Kefzol (1g) 1 Vial Injection

Cephazolin is a bactericidal antibiotic belonging to the cephalosporin class. Its primary mechanism of action is inhibiting bacterial cell wall synthesis. Cephazolin binds to and blocks the activity of penicillin-binding proteins (PBPs), which are essential enzymes responsible for cross-linking peptidoglycan strands in the bacterial cell wall. By inhibiting PBPs, Cephazolin disrupts the formation of a strong and stable cell wall, leading to cell lysis and bacterial death. This antibiotic is particularly effective against a wide range of gram-positive and some gram-negative bacteria, making it a valuable agent in the treatment of various infections.

Cephazolin 1000mg

Cephalosporin antibiotic

injection

The following are the uses of Cephazolin 1000mg injection:

• Used for treating severe bacterial infections like bone, joint, skin, and urinary tract infections.
• Used for surgical prophylaxis to prevent infections during and after surgery.
• Used for treating infections caused by susceptible bacteria, including Staphylococcus and Streptococcus species.
• Used for managing infections in patients with weakened immune systems.
• Used for controlling infection spread in specific medical conditions.
• Used for its effectiveness against a broad range of bacteria, ensuring comprehensive treatment.

In the case of an overdose of Cephazolin 1000mg injection, it is important to act swiftly. Seek medical assistance promptly and provide the healthcare professional with all relevant information, including the dosage taken. They may induce vomiting or administer activated charcoal to mitigate the effects. Monitor vital signs and seek immediate treatment for any adverse reactions, as prompt intervention can significantly reduce the risks associated with overdosing on this medication.

In the case of a missed dose of Cephazolin 1000mg injection, it is important to administer the medication as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and continue with the regular dosing schedule. However, do not double the dose to make up for a missed one. If you have missed multiple doses, contact your healthcare provider for guidance on how to safely resume the medication and ensure the best possible treatment outcome. It is crucial to follow the prescribed dosing regimen for this medication to maintain its effectiveness.

To administer Cephazolin 1000mg injection, clean the injection site with an alcohol swab, insert the needle at a 90-degree angle, inject the entire content of the vial slowly, and then safely dispose of the used needle and syringe.

Following are the conditions or situations when Cephazolin 1000mg injection should not be administered:

• Must not be used in individuals with a confirmed allergy to Cephazolin or other cephalosporin antibiotics.
• Not suitable for patients with a history of severe hypersensitivity reactions to penicillins, as cross-reactivity may occur.
• Contraindicated in patients with a history of severe gastrointestinal diseases, especially colitis.
• Should not be used in patients with a known history of seizures or other neurological disorders.
• Not recommended for individuals with severe kidney impairment or kidney failure.
• Avoid in patients with a known or suspected infection caused by microorganisms resistant to Cephazolin.
• Must not be administered if the patient has a history of severe cardiovascular disease or unstable blood pressure.

The side effects of Cephazolin 1000mg injection may include:

• Skin rashes or itching
• Diarrhea
• Nausea and vomiting
• Pain or swelling at the injection site
• Headache
• Dizziness
• Allergic reactions, including hives and difficulty breathing
• Kidney problems, resulting in decreased urine output

Following are the precautions and warnings:

• Cephazolin 1000mg injection should not be administered to individuals with a history of allergic reactions to penicillins, cephalosporins, or any other beta-lactam antibiotics. Severe allergic reactions can occur and immediate medical attention is required if anaphylaxis or severe hypersensitivity reactions develop.
• Prolonged use of Cephazolin may lead to the overgrowth of non-susceptible organisms, including fungi. Discontinue use if superinfection occurs.
• Patients with a history of gastrointestinal diseases, particularly colitis, should be closely monitored for possible recurrence during and after treatment.
• Renal function should be monitored during prolonged therapy, and dosage adjustments may be necessary in patients with impaired renal function.
• Caution is advised in patients with a history of kidney disease as it is primarily excreted through the kidneys.
• Cephazolin should be used with caution in individuals with a history of allergies, asthma, or hay fever, as they may be more susceptible to allergic reactions.
• This medication should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
• It is not known if Cephazolin passes into breast milk, so caution should be exercised when considering its use in breastfeeding women.

Following are the drug interactions for Cephazolin 1000mg injection:

• Concurrent use with other nephrotoxic drugs (e.g., aminoglycosides, amphotericin B) may increase the risk of kidney damage.
• Cephazolin can reduce the effectiveness of oral contraceptives, requiring alternative birth control methods.
• It may enhance the anticoagulant effect of warfarin, requiring close monitoring of INR.
• Cephazolin can alter the efficacy of methotrexate, requiring dosage adjustments.
• The risk of bleeding may increase when combined with antiplatelet drugs like clopidogrel.
• Probenecid can decrease the renal excretion of Cephazolin, potentially increasing its serum levels.
• Live attenuated vaccines may have reduced effectiveness when administered during Cephazolin treatment.

Following are the food interactions for Cephazolin 1000mg injection:

• Alcohol consumption should be avoided as it can increase the risk of liver damage and may interfere with the antibiotic's effectiveness.
• Avoid grapefruit and grapefruit juice as they can alter the drug's metabolism, leading to increased levels of Cephazolin in the body.
• High-fiber foods like whole grains, legumes, and nuts can reduce the absorption of Cephazolin, so it is best to take the medication on an empty stomach.
• Dairy products may interfere with the absorption of Cephazolin, so consider separating milk, cheese, and yogurt consumption from medication timing.
• Vitamin K-rich foods such as leafy greens may reduce the effectiveness of Cephazolin, so ensure a balanced diet is maintained.
• Avoid excessive caffeine intake, as it can increase the risk of side effects such as nervousness and tremors.
• Stay well-hydrated by drinking plenty of fluids, especially water, to support kidney function while on this medication.

Cephazolin 1000mg injection should be stored in a controlled environment, preferably between 68°F and 77°F (20°C and 25°C). Protect it from light and excessive heat, and avoid freezing temperatures. Ensure the injection is kept in its original packaging, tightly sealed, to maintain sterility. It is crucial not to use the injection if the solution appears discolored or contains particles. Once the vial is opened, any unused portion should be discarded promptly to minimize the risk of contamination. Disposal of unused medication should be done responsibly; do not pour it down the drain or flush it into the sewage system. Instead, follow local guidelines for pharmaceutical waste disposal or consult a healthcare professional for advice on safe disposal methods. Keep this medication out of children's reach to prevent accidental exposure.

Following are the quick tips for Cephazolin 1000mg injection:

• Ensure the injection is administered by a trained healthcare professional.
• Verify the medication and dosage accuracy before injection.
• Cephazolin is typically given intravenously, follow the prescribed route.
• Do not mix with other medications unless instructed by a doctor.
• Report any signs of allergic reaction immediately.
• Store the injection as directed on the packaging, usually at room temperature.
• Do not use if the solution appears discolored or contains particles.