KANACILLIN PLAIN INJ

Kanamycin, an aminoglycoside antibiotic, exerts its bactericidal effect by binding to the 30S subunit of bacterial ribosomes, disrupting protein synthesis. It achieves this by causing misreading of the genetic code and inhibiting translocation, leading to the production of faulty proteins. Procaine Penicillin, a beta-lactam antibiotic, acts by inhibiting the synthesis of the bacterial cell wall. It specifically targets penicillin-binding proteins (PBPs), which are essential for cross-linking peptidoglycan strands, thereby weakening the cell wall and compromising the structural integrity of the bacteria.

Kanamycin (Acid Sulphate) 100000IU, Procaine Penicillin 300mg

Aminoglycoside and Penicillin

Injection

The following are the uses of Kanamycin (Acid Sulphate) 100000IU, Procaine Penicillin 300mg Injection:

• Used for treating bacterial infections such as pneumonia, meningitis, and syphilis.
• Used for preventing infections during surgical procedures.
• Used for controlling infections in wounds and burns.
• Used for managing respiratory tract infections.
• Used for treating skin and soft tissue infections.
• Used for controlling infections in livestock and poultry.
• Used for research purposes in microbiology and antibiotic resistance studies.
• Used for its bactericidal properties against a range of gram-positive and gram-negative bacteria.

In the case of an overdose of Kanamycin (Acid Sulphate) 100000IU or Procaine Penicillin 300mg Injection, seek medical assistance promptly. Symptoms may include nausea, vomiting, hearing loss, and kidney issues. It is crucial to provide the healthcare provider with details such as the medication name, dosage taken, and the time of ingestion. They will determine the necessary treatment, which may involve supportive care and monitoring of vital functions.

In the case of a missed dose of Kanamycin (Acid Sulphate) 100000IU, administer the missed dose as soon as possible, but if it is almost time for the next dose, skip the missed dose and continue with the regular dosing schedule. For Procaine Penicillin 300mg Injection, if a dose is missed, inject the missed dose as soon as you remember, and then adjust the timing of the next dose accordingly, ensuring that the interval between doses is maintained. It is important to consult a healthcare professional if you frequently miss doses or have concerns about your medication schedule.

To administer Kanamycin (Acid Sulphate) 100000IU and Procaine Penicillin 300mg Injection, mix the contents of the vial with the provided diluent, gently swirl to dissolve, and then inject the entire mixture intramuscularly, following the prescribed dosage and administration schedule provided by your healthcare professional.

Following are the conditions or situations when Kanamycin (Acid Sulphate) 100000IU, Procaine Penicillin 300mg Injection should not be used:

• Should not be used in patients with a known allergy to Kanamycin, Procaine Penicillin, or any other aminoglycoside or penicillin antibiotics.
• Contraindicated in patients with a history of severe allergic reactions to any medication.
• Not recommended for patients with kidney disease or those receiving other medications that can affect kidney function.
• Should be avoided in patients with myasthenia gravis.
• Not suitable for patients with a history of gastrointestinal diseases or conditions such as ulcerative colitis or antibiotic-associated colitis.
• Should not be used in patients with a history of severe or life-threatening infections caused by bacteria resistant to penicillin.
• Contraindicated during breastfeeding, as both Kanamycin and Procaine Penicillin can pass into breast milk and may cause harm to the nursing infant.

The side effects of Kanamycin (Acid Sulphate) 100000IU and Procaine Penicillin 300mg Injection may include:

• Hearing loss or ringing in the ears (tinnitus)
• Dizziness
• Nausea and vomiting
• Kidney damage (nephrotoxicity)
• Muscle weakness
• Numbness or tingling in the hands and feet
• Allergic reactions, such as skin rash, itching, or hives
• Pain and inflammation at the injection site

Following are the precautions and warnings for Kanamycin (Acid Sulphate) 100000IU and Procaine Penicillin 300mg Injection:

• Patients with known allergies to aminoglycoside antibiotics or penicillins should not use this medication to avoid severe allergic reactions.
• Kanamycin can cause ototoxicity and nephrotoxicity; regular monitoring of kidney function and hearing is necessary during treatment.
• Procaine Penicillin should be used with caution in patients with a history of kidney or liver disease, as it may require dosage adjustments.
• Ensure the injection is administered intramuscularly and not intravenously to prevent adverse effects.
• Avoid using this medication if you have a history of gastrointestinal diseases, especially colitis, as it may exacerbate these conditions.
• Elderly patients may be more susceptible to the side effects of these medications; close monitoring is advised.
• Kanamycin and Procaine Penicillin should be used with caution during pregnancy and breastfeeding, only if the potential benefits outweigh the risks.
• Patients with neuromuscular disorders should exercise caution, as procaine may exacerbate these conditions.

Following are the drug interactions for Kanamycin (Acid Sulphate) 100000IU and Procaine Penicillin 300mg Injection:

• Neuromuscular blocking agents and Kanamycin may lead to prolonged neuromuscular blockade and respiratory depression.
• Kanamycin can enhance the nephrotoxic effects of other potentially nephrotoxic drugs, such as aminoglycosides, amphotericin B, and cisplatin.
• Procaine Penicillin may reduce the effectiveness of oral contraceptives, requiring alternative contraceptive methods.
• The risk of bleeding may increase when combined with anticoagulants or antiplatelet drugs.
• Concomitant use with other nephrotoxic medications like vancomycin or cyclosporine can exacerbate kidney damage.
• Kanamycin may interfere with the action of muscle relaxants, prolonging their effects during anesthesia.
• The effectiveness of live attenuated vaccines may be diminished when administered with Procaine Penicillin.

Following are the food interactions for Kanamycin (Acid Sulphate) 100000IU and Procaine Penicillin 300mg Injection:

• Alcohol intake should be minimized or avoided as it may increase the risk of side effects and impact the effectiveness of both Kanamycin and Procaine Penicillin.
• Grapefruit and its juice should be avoided as they can interfere with the metabolism of Kanamycin, potentially increasing its levels in the body and the risk of adverse effects.
• Dairy products, especially milk, may reduce the absorption of Procaine Penicillin if taken simultaneously. Separate the medication and dairy intake by a few hours.
• High-fiber foods can affect the absorption of both antibiotics; ensure a balanced diet but be mindful of excessive fiber intake during treatment.
• Vitamin K-rich foods like leafy greens may interfere with the effectiveness of Procaine Penicillin. Consult your healthcare provider for dietary advice.
• Avoid high-sodium foods, as Kanamycin can increase sodium levels in the body, potentially causing electrolyte imbalances.
• Ensure adequate hydration throughout the treatment period, especially with Kanamycin, to reduce the risk of kidney-related side effects.
• No significant food interactions have been reported to directly affect the absorption of these medications, but always follow the instructions provided by your healthcare professional for optimal results.

Kanamycin (Acid Sulphate) 100000IU and Procaine Penicillin 300mg Injection should be stored in a cool, controlled environment, preferably between 2-8°C (36-46°F) in a refrigerator, ensuring protection from light. It is crucial to keep the injections in their original packaging, tightly sealed, to maintain sterility and prevent contamination. Avoid freezing or exposing them to extreme heat, as this can compromise their effectiveness. When disposing of unused or expired medication, do not discard it with regular household waste or pour it down the drain. Instead, follow local guidelines for pharmaceutical waste disposal or consult your pharmacist for safe disposal options. Keep all medications securely stored, out of the reach of children and pets, to prevent accidental ingestion or exposure.

Following are the quick tips for Kanamycin (Acid Sulphate) 100000IU and Procaine Penicillin 300mg Injection:

• Consult a doctor for prescription and dosage instructions specific to your condition.
• Ensure the injection is administered by a trained medical professional.
• Inform your doctor about any allergies or medical conditions before receiving the injection.
• Stay well-hydrated before and after the injection to facilitate medication distribution.
• If you experience discomfort at the injection site, apply a cold compress for relief.
• Do not reuse needles or syringes; dispose of them safely.
• Store the injections as directed on the packaging, away from direct sunlight and moisture.