Kanamol (Paediatric) 60 Suspension

Paracetamol and tramadol work synergistically in this combination. Paracetamol exerts its analgesic effects primarily through inhibiting the synthesis of prostaglandins in the central nervous system, reducing pain sensitivity. Tramadol, a synthetic opioid, acts on the μ-opioid receptors in the brain and spinal cord, decreasing the perception of pain. Additionally, tramadol inhibits the reuptake of serotonin and norepinephrine, enhancing the body's natural pain-modulating systems. Together, these mechanisms provide effective pain relief by targeting multiple pathways involved in pain signaling and modulation.

Analgesic, Opioid Combination

Suspension

The following are the uses of Paracetamol 325mg, Tramadol 37.5mg Syrup/Suspension:

• Used for effective pain relief, targeting moderate to severe pain.
• Used to manage post-operative pain, ensuring patient comfort during recovery.
• Provides relief for chronic pain conditions, offering long-term management.
• Suitable for individuals with difficulty swallowing tablets, ensuring accessibility.
• Offers a convenient and easy-to-administer option for children and the elderly.
• Can be used as a standalone treatment or in combination with other medications.
• Helps reduce fever and provides comfort for those with influenza or other viral infections.
• Provides symptomatic relief, allowing individuals to resume daily activities with reduced pain.

In the case of an overdose of Paracetamol 325mg and Tramadol 37.5mg Syrup/Suspension, prompt medical intervention is necessary. Symptoms may include nausea, vomiting, abdominal pain, and potential liver damage. The severity of the overdose depends on the amount ingested, and medical professionals should be contacted immediately for guidance and treatment options. Timely action can prevent serious complications and ensure appropriate care.

In the case of a missed dose of Paracetamol 325mg, take the missed dose as soon as you remember, but if it is almost time for the next dose, skip the missed dose and continue with your regular dosing schedule. For Tramadol 37.5mg Syrup/Suspension, if a dose is missed, take it as soon as you remember, however, if it is close to the time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to make up for a missed one.

To administer Paracetamol 325mg and Tramadol 37.5mg Syrup/Suspension, shake the bottle well, measure the prescribed dose with an accurate measuring device, and take it orally as directed by your healthcare provider, ensuring you follow the recommended dosage instructions.

Here is a list of conditions and situations when Paracetamol 325mg and Tramadol 37.5mg Syrup/Suspension should not be used:

• Do not use in patients with known allergy or hypersensitivity to paracetamol, tramadol, or any of the excipients in the suspension.
• Avoid in patients with severe respiratory depression or asthma, as it can worsen breathing.
• Contraindicated in individuals with severe liver or kidney impairment.
• Not recommended for patients who have recently used alcohol, sedatives, tranquilizers, or other narcotic medications.
• Should not be used in children below a certain age (age limit may vary depending on medical guidelines).
• Do not use if you have a head injury, increased intracranial pressure, or a history of seizures.
• Contraindicated during breastfeeding, as it can pass into breast milk and may harm the baby.
• Avoid in patients with a history of suicidal thoughts or attempts.
• Do not use for patients who are undergoing treatment with Monoamine Oxidase Inhibitors (MAOIs).

The side effects of Paracetamol 325mg and Tramadol 37.5mg Syrup/Suspension may include:

• Nausea and vomiting
• Dizziness or lightheadedness
• Drowsiness
• Constipation
• Dry mouth
• Sweating
• Itching or skin rash
• Difficulty breathing (rare)

Following are the precautions and warnings for Paracetamol 325mg, Tramadol 37.5mg Syrup/Suspension:

• Do not exceed the recommended dosage, as excessive use can lead to liver damage.
• This medication should be used with caution in patients with liver or kidney disease, as it may require dosage adjustments.
• Avoid alcohol consumption while taking this medication, as it can increase the risk of liver damage and enhance the sedative effects of Tramadol.
• Patients with a history of seizures or those taking medications that lower the seizure threshold should use it with caution, as Tramadol may increase the risk of seizures.
• Not recommended for use in children below 12 years of age without medical supervision.
• Pregnant and breastfeeding women should consult a healthcare professional before using this medication, as it may have potential risks to the fetus or infant.
• Patients with respiratory issues should exercise caution, as Tramadol may cause respiratory depression in some individuals.
• Do not drive or operate heavy machinery until you know how this medication affects you, as it can cause dizziness and drowsiness.

Following are the drug interactions for Paracetamol 325mg, Tramadol 37.5mg Syrup/Suspension:

• Co-administration with other central nervous system (CNS) depressants (e.g., benzodiazepines, barbiturates, other opioids) can lead to increased sedation, respiratory depression, and potential overdose.
• Tramadol may enhance the effects of other opioids, and concomitant use can result in increased risk of respiratory depression and sedation.
• Paracetamol can interfere with the effectiveness of anticoagulants like warfarin, requiring close monitoring of INR (International Normalized Ratio).
• The syrup/suspension formulation may contain sorbitol, which can affect the absorption of some antibiotics, such as tetracyclines.
• Caution is advised when using with selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIs), as this combination may increase the risk of serotonin syndrome.
• Tramadol can interact with serotonergic drugs, such as triptans and certain antidepressants, increasing the risk of serotonin-related adverse effects.
• Avoid using with monoamine oxidase inhibitors (MAOIs) or within 14 days of stopping MAOIs to prevent potentially serious drug interactions.

Following are the food interactions for Paracetamol 325mg, Tramadol 37.5mg Syrup/Suspension:

• Avoid consuming alcohol while taking this medication, as it can increase the risk of liver damage and enhance the sedative effects of Tramadol.
• Grapefruit and grapefruit juice should be consumed with caution as they can affect the metabolism of Tramadol, potentially increasing its levels in the blood and leading to more side effects.
• High-fat meals may slightly delay the absorption of Tramadol, but it generally does not affect its overall effectiveness.
• Avoid caffeine-rich foods and beverages as they can potentially increase the metabolism of Tramadol, reducing its effectiveness.
• Avoid herbal remedies like St. John's Wort as it can interact with Tramadol and increase the risk of serotonin syndrome.
• Avoid excessive amounts of chocolate, as it contains a small amount of caffeine and theobromine, which can affect Tramadol's metabolism.
• There are no specific food restrictions for Paracetamol, but maintaining a balanced diet is advisable to support overall health.
• Always follow the dosage instructions provided by your healthcare professional, and inform them about any dietary concerns or changes.

Paracetamol 325mg and Tramadol 37.5mg Syrup/Suspension should be stored in a secure location, preferably a locked cabinet, at room temperature (68°F to 77°F or 20°C to 25°C) with brief excursions permitted between 59°F and 86°F (15°C and 30°C). Keep the medication away from direct sunlight, moisture, and heat sources such as stoves or heaters, as extreme temperatures can degrade the quality of the syrup. Always check the expiration date, and never use the medication beyond this date. When disposing of unused or expired syrup, do not pour it down the drain or flush it; instead, contact your local waste management authority or healthcare provider for guidance on safe disposal methods. Keep the medication out of children's reach to prevent accidental consumption.

Following are the quick tips for Paracetamol 325mg, Tramadol 37.5mg Syrup/Suspension:

• Always follow your healthcare provider's instructions for dosage and administration.
• Shake the bottle vigorously to ensure proper mixing before each use.
• Use a measuring cup or syringe provided to ensure accurate dosing.
• Take the syrup with water, avoiding hot beverages or dairy products for better absorption.
• Maintain a consistent schedule for taking the medication for best results.
• Store the syrup at room temperature, away from direct sunlight and moisture.
• Keep the medication in its original container and out of children's reach.
• Do not share your medication with others, even if they have similar symptoms.