KANDO 16MG TAB

Candesartan, the active ingredient in Candesartan 16mg Tablets, is an angiotensin II receptor blocker (ARB). Its primary mechanism of action is to selectively block the binding of angiotensin II to its receptors, specifically the AT1 receptors, found in many tissues, including vascular smooth muscle and the adrenal glands. Angiotensin II is a potent vasoconstrictor and stimulates the release of aldosterone, which regulates blood pressure. By blocking the effects of angiotensin II, candesartan reduces vasoconstriction and decreases the release of aldosterone, leading to relaxation of blood vessels and a decrease in blood pressure. This mechanism helps to lower blood pressure by promoting vasodilation, reducing peripheral resistance, and decreasing the workload on the heart, ultimately improving blood flow and cardiac output.

Candesartan 16mg

Angiotensin II receptor blocker.

Tablet

The following are the uses of Candesartan 16mg Tablet:

• Used for treating high blood pressure (hypertension).
• Used to lower blood pressure and reduce strain on the heart.
• Used for managing heart failure, improving symptoms and preventing further deterioration.
• Used to reduce the risk of cardiovascular events like heart attacks and strokes in certain patients.
• Used to improve blood flow and kidney function in patients with diabetes and hypertension.
• Used as part of a comprehensive treatment plan for cardiovascular health.
• Used to help patients with hypertension live healthier lives by controlling blood pressure effectively.

In the case of an overdose of Candesartan 16mg Tablets, it is important to remain calm and take swift action. Contact a healthcare professional or a poison control center for guidance. Symptoms of an overdose may include low blood pressure, dizziness, and fainting. Promptly seeking medical advice can help manage any potential complications and ensure appropriate treatment is provided. It is crucial to keep medications out of reach to prevent accidental ingestion, especially for children.

In the case of a missed dose of Candesartan 16mg Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you frequently miss doses, it's best to set reminders or use a pill organizer to help you stay on track. It is crucial to maintain a consistent medication routine for the treatment's effectiveness.

To take Candesartan 16mg Tablet, swallow the tablet whole with a glass of water, preferably at the same time each day, as directed by your healthcare provider, and do not crush, chew, or break the tablet.

Following are the conditions or circumstances when Candesartan 16mg Tablet should not be taken:

• Must not be taken by individuals with a known allergy or hypersensitivity to Candesartan or any other angiotensin II receptor blockers (ARBs).
• Not suitable for patients with a condition called bilateral renal artery stenosis (narrowing of the arteries supplying the kidneys).
• Contraindicated in pregnant women, especially during the second and third trimesters, as it can cause harm to the fetus.
• Should not be used in individuals with severe liver disease or biliary obstruction (blockage in the liver's bile ducts).
• Not recommended for children below 1 year of age due to a lack of sufficient data regarding its safety and efficacy.
• Should be avoided in patients with severe kidney disease or those on dialysis, as dosage adjustments may not be sufficient to ensure safety.

The side effects of Candesartan 16mg Tablet may include:

• Dizziness
• Fatigue or tiredness
• Headache
• Nausea and vomiting
• Diarrhea
• Muscle cramps
• Elevated potassium levels in the blood (hyperkalemia)
• Low blood pressure (hypotension)

Following are the precautions and warnings for Candesartan 16mg Tablet:

• Candesartan should not be used in patients with a known allergy or hypersensitivity to the medication or any of its components.
• Patients with a history of kidney or liver disease should exercise caution and have regular monitoring, as Candesartan can affect these organs.
• Elderly patients may be more susceptible to the effects of Candesartan, so dosage adjustments might be necessary.
• This medication may cause dizziness or lightheadedness, especially when standing up from a sitting or lying position. Patients should stand up slowly to prevent falls.
• Candesartan may cause an increase in potassium levels in the blood, so regular monitoring is advised, especially in patients with kidney disease or those taking potassium-sparing diuretics.
• It should be used with caution in patients with a history of low blood pressure, as it may further lower blood pressure, especially when initiating therapy.
• Pregnant or breastfeeding women should consult their doctor before taking Candesartan, as it may not be suitable during these periods.
• If you experience any symptoms of angioedema, such as swelling of the face, lips, tongue, or throat, seek immediate medical attention and discontinue the medication.

Following are the drug interactions for Candesartan 16mg Tablet:

• Candesartan can lead to increased potassium levels when used with angiotensin-converting enzyme (ACE) inhibitors, potassium-sparing diuretics, or potassium supplements.
• Nonsteroidal anti-inflammatory drugs (NSAIDs) may reduce the antihypertensive effect of Candesartan.
• The combination of Candesartan with other antihypertensive medications, such as beta-blockers or diuretics, can result in additive effects and potentially cause excessive blood pressure lowering.
• Drugs affecting renal function, like NSAIDs or diuretics, might reduce the efficacy of Candesartan.
• Candesartan may enhance the hypoglycemic effects of insulin or oral antidiabetic agents, especially in patients with renal impairment.
• The use of Candesartan with other drugs that block the renin-angiotensin system, including aliskiren, can lead to increased risks of hypotension, hyperkalemia, and renal dysfunction.
• Candesartan may interact with lithium, potentially increasing lithium levels and the risk of lithium toxicity.
• Drugs that inhibit or induce CYP2C9 enzyme activity can affect the metabolism of Candesartan, altering its effectiveness.

Following are the food interactions for Candesartan 16mg Tablet:

• Candesartan can interact with high-potassium foods like bananas, oranges, tomatoes, and spinach. Consuming excessive amounts of these foods may increase potassium levels in the blood.
• Grapefruit and grapefruit juice should be consumed with caution as they can affect the metabolism of Candesartan, potentially increasing its levels in the blood.
• Alcohol intake may lead to further lowering of blood pressure, especially when consuming large amounts, which can cause dizziness and lightheadedness.
• Avoid excessive salt or sodium-rich foods, as Candesartan may decrease the body's ability to eliminate excess salt, leading to increased blood pressure.
• Candesartan may cause potassium levels to rise; therefore, potassium-rich foods like avocados, mushrooms, and sweet potatoes should be consumed in moderation.
• There is no significant interaction with dairy products, but calcium-rich foods should be consumed as part of a balanced diet.
• Stay well-hydrated, especially in hot weather or during intense physical activity, to maintain blood pressure regulation.
• Consult your doctor or pharmacist for personalized advice regarding dietary considerations while taking Candesartan.

Candesartan 16mg tablets should be stored in a cool and dry place, preferably at room temperature, ensuring protection from direct sunlight and moisture. Keep the tablets in their original packaging, tightly sealed, to maintain their integrity and prevent exposure to external elements. It is crucial not to store the medication in bathrooms or near heat-emitting appliances, as temperature fluctuations can impact its effectiveness. When disposing of unused or expired tablets, refrain from flushing them down the toilet or pouring them into drainage systems. Instead, consult your pharmacist or healthcare professional for appropriate disposal methods to minimize environmental impact. Always keep the medication out of children's reach to prevent accidental consumption.

Following are the quick tips for Candesartan 16mg Tablet:

• Consult your doctor before starting this medication, especially if you have kidney or liver problems.
• Take the tablet as directed by your doctor, typically once daily.
• Consistency is key; take it at the same time each day for better effectiveness.
• Ensure you swallow the tablet whole with a full glass of water, making it easier to swallow.
• Avoid crushing or chewing the tablet as it may affect its absorption.
• Do not stop taking the medication abruptly; consult your doctor for dosage adjustments.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.