Kemadrin (5mg) 100 Tablets

Procyclidine, a 5mg tablet, primarily acts as an anticholinergic agent. It exerts its effects by blocking the action of acetylcholine, a neurotransmitter, at specific receptor sites known as muscarinic receptors. This blockade occurs in various parts of the central nervous system, particularly in the extrapyramidal motor system. By inhibiting the action of acetylcholine, procyclidine helps to alleviate the excessive cholinergic activity that is often associated with conditions like Parkinson's disease. The drug's mechanism is focused on reducing the intensity of involuntary muscle movements, tremors, and stiffness, thereby improving the overall motor control and coordination in patients.

Anticholinergic

Tablet

The following are the uses of Procyclidine 5mg Tablet:

• Used for controlling Parkinson's disease symptoms like tremors, stiffness, and slow movement.
• Used to treat side effects of certain medications, reducing uncontrolled movements and muscle stiffness.
• Used for managing drug-induced Parkinsonism, restoring normal movement and coordination.
• Used to alleviate muscle stiffness and spasms, particularly in older adults.
• Used to treat a rare condition called dystonia, helping to relax muscles and reduce involuntary movements.
• Used for managing certain movement disorders, improving overall motor control and functionality.
• Used as a supportive medication to enhance the effects of other treatments for movement-related issues.

To be used as per doctor's instructions

In the case of an overdose of Procyclidine 5mg Tablets, it is important to recognize the potential symptoms, which may include severe dry mouth, blurred vision, confusion, and difficulty in passing urine. If an overdose is suspected, immediate medical assistance should be sought. Prompt treatment can help mitigate the risks associated with an overdose, including potential complications related to the central nervous system and the heart. The healthcare provider will determine the appropriate course of action to manage the overdose and provide necessary support.

In the case of a missed dose of Procyclidine 5mg Tablet, it is important to take the medication as soon as you remember. If it is almost time for your next scheduled dose, skip the missed one. It is generally recommended not to double the dose to make up for a missed one. However, if you miss several doses, consult your healthcare professional for advice on how to get back on track with your medication schedule. They will provide guidance tailored to your specific needs and ensure you resume the medication safely.

To take Procyclidine 5mg Tablet, swallow the tablet whole with a glass of water, as directed by your healthcare professional, typically two to three times a day, maintaining a consistent interval between doses.

Here are the conditions or situations when Procyclidine 5mg Tablet should not be used:

• Do not take if you have a known allergy to procyclidine or any other belladonna-like compounds.
• Contraindicated in patients with narrow-angle glaucoma.
• Not suitable for individuals with a blockage in the gut (gastrointestinal obstruction).
• Should not be used in patients with myasthenia gravis.
• Avoid if you have a condition called megacolon (a severe form of constipation).
• Not recommended for individuals with a history of seizures or epilepsy.
• Do not use if you have difficulty passing urine or an enlarged prostate.
• Contraindicated during pregnancy, especially in the first trimester, unless considered essential by a healthcare professional.

The side effects of Procyclidine 5mg Tablet may include:

• Dry mouth
• Blurred vision
• Dizziness
• Nausea and vomiting
• Constipation
• Difficulty urinating
• Skin rash
• Confusion, especially in elderly patients

Following are the precautions and warnings for Procyclidine 5mg Tablet:

• Do not use if you are allergic to procyclidine or any similar medications, and inform your doctor about any known allergies.
• This medication may cause drowsiness and blurred vision, so avoid driving or operating machinery until you know how it affects you.
• Patients with glaucoma, urinary retention, or myasthenia gravis should use with caution and under medical supervision.
• Alcohol consumption should be avoided as it may enhance the sedative effects of the medicine.
• Elderly individuals may be more sensitive to the side effects; thus, close monitoring is necessary.
• Procyclidine may cause dry mouth; regular dental hygiene is recommended to minimize dental issues.
• If you have a history of liver or kidney problems, discuss with your doctor as it may affect the dosage.

Following are the drug interactions for Procyclidine 5mg Tablet:

• Alcohol and other central nervous system (CNS) depressants can enhance the sedative effects of procyclidine, leading to increased drowsiness and impaired motor skills.
• Antimuscarinic drugs like atropine or other anticholinergics may have additive effects, potentially causing severe anticholinergic symptoms such as dry mouth, blurred vision, and urinary retention.
• Procyclidine may interact with medications that affect the metabolism of drugs by the liver, such as CYP450 enzyme inducers (e.g., rifampicin) or inhibitors (e.g., ketoconazole), altering its effectiveness.
• It may reduce the effectiveness of certain medications used to treat Parkinson's disease, such as levodopa, due to its anticholinergic properties.
• Use with other drugs that can cause QT prolongation, such as certain antiarrhythmic medications, may increase the risk of cardiac arrhythmias.
• Procyclidine can antagonize the effects of acetylcholinesterase inhibitors, potentially reducing their therapeutic benefits in conditions like Alzheimer's disease.
• The effects of certain medications used to treat gastrointestinal disorders, such as metoclopramide, may be diminished by procyclidine due to its anticholinergic properties.

Following are the food interactions to consider with Procyclidine 5mg Tablet:

• Alcohol should be consumed with caution as it may enhance the sedative effects of Procyclidine, leading to increased drowsiness and dizziness.
• Grapefruit and grapefruit juice should be avoided as they can inhibit the metabolism of Procyclidine, potentially resulting in higher drug levels in the body and an increased risk of side effects.
• Avoid consuming large amounts of dairy products, as they may decrease the absorption of Procyclidine due to their high calcium content.
• Spicy and fatty foods may cause stomach irritation and affect the absorption of Procyclidine, so it's best to consume them in moderation.
• Caffeine-rich beverages like coffee and energy drinks may increase the side effects of Procyclidine, such as nervousness and insomnia, and should be limited.
• Procyclidine should be taken with a full glass of water, and maintaining adequate hydration is essential to prevent potential side effects like dry mouth and constipation.
• Avoid eating heavy meals before taking Procyclidine, as it may slow down the absorption of the medication. Instead, opt for a light snack or meal.
• There are no specific food restrictions with Procyclidine, but it's advisable to maintain a balanced diet to support overall health.

Procyclidine 5mg Tablets should be stored in a secure and dry location, preferably in a medicine cabinet or a designated storage area. Keep the tablets in their original container, tightly sealed, to maintain their integrity and protect them from moisture and light. Avoid exposing the medication to direct sunlight, as it can degrade the active ingredients. It is crucial not to store the tablets in bathrooms or kitchens, as heat and humidity can affect their quality. Always check the expiration date regularly and dispose of any expired or unused tablets promptly. When disposing of the medication, do not flush it down the toilet or pour it into a sink; instead, follow local guidelines for pharmaceutical waste disposal or consult a pharmacist for safe disposal methods. Keep the tablets out of children's reach to prevent accidental consumption, ensuring a safe and responsible approach to medication management.

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Following are the quick tips for Procyclidine 5mg Tablet:

• Take the tablet as directed by your doctor, typically 3-4 times a day.
• Ensure you swallow the tablet whole with a full glass of water.
• Maintain a consistent schedule for taking the medication, preferably at evenly spaced intervals.
• Avoid abruptly stopping the medication; gradually reduce the dose as advised by your doctor.
• Inform your doctor if you have any medical conditions, especially glaucoma or prostate issues.
• Do not drive or operate machinery until you know how this medicine affects you.
• Store the tablets at room temperature, away from moisture and direct sunlight.