KANACILLIN FORTE INJ

Kanamycin, an aminoglycoside antibiotic, disrupts protein synthesis in bacteria by binding to the 30S ribosomal subunit, leading to incorrect reading of tRNA, causing bacterial cell death. Procaine Penicillin, a beta-lactam antibiotic, exerts its bactericidal effect by inhibiting the synthesis of the bacterial cell wall. It specifically targets penicillin-binding proteins (PBPs), which are essential for cross-linking peptidoglycan strands, ultimately weakening the cell wall and causing cell lysis.

Kanamycin (Acid Sulphate) 250000IU, Procaine Penicillin 750

Aminoglycoside and Penicillin.

Injection

The following are the uses of Kanamycin (Acid Sulphate) 250000IU, Procaine Penicillin 750 Injection:

• Used for treating severe bacterial infections such as respiratory tract infections, skin and soft tissue infections, and urinary tract infections.
• Used for controlling bacterial infections in livestock and promoting growth in farm animals.
• Used for the treatment of bacterial infections in plants, particularly in agriculture and horticulture.
• Used for preventing and controlling bacterial infections during surgical procedures.
• Used for managing bacterial infections in open wounds, burns, and ulcers.
• Used for treating bacterial conjunctivitis and other eye infections.
• Used for research and development in microbiology and antibiotic resistance studies.
• Used for the selective isolation and cultivation of certain bacteria in laboratory settings.

In the case of an overdose of Kanamycin (Acid Sulphate) 250000IU, symptoms may include dizziness, hearing loss, and kidney damage. Prompt medical care is necessary to manage these effects. For Procaine Penicillin 750 Injection, an overdose can lead to severe allergic reactions, nausea, and seizures. Medical intervention is required to address these potential consequences and ensure patient safety.

In the case of a missed dose of Kanamycin (Acid Sulphate) 250000IU, administer the missed dose as soon as possible, but skip it if it's almost time for the next dose. Do not double the dose to make up for the missed one. For Procaine Penicillin 750 Injection, if a dose is missed, give it as soon as possible, but if it's almost time for the next dose, skip the missed dose and continue with the regular schedule. It is important to maintain a consistent dosing schedule for both medications.

To administer Kanamycin (Acid Sulphate) 250000IU and Procaine Penicillin 750 Injection, draw the medication into a syringe and inject it intramuscularly, following the prescribed dosage and schedule provided by your healthcare professional.

Following are the conditions/situations when Kanamycin (Acid Sulphate) 250000IU and Procaine Penicillin 750 Injection should not be used:

• Avoid if you have a known allergy or hypersensitivity to Kanamycin, any aminoglycoside antibiotics, or Penicillin.
• Do not use if you have or have ever had hearing loss or kidney disease.
• Not suitable for patients with a history of neuromuscular disorders.
• Should not be used in patients with a history of severe gastrointestinal diseases.
• Contraindicated in individuals with a history of severe or multiple allergies.
• Do not use if you have a history of asthma or other respiratory conditions.
• Not recommended for patients with a history of prolonged or severe diarrhea.
• Avoid if you have a history of neurological disorders or seizure disorders.

The side effects of Kanamycin (Acid Sulphate) 250000IU and Procaine Penicillin 750 Injection may include:

• Nausea and vomiting
• Diarrhea
• Skin rashes or itching
• Joint pain or stiffness
• Hearing loss or ringing in the ears (tinnitus)
• Dizziness or vertigo
• Kidney damage (increased risk with prolonged use)
• Allergic reactions, including hives, swelling, and difficulty breathing

Following are the precautions and warnings for Kanamycin (Acid Sulphate) 250000IU, Procaine Penicillin 750 Injection:

• Allergic reactions may occur, and the injection is contraindicated in patients with known hypersensitivity to kanamycin, penicillin, or other components.
• Use with caution in patients with renal impairment, as both kanamycin and penicillin can cause nephrotoxicity.
• Kanamycin may cause ototoxicity, leading to hearing impairment or balance issues, especially with prolonged use or in high doses. Patients should be monitored for signs of hearing loss.
• May exacerbate neuromuscular blockade in patients receiving muscle relaxants, particularly in those with pre-existing neuromuscular disorders.
• Prolonged use can lead to superinfections, including fungal or antibiotic-resistant bacterial infections. If signs of superinfection occur, discontinue the medication.
• Use with caution in patients with a history of penicillin allergy, as severe reactions, including anaphylaxis, may occur.
• Pregnant or breastfeeding women should consult a healthcare provider before use, as the safety of this combination during pregnancy and lactation is not well-established.
• Use with caution in patients with hepatic dysfunction, as dose adjustments may be necessary.
• Increased risk of ototoxicity when combined with other ototoxic drugs, such as aminoglycosides or loop diuretics.
• Monitor for signs of severe allergic reactions, including skin rash, difficulty breathing, or swelling of the face and throat, and seek immediate medical attention if they occur.
• Safety and efficacy in neonates and young children should be considered before use, as they may be more sensitive to potential adverse effects.

Following are the drug interactions for Kanamycin (Acid Sulphate) 250000IU and Procaine Penicillin 750 Injection:

• Neuromuscular blocking agents and Kanamycin can enhance neuromuscular blockade, potentially leading to respiratory distress.
• Concomitant use of other nephrotoxic drugs with Kanamycin may increase the risk of kidney damage.
• Procaine Penicillin may reduce the effectiveness of oral contraceptives, requiring alternative contraceptive methods.
• Anticoagulants like warfarin can have their effects enhanced by Procaine Penicillin, necessitating close monitoring.
• Methotrexate toxicity may increase when used with Procaine Penicillin, requiring dosage adjustments.
• Procaine Penicillin may reduce the clearance of methotrexate, leading to potential toxicity.
• May interact with live vaccines, affecting their efficacy and safety.

Following are the food interactions for Kanamycin (Acid Sulphate) 250000IU and Procaine Penicillin 750 Injection:

• Avoid consuming alcohol during and after the medication period as it may increase the risk of side effects and slow down the healing process.
• Grapefruit and grapefruit juice should be avoided as they can interfere with the absorption and metabolism of the antibiotics, potentially reducing their effectiveness.
• Dairy products like milk, cheese, and yogurt may decrease the absorption of these antibiotics, so it's best to separate them by a few hours.
• Foods high in calcium, like calcium-fortified juices or supplements, can also interact with these antibiotics and reduce their absorption.
• Vitamin K-rich foods such as spinach, kale, and broccoli may interfere with the action of Procaine Penicillin, as it is an antibiotic that can affect blood clotting.
• Maintain a balanced diet, as Kanamycin can sometimes cause changes in blood sugar levels, especially in diabetic patients.
• Ensure adequate fluid intake to prevent dehydration, as Kanamycin can potentially affect kidney function.
• Avoid high-sodium foods, as they may increase the risk of electrolyte imbalances, especially with prolonged use of Procaine Penicillin.

Kanamycin (Acid Sulphate) 250000IU and Procaine Penicillin 750 Injection should be stored in a controlled environment, preferably at room temperature, away from excessive heat, direct sunlight, and moisture. Keep the medications in their original packaging, tightly sealed, to maintain their integrity and prevent contamination. It is crucial to adhere to the recommended storage conditions to ensure the effectiveness and safety of the medicines. When disposing of any unused or expired portions, avoid flushing or pouring them down the drain. Instead, consult a healthcare professional or pharmacist for appropriate disposal methods to minimize environmental impact. Always keep medications securely stored and out of the reach of children to prevent accidental consumption.

Following are the quick tips for Kanamycin (Acid Sulphate) 250000IU and Procaine Penicillin 750 Injection:

• Consult a doctor for the prescription and dosage instructions.
• Administer the injection as directed by the healthcare professional.
• Ensure the injection is given intramuscularly or intravenously as prescribed.
• Do not self-administer; seek professional medical help.
• Avoid missing doses; complete the full course as prescribed.
• Inform your doctor if you have kidney or hearing issues before taking Kanamycin.
• Store Procaine Penicillin injection at room temperature, away from light and moisture.