KANDO 8MG TAB

Candesartan, the active ingredient in Candesartan 8mg Tablets, acts as a selective AT1 receptor antagonist. It specifically targets the angiotensin II type 1 (AT1) receptors, which play a crucial role in the renin-angiotensin-aldosterone system (RAAS). By blocking these receptors, candesartan effectively inhibits the binding of angiotensin II, a potent vasoconstrictor hormone. This mechanism leads to vasodilation, reducing peripheral vascular resistance and lowering blood pressure. Candesartan's ability to selectively block AT1 receptors makes it effective in treating hypertension by promoting relaxation and widening of blood vessels, ultimately improving blood flow and reducing the workload on the heart.

Candesartan 8mg

Angiotensin II receptor blocker.

Tablet

The following are the uses of Candesartan 8mg Tablet:

• Used for treating high blood pressure (hypertension)
• Used to lower blood pressure and reduce strain on the heart
• Used in cases of heart failure, improving symptoms and reducing hospital admissions
• Used as an angiotensin receptor blocker, relaxing blood vessels and improving blood flow
• Used to prevent kidney damage and slow down the progression of kidney disease
• Used to improve survival rates and quality of life in heart and kidney-related conditions
• Used as a long-term treatment to manage chronic conditions effectively

In the case of an overdose of Candesartan 8mg Tablets, it is important to recognize the potential symptoms, which may include dizziness, low blood pressure, and increased heart rate. The severity of the overdose effects can vary depending on the amount ingested. If an overdose is suspected, seek medical advice promptly. Treatment may involve supportive measures to manage symptoms and ensure the patient's vital signs remain stable until the excess medication is cleared from the system.

In the case of a missed dose of Candesartan 8mg Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss several doses, contact your healthcare provider for advice on how to safely resume your medication and maintain its effectiveness. It is generally recommended to take the missed dose within a 12-hour window from the time it was due.

To take Candesartan 8mg Tablet, swallow the tablet whole with a glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare professional.

Following are the conditions when Candesartan 8mg Tablet should not be used:

• Must not be used in patients with a known allergy or hypersensitivity to Candesartan or any other angiotensin II receptor blockers (ARBs).
• Contraindicated in pregnant women, especially during the second and third trimesters, as it can cause harm to the fetus.
• Should not be used in individuals with severe liver disease or biliary obstruction, as it can lead to increased drug levels in the body.
• Not recommended for patients with bilateral renal artery stenosis or unilateral stenosis in a solitary kidney, as it may worsen kidney function.
• Avoid using in patients with a history of angioedema, whether associated with previous angiotensin-converting enzyme (ACE) inhibitor/ARB therapy or not.
• Should not be administered to patients with severe, life-threatening cardiac failure or those who are fluid-depleted, as it can cause hypotension.

The side effects of Candesartan 8mg Tablet may include:

• Dizziness
• Headache
• Fatigue or weakness
• Nausea and vomiting
• Diarrhea or abdominal pain
• Muscle cramps
• Increased sensitivity to sunlight

Following are the precautions and warnings for Candesartan 8mg Tablet:

• Not recommended for individuals with a known allergy to Candesartan or any other angiotensin II receptor blockers.
• Patients with a history of kidney or liver disease should exercise caution and have regular monitoring, as Candesartan may affect renal and hepatic function.
• Blood pressure should be monitored regularly, especially in patients with low blood pressure or those who are dehydrated.
• Not suitable for use during pregnancy or breastfeeding, and alternative treatments should be considered.
• Elderly patients may be more susceptible to the effects of Candesartan, particularly on kidney function and blood pressure.
• Discontinuing the medication abruptly may lead to a rapid rise in blood pressure, so the dosage should be gradually reduced.
• May cause dizziness or lightheadedness, so patients should be cautious when standing up or performing tasks that require alertness.

Following are the drug interactions for Candesartan 8mg Tablet:

• Candesartan may interact with other blood pressure medications like ACE inhibitors (e.g., enalapril) or diuretics (e.g., hydrochlorothiazide), potentially causing excessive blood pressure drop.
• The effect of Candesartan may be reduced when used with NSAIDs (nonsteroidal anti-inflammatory drugs) like ibuprofen, leading to decreased blood pressure control.
• Lithium levels in the blood can be increased when taken with Candesartan, which may require dose adjustments.
• Candesartan can enhance the blood pressure-lowering effect of other antihypertensive drugs, including beta-blockers and alpha-blockers.
• Drugs that affect the renin-angiotensin system, such as aliskiren, should not be used concurrently with Candesartan due to the risk of kidney damage.
• The effectiveness of Candesartan may be reduced when used with certain analgesics, like acetaminophen, potentially requiring dosage adjustments.
• Caution is advised when combining Candesartan with potassium-sparing diuretics, as it may increase serum potassium levels.

Following are the food interactions to consider with Candesartan 8mg Tablet:

• Alcohol consumption should be limited or avoided as it may increase the risk of hypotension (low blood pressure) and dizziness.
• High-sodium foods like processed snacks, canned soups, and fast food should be reduced as Candesartan may cause increased sodium excretion.
• Foods rich in potassium like bananas, oranges, and spinach should be consumed in moderation as Candesartan can increase potassium levels.
• Grapefruit and grapefruit juice should be avoided as they may affect the metabolism of Candesartan, altering its effectiveness.
• Salt substitutes or potassium-rich salt alternatives should be used cautiously as they can increase potassium levels.
• Licorice can decrease the effectiveness of Candesartan and should be avoided or consumed in moderation.
• A balanced diet is recommended, focusing on fruits, vegetables, whole grains, and lean proteins to support overall health while taking Candesartan.

Candesartan 8mg Tablets should be stored in a cool and dry place, preferably at room temperature, ensuring protection from light and moisture. It is crucial to keep the tablets in their original packaging, tightly sealed, to maintain their integrity and prevent contamination. Avoid storing them in the bathroom or kitchen, as temperature fluctuations and humidity can impact their effectiveness. Always check the expiration date before use, and do not use the medication if it is past its expiry. When disposing of unused or expired tablets, do not flush them or throw them into the trash. Instead, follow local guidelines for pharmaceutical waste disposal or consult a pharmacist for safe disposal methods. Keep the medication away from children to prevent accidental consumption.

Following are the quick tips for Candesartan 8mg Tablet:

• Consult your doctor before taking this medication, especially if you have kidney or liver problems.
• Take the tablet as directed by your doctor, typically once daily.
• Consume the tablet with a glass of water, and it can be taken with or without food.
• Maintain a consistent time for taking the medication daily for better effectiveness.
• Avoid consuming alcohol as it may increase side effects and decrease blood pressure.
• Inform your doctor about all medications you're taking to prevent potential interactions.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.