Kefzol (500mg) 1 Vial Injection

Cephazolin is a first-generation cephalosporin antibiotic that exerts its bactericidal effect by inhibiting the synthesis of the bacterial cell wall. It primarily targets penicillin-binding proteins (PBPs) in susceptible bacteria, which are essential for cross-linking peptidoglycan strands during cell wall formation. By binding to these PBPs, Cephazolin interferes with the transpeptidation reaction, preventing the formation of a strong and stable bacterial cell wall. This disruption leads to cell wall defects, resulting in the weakening and eventual lysis of the bacterial cell. Cephazolin has a broad spectrum of activity against a wide range of gram-positive and some gram-negative bacteria, making it effective in treating various infections caused by susceptible organisms.

Cephazolin 500mg

Cephalosporin antibiotic

injection

The following are the uses of Cephazolin 500mg injection:

• Used for treating serious bacterial infections like bone, joint, skin, and urinary tract infections.
• Used for surgical prophylaxis to prevent infections during high-risk procedures.
• Used for treating bacterial pneumonia and lung abscesses.
• Used for bloodstream infections (bacteremia) caused by susceptible organisms.
• Used for endocarditis, a heart valve infection, when caused by specific bacteria.
• Used for preventing infection in open fractures and animal bites.
• Used for skin structure infections, including cellulitis and abscesses.
• Used for empirical therapy in severe infections before the exact organism is identified.

In the case of an overdose of Cephazolin 500mg injection, it is important to recognize the potential risks and take appropriate action. Symptoms may include nausea, vomiting, diarrhea, and in severe cases, seizures or kidney problems. If an overdose is suspected, seek medical advice immediately. Prompt medical intervention can help manage any adverse effects and ensure the patient's well-being. Timely treatment is crucial to minimize the impact of an overdose.

In the case of a missed dose of Cephazolin 500mg injection, it is important to administer the medication as soon as possible. If it is almost time for the next scheduled dose, skip the missed dose and continue with the regular dosing schedule. However, do not double the dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for guidance, as they may recommend adjusting the dosing schedule to ensure the best treatment outcome. It is crucial to maintain a consistent medication routine for effective treatment.

To administer Cephazolin 500mg injection, clean the injection site, insert the needle at a 90-degree angle, and inject the entire contents of the vial slowly, followed by a small amount of fluid to ensure complete delivery of the medication.

Here are the conditions and situations when Cephazolin 500mg injection should not be administered:

• Should not be used in patients with a known allergy to Cephazolin, penicillin, or other cephalosporin antibiotics.
• Contraindicated in individuals with a history of severe allergic reactions to any type of beta-lactam antibiotic.
• Not recommended for patients with severe kidney disease or those on dialysis, as dosage adjustments are necessary.
• Should not be used in patients with a history of severe gastrointestinal diseases, especially colitis.
• Contraindicated during breastfeeding, as Cephazolin may pass into breast milk and harm the nursing infant.
• Should not be used in patients with a history of severe liver impairment or active liver disease.
• Not suitable for individuals with a history of Stevens-Johnson syndrome or toxic epidermal necrolysis.
• Contraindicated in patients with a history of severe hypersensitivity reactions, such as anaphylaxis, to any medication.

The side effects of Cephazolin 500mg injection may include:

• Nausea and vomiting
• Diarrhea
• Skin rashes or itching
• Allergic reactions (hives, swelling, difficulty breathing)
• Pain or inflammation at the injection site
• Fever
• Headache
• Vaginal itching or discharge

Following are the precautions and warnings for Cefazolin 500mg Injection:

• Not suitable for patients with hypersensitivity to cephalosporins or penicillins, as cross-reactivity may occur.
• Caution is required in patients with renal impairment, as dosage adjustments may be necessary to prevent drug accumulation and toxicity.
• May cause Clostridium difficile-associated diarrhea; discontinue use if severe diarrhea occurs and seek medical attention.
• Use with caution in patients with a history of gastrointestinal diseases, particularly colitis, as it may exacerbate symptoms.
• Intravenous administration should be done under medical supervision to prevent injection site reactions such as pain, swelling, or thrombophlebitis.
• Prolonged use may lead to fungal or bacterial superinfections, including resistant organisms.
• Liver and kidney function should be monitored in patients receiving prolonged therapy.
• May interfere with certain laboratory tests, such as urine glucose tests, leading to false-positive results.
• Use during pregnancy and breastfeeding should be done only if the potential benefits outweigh the risks, as safety data is limited.
• Patients should report any signs of an allergic reaction, including rash, itching, swelling, or difficulty breathing, to their healthcare provider immediately.

Following are the drug interactions for Cephazolin 500mg injection:

• Probenecid can decrease the elimination of Cephazolin, increasing its blood levels and risk of side effects.
• Nephrotoxic drugs (e.g., aminoglycosides, colistin) may increase the risk of kidney damage when used with Cephazolin.
• Cephazolin may reduce the effectiveness of oral contraceptives, requiring additional contraceptive measures.
• Concurrent use with other antibiotics, such as Chloramphenicol, may lead to an antagonistic effect.
• Anticoagulants like warfarin may have their effects potentiated, requiring close monitoring of coagulation parameters.
• Cephazolin may decrease the effectiveness of live vaccines, such as measles or varicella vaccines.
• Neuromuscular blocking agents, like succinylcholine, may have their effects enhanced by Cephazolin, requiring close monitoring during anesthesia.

Following are the food interactions for Cephazolin 500mg injection:

• Alcohol intake should be avoided as it may increase the risk of side effects related to the liver and kidneys.
• Grapefruit and grapefruit juice are best avoided as they can affect the metabolism of Cephazolin, potentially leading to increased drug levels in the body.
• Avoid high-sodium foods as Cephazolin may contain sodium content, and excessive sodium intake can lead to fluid retention and elevated blood pressure.
• Limit caffeine consumption as it may increase the risk of side effects like nervousness, rapid heartbeat, and insomnia.
• Avoid foods rich in Vitamin K (leafy greens, broccoli) as Cephazolin can affect blood clotting, and Vitamin K can counteract this effect.
• There are no specific food restrictions, but maintaining a balanced diet is recommended for overall health.
• Always consult your healthcare provider for personalized advice regarding food and drug interactions.
• Ensure proper hydration and a healthy diet to support your overall well-being during the treatment period.

Cephazolin 500mg injection should be stored in a controlled environment, specifically at room temperature between 20-25°C (68-77°F). Protect the injection from light and moisture by keeping it in its original packaging until use. Do not freeze the medication, as it may affect its potency. Once the vial is opened, it should be used immediately, and any unused portion should be discarded properly. To dispose of the medication, do not throw it into the trash or pour it down the drain. Instead, follow local guidelines for pharmaceutical waste disposal or consult a healthcare professional for guidance on safe disposal practices. Ensure that the injection is kept out of the reach of children and pets to prevent accidental exposure.

Following are the quick tips for Cephazolin 500mg Injection:

• Administer the injection under medical supervision for safe and effective use.
• Ensure the injection is prepared and administered by trained medical personnel.
• Follow the prescribed dosage and duration as directed by your doctor.
• Cephazolin should be injected slowly over 3-5 minutes to minimize discomfort.
• Avoid rapid or bolus injections to prevent adverse effects.
• Do not use if the solution is discolored or contains particles.
• Report any signs of allergic reactions immediately to your healthcare provider.