KAPSIN GEL

Colchicum 0.040% w/w and Natural Capsicum Extract 0.00075% in a gel formulation work synergistically to provide pain relief. Colchicum acts by inhibiting the formation of tubulin, disrupting mitosis, and reducing inflammation. It interferes with the microtubule network within cells, leading to decreased cell division and migration, particularly in inflammatory cells. Capsaicin, the active component of Capsicum extract, binds to transient receptor potential vanilloid subtype 1 (TRPV1) receptors on sensory nerve fibers. This binding causes a temporary depletion of substance P, a neurotransmitter involved in pain signaling, resulting in desensitization of the nerve fibers and reduced pain perception.

Topical analgesic gel

Gel

The following are the uses of colchicum 0.040% w/w, Natural Capicum extract 0.00075 Gel:

• Used for treating acute gout and gout flares.
• Used as a topical analgesic to provide temporary relief from minor aches and pains of muscles and joints.
• Used for reducing inflammation and pain in affected areas.
• Used for managing pain and swelling associated with rheumatoid arthritis.
• Used for its ability to inhibit cell division, particularly in the treatment of certain types of cancer.
• Used as a counter-irritant to reduce pain and discomfort.
• Used for its anti-inflammatory properties, helping to reduce redness and swelling.
• Used to improve mobility and flexibility in affected joints.

In the case of an overdose of Colchicum 0.040% w/w and Natural Capsicum extract 0.00075% Gel, seek medical assistance promptly. Symptoms may include gastrointestinal issues, skin reactions, and organ toxicity. Prompt treatment can manage symptoms effectively. Ensure you provide the product details and dosage information to the healthcare professional for appropriate treatment. Immediate action is vital for a positive outcome.

In the case of a missed dose of Colchicum 0.040% w/w gel, apply the gel as soon as you remember. You can gently massage the gel into the affected area, ensuring complete absorption. If it's almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. For the Natural Capicum Extract 0.00075% gel, apply the missed dose as soon as possible, but avoid applying additional gel to make up for the missed application. Resume your regular application schedule after the missed dose.

To apply the Colchicum 0.040% w/w and Natural Capicum extract 0.00075% Gel, gently squeeze a small amount onto your fingertip and apply a thin layer to the affected area of the skin, rubbing it in gently until it is absorbed.

Following are the conditions or situations when Colchicum 0.040% w/w and Natural Capsicum extract 0.00075% Gel should not be used:

• Avoid using this gel if you have an active skin infection or open wounds at the site of application.
• Do not use if you have a known allergy or sensitivity to any of the ingredients, including Colchicum autumnale and Capsicum annuum.
• Not suitable for individuals with severe or uncontrolled cardiovascular diseases.
• Should not be used on broken or damaged skin.
• Avoid contact with eyes, mouth, and mucous membranes.
• Not recommended for children and elderly individuals without medical advice.
• Do not use this gel if you are planning to undergo or have recently undergone skin exfoliation treatments like chemical peels or laser therapy.
• Discontinue use if you experience severe burning, stinging, or skin irritation after applying the gel.

The side effects of Colchicum 0.040% w/w Natural Capsicum Extract 0.00075 Gel may include:

• Skin irritation or redness
• Burning or stinging sensation at the application site
• Allergic reactions such as itching or rash
• Dryness or peeling of the skin
• Increased sensitivity to heat or sunlight
• Temporary discomfort or warmth upon application

Following are the precautions and warnings for Colchicum 0.040% w/w and Natural Capsicum extract 0.00075% Gel:

• Avoid contact with eyes, nose, mouth, and other sensitive areas. In case of accidental contact, rinse thoroughly with water.
• Do not apply to broken or irritated skin. Discontinue use if skin irritation or rash occurs.
• Wash hands thoroughly after applying the gel to avoid accidental transfer to sensitive areas.
• Keep out of reach of children. Store in a cool, dry place, away from direct sunlight.
• Do not use this medication if you are allergic to colchicum or capsicum extracts or any other ingredients in the gel.
• Consult a healthcare professional if you are pregnant, breastfeeding, or planning to become pregnant before using this product.
• This gel is for external use only. Do not ingest or apply to large areas of the body.

Following are the drug interactions for Colchicum 0.040% w/w and Natural Capicum Extract 0.00075% Gel:

• Colchicum can interact with P-glycoprotein (P-gp) and CYP3A4 inhibitors, such as clarithromycin, verapamil, and ketoconazole, leading to increased colchicine levels and potential toxicity.
• Nonsteroidal anti-inflammatory drugs (NSAIDs) and salicylates may increase the risk of gastrointestinal side effects when used with colchicum.
• The gel may enhance the absorption of other topical medications, increasing the risk of adverse effects.
• Drugs that lower the seizure threshold, such as certain antidepressants and antipsychotics, may have their effects potentiated.
• Concomitant use with macrolide antibiotics like erythromycin can increase colchicine exposure and the risk of toxicity.
• It may interact with CYP3A4 inducers, such as rifampin, reducing colchicine levels and potentially decreasing its effectiveness.
• Caution is advised when using with other drugs that cause diarrhea, as this may exacerbate gastrointestinal symptoms.

Following are the food interactions for Colchicum 0.040% w/w and Natural Capicum extract 0.00075 Gel:

• Citrus fruits like grapefruit and their juices should be consumed with caution as they may interfere with the medication's metabolism, potentially affecting its effectiveness.
• Spicy foods containing chili or peppers should be approached with care as they might exacerbate skin sensitivity, especially when using capsaicin-containing products.
• Alcohol should be limited or avoided as it can increase the risk of gastrointestinal irritation and may also interact with certain ingredients in the medication.
• Dairy products and high-fat meals can potentially delay the absorption of certain compounds, but this may not significantly impact the overall effectiveness of the treatment.
• Garlic and onion-rich foods may interact with blood-thinning properties, if any, present in the medication, and should be consumed in moderation.
• Caffeinated beverages like coffee and tea might heighten sensitivity and should be consumed in moderation to prevent potential side effects.
• Maintaining a balanced diet rich in antioxidants and anti-inflammatory foods can complement the treatment and promote overall health.
• Always consult with a healthcare professional for personalized advice regarding specific dietary considerations and potential interactions.

Colchicum 0.040% w/w and Natural Capicum extract 0.00075% Gel should be stored in a cool, dry area, away from sunlight and moisture. The gel should be tightly sealed in its original container to maintain its integrity and prevent contamination. It is crucial to avoid exposing the gel to extreme temperatures, so refrain from storing it in hot or humid environments. Properly discard any unused or expired gel, avoiding disposal in sinks or toilets. For safe disposal methods, consult a pharmacist or healthcare professional. Ensure the gel is kept away from children to prevent accidental contact or ingestion.

Following are the quick tips for Colchicum 0.040% w/w and Natural Capicum Extract 0.00075 Gel:

• Apply the gel as directed by your healthcare professional, ensuring you follow the recommended dosage.
• Wash your hands before and after application to maintain hygiene.
• Clean and dry the affected area before applying the gel.
• Use a thin layer and gently massage it into the skin for better absorption.
• Avoid contact with eyes, nose, and mouth. If contact occurs, rinse thoroughly with water.
• Do not apply to broken or irritated skin.
• Store the gel in a cool, dry place, away from direct sunlight and out of children's reach.