused by various conditions.
• Used for supporting sexual health and overall well-being in certain medical cases.
• Used for increasing blood flow to the lungs and improving oxygen levels.

In the case of an overdose of Sildenafil Tablets, it is important to recognize the signs and symptoms, which may include severe headaches, prolonged and painful erections, vision changes, and dizziness. If an overdose is suspected, seek medical advice promptly. Treatment options for overdose may include supportive care, ensuring the patient's vital signs are stable, and administering specific medications to counteract the effects of the drug. Quick action can help manage the situation effectively.

In the case of a missed dose of Sildenafil Tablet, it is recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed one. It is crucial not to double the dose to make up for a missed one, as this may increase the risk of side effects. If you have missed multiple doses, contact your healthcare provider for guidance on how to safely resume your medication schedule. It is essential to maintain a consistent dosing routine for optimal effectiveness.

To take Sildenafil tablets, swallow the tablet whole with a glass of water, preferably one hour before sexual activity, as directed by your healthcare professional, ensuring you follow the prescribed dosage and timing instructions provided for optimal effectiveness.

Following are the conditions and situations when Sildenafil Tablet should not be used:

• Must not be used in individuals with a known allergy to Sildenafil or related medications.
• Contraindicated in patients with severe cardiovascular conditions, such as unstable angarrhythmia, recent heart attack, or severe low blood pressure.
• Not suitable for individuals who are currently taking nitrates or nitric oxide donors.
• Should not be used in patients with certain eye conditions like non-arteritic anterior ischemic optic neuropathy (NAION).
• Contraindicated in individuals with severe liver impairment.
• Not recommended for patients with severe kidney disease requiring dialysis.
• Must not be used in combination with other erectile dysfunction medications.
• Contraindicated in patients who have had a stroke or life-threatening arrhythmia in the past 6 months.

The side effects of Sildenafil Tablet may include:

• Headache
• Dizziness
• Flushing (feeling warm)
• Nasal congestion or runny nose
• Nausea
• Indigestion
• Changes in color vision (seeing a blue tinge)
• Sensitivity to light
• Prolonged and painful erection (priapism)

Following are the precautions and warnings for Sildenafil Tablet:

• Not recommended for individuals with a known allergy to Sildenafil or similar medications.
• Patients with cardiovascular diseases should use with caution and under medical supervision, as it may affect blood pressure.
• Those with a history of stroke, heart attack, or life-threatening arrhythmia should not use Sildenafil without medical advice.
• May cause visual disturbances; patients experiencing such side effects should avoid driving or operating machinery.
• Alcohol consumption should be avoided as it can increase the risk of side effects and may reduce the effectiveness of Sildenafil.
• Not intended for individuals under 18 years of age.
• Seek immediate medical attention if an erection lasts longer than 4 hours or is painful, to prevent long-term damage.

Following are the drug interactions for Sildenafil Tablet:

• Concurrent use with nitrates (e.g., nitroglycerin) or nitric oxide donors (e.g., amyl nitrite) can cause a significant drop in blood pressure, leading to serious cardiovascular risks.
• Sildenafil should not be taken with other phosphodiesterase type 5 inhibitors (e.g., tadalafil, vardenafil), as it may increase the risk of side effects.
• Caution is advised when combining Sildenafil with alpha-blockers (e.g., doxazosin, tamsulosin) due to the potential for additive blood pressure-lowering effects.
• Sildenafil may interact with certain antifungal medications (e.g., ketoconazole, itraconazole), leading to increased levels of Sildenafil in the blood and increased risk of side effects.
• The combination of Sildenafil and protease inhibitors (e.g., ritonavir, saquinavir) may result in higher concentrations of Sildenafil, increasing the likelihood of side effects.
• Sildenafil may interact with certain medications for hypertension, such as calcium channel blockers, potentially enhancing the blood pressure-lowering effects.
• Combining Sildenafil with certain antibiotics (e.g., erythromycin, clarithromycin) may alter Sildenafil metabolism, leading to higher blood levels.
• Caution is needed when taking Sildenafil with medications that affect the CYP3A4 enzyme (e.g., grapefruit juice, some antihistamines, and certain antidepressants), as they can alter Sildenafil's effectiveness and side effect profile.
• Sildenafil may reduce the effectiveness of some antiviral medications, such as ritonavir, leading to possible complications when taken together.

Following are the food interactions for Sildenafil Tablet:

• Grapefruit and grapefruit juice should be consumed with caution as they can increase the levels of Sildenafil in the blood, potentially leading to increased side effects.
• Avoid high-fat meals as they may decrease the absorption of Sildenafil, affecting its effectiveness.
• Alcohol consumption should be limited as it can lower blood pressure, which may be additive to the blood pressure-lowering effect of Sildenafil, especially in large amounts.
• Caffeine-rich foods and beverages may slightly decrease the absorption of Sildenafil, but this interaction is generally not significant.
• Spicy foods may not directly interact with Sildenafil, but they can contribute to heartburn or acid reflux, which could be problematic for some individuals.
• Avoid consuming large amounts of garlic as it may inhibit platelet aggregation, potentially increasing the risk of bleeding when combined with Sildenafil.
• Avoid excessive consumption of chocolate, as it contains small amounts of caffeine and theobromine, which may interact with Sildenafil and affect its efficacy.
• Always consult your healthcare provider for personalized advice on food interactions based on your medical history.

Sildenafil tablets should be stored in a secure and dry location, away from direct sunlight and moisture. It is crucial to keep the medication in its original container, tightly sealed, to maintain its integrity and prevent exposure to environmental factors. Avoid storing it in bathrooms or kitchens, as temperature fluctuations and humidity can impact its effectiveness. Always be mindful of the expiration date, and dispose of any unused tablets properly, avoiding flushing or pouring them down the drain. Contact your pharmacist or healthcare professional for guidance on appropriate disposal methods to ensure environmental safety. Keep the medication out of children's reach to prevent accidental consumption.

Following are the quick tips for Sildenafil Tablet:

• Take the tablet as directed by your doctor, usually 1 hour before sexual activity.
• Avoid heavy meals and excessive alcohol as they can reduce the effectiveness of the medication.
• Do not crush or chew the tablet; swallow it whole with a glass of water.
• Inform your doctor about all medications you are taking to prevent potential interactions.
• Store the tablets at room temperature, away from moisture and direct sunlight.
• Seek immediate medical attention if you experience sudden vision loss or hearing impairment.
• Do not take more than one dose in a 24-hour period.