KEFADIM 1MG INJ

Ceftazidime is a beta-lactam antibiotic that primarily acts by inhibiting bacterial cell wall synthesis. Its mechanism of action involves binding to penicillin-binding proteins (PBPs), which are essential for cross-linking peptidoglycan strands in the bacterial cell wall. By specifically targeting PBPs, ceftazidime disrupts the final stages of cell wall synthesis, leading to the weakening and eventual lysis of the bacterial cell wall. This antibiotic has a broad spectrum of activity against a wide range of Gram-positive and Gram-negative bacteria, including Pseudomonas aeruginosa, by interfering with the transpeptidation reaction required for the formation of a strong and stable cell wall structure.

Ceftazidime 1000mg

Third-generation cephalosporin

Injection

The following are the uses of Ceftazidime 1000mg injection:

• Used for treating severe bacterial infections such as pneumonia, meningitis, and skin or abdominal infections.
• Used for its effectiveness against a broad range of bacteria, including Pseudomonas aeruginosa.
• Used for hospital-acquired infections, particularly in patients with weakened immune systems.
• Used as an alternative for patients allergic to penicillin or other antibiotics.
• Used to prevent infections during high-risk surgeries or medical procedures.
• Used to treat complicated urinary tract infections that have spread to the kidneys.
• Used in combination with other antibiotics for aggressive treatment of resistant infections.
• Used under strict medical supervision due to potential side effects and the risk of antibiotic resistance.

In the case of an overdose of Ceftazidime 1000mg injection, immediate medical attention is necessary. Symptoms may include nausea, vomiting, diarrhea, and in severe cases, seizures or kidney damage. Promptly seek medical advice, as treatment options may involve supportive care, monitoring vital signs, and ensuring adequate hydration. Quick action can help mitigate the risks associated with overdosing on this medication.

In the case of a missed dose of Ceftazidime 1000mg injection, it is important to administer the medication as soon as possible. If it is almost time for the next scheduled dose, skip the missed dose and continue with the regular dosing schedule. Do not double the dose to make up for a missed one. However, if multiple doses have been missed, contact your healthcare provider for guidance on how to proceed with the treatment. It is crucial to maintain a consistent medication routine for optimal effectiveness.

To administer Ceftazidime 1000mg injection, reconstitute the powder with the provided sterile water, gently swirl until dissolved, and inject the entire contents intramuscularly or intravenously as directed by your healthcare professional, ensuring proper aseptic technique and following the recommended dosage schedule.

Following are the conditions/situations when Ceftazidime 1000mg injection should not be administered:

• Must not be used in patients with a confirmed severe hypersensitivity or allergic reaction to Ceftazidime or other cephalosporin antibiotics.
• Not recommended for patients with a history of severe allergic reactions to penicillins, as there may be cross-reactivity.
• Contraindicated in patients with confirmed or suspected infectious mononucleosis, as it is not effective against the virus causing this condition.
• Should not be used in patients with a history of severe or life-threatening diarrhea caused by antibiotic use.
• Not suitable for patients with a known or suspected Clostridium difficile infection.
• Should be avoided in patients with a history of severe renal impairment or kidney disease, as dosage adjustments are necessary.
• Not recommended for patients with a history of severe gastrointestinal disorders or recent abdominal surgery.

The side effects of Ceftazidime 1000mg injection may include:

• Nausea and vomiting
• Diarrhea
• Skin rashes or itching
• Headache
• Dizziness
• Injection site reactions (pain, swelling, or redness)
• Allergic reactions (hives, difficulty breathing, swelling of the face/lips/tongue)
• Changes in liver function tests

Following are the precautions and warnings for Ceftazidime 1000mg Injection:

• This medication is intended for intravenous or intramuscular use only; it should never be administered orally or subcutaneously.
• Ceftazidime should be used with caution in patients with a history of allergic reactions to penicillin or other beta-lactam antibiotics, as cross-sensitivity may occur.
• Patients with severe renal impairment may require dosage adjustments, and kidney function should be closely monitored during treatment.
• Prolonged use of Ceftazidime may lead to the overgrowth of resistant microorganisms; monitor for signs of superinfection.
• Ensure proper hydration during treatment, especially in elderly patients or those with renal impairment.
• If seizures or neurological symptoms occur, discontinue the drug and provide appropriate medical care.
• This medication may cause false-positive results for galactosemia testing; consider alternative testing methods if necessary.
• Patients with a history of gastrointestinal diseases should be closely monitored for potential adverse effects on the digestive system.

Following are the drug interactions for Ceftazidime 1000mg injection:

• Probenecid can decrease the renal excretion of ceftazidime, leading to increased serum levels.
• Nephrotoxicity risk may increase when used with other nephrotoxic drugs like aminoglycosides or furosemide.
• Ceftazidime may reduce the effectiveness of oral contraceptives, leading to breakthrough bleeding and potential contraceptive failure.
• It can interfere with certain urine glucose tests, resulting in false-positive readings.
• Concurrent use with valproic acid may decrease the seizure threshold.
• The efficacy of live bacterial vaccines may be reduced, such as typhoid vaccine.
• Ceftazidime can potentially enhance the anticoagulant effect of warfarin, requiring close monitoring of INR.

Following are the food interactions for Ceftazidime 1000mg injection:

• Avoid consuming excessive amounts of alcohol during treatment, as it may increase the risk of liver-related side effects and decrease the effectiveness of the antibiotic.
• Grapefruit and grapefruit juice should be consumed with caution as they can affect the absorption and metabolism of Ceftazidime, potentially leading to increased drug levels in the body.
• Avoid high-fat meals before or after taking the injection, as it may slow down the absorption of the medication.
• Ensure adequate hydration and maintain a balanced diet to support overall health during the course of treatment.
• Avoid foods or beverages with high sugar content, as Ceftazidime can interact with sugary substances, potentially affecting its effectiveness.
• There is no specific food interaction requiring the medication to be taken on an empty stomach. However, follow the healthcare provider's instructions for administration.
• Generally, maintaining a healthy and balanced diet is recommended to support the immune system during antibiotic treatment.

Ceftazidime 1000mg injection should be stored properly to maintain its effectiveness and ensure patient safety. Keep the injection vials in a cool, dry place, preferably at room temperature between 68°F and 77°F (20°C and 25°C), and protect them from light and moisture. It is crucial to store the medication in its original packaging, ensuring the seal is intact to prevent contamination. Do not refrigerate or freeze the injection as it may affect its potency. Always check the expiration date before use, and discard any unused or expired medication responsibly. Proper disposal methods are essential, so do not flush or pour the injection down the drain; consult a pharmacist or healthcare professional for guidance on safe disposal practices. Keep the medication out of children's reach to prevent accidental exposure.

Following are the quick tips for Ceftazidime 1000mg injection:

• Administer the injection under medical supervision as prescribed.
• Ensure the injection is prepared and administered by a trained healthcare professional.
• Confirm the correct dosage and injection site as instructed by your healthcare provider.
• Before injection, clean the injection site with an alcohol swab to prevent infection.
• Dispose of used needles and syringes safely in designated sharps containers.
• If you experience any discomfort or pain during or after the injection, inform your healthcare provider.
• Store the injection as directed on the packaging, typically at room temperature and away from direct sunlight.