Ketoflex retard (200mg) 20 Tablets

Ketoprofen, a nonsteroidal anti-inflammatory drug (NSAID), exerts its mechanism of action primarily by inhibiting cyclooxygenase (COX) enzymes, specifically COX-1 and COX-2. These enzymes play a crucial role in the synthesis of prostaglandins, which are involved in mediating pain, inflammation, and fever. By blocking COX enzymes, ketoprofen reduces the production of prostaglandins, thereby alleviating pain and inflammation. This inhibition occurs at the site of inflammation, where ketoprofen interrupts the arachidonic acid cascade, leading to decreased formation of inflammatory mediators. Ketoprofen's ability to inhibit prostaglandin synthesis is responsible for its analgesic, anti-inflammatory, and antipyretic properties, making it effective in managing various conditions characterized by pain, inflammation, and fever.

Ketoprofen

Non-steroidal anti-inflammatory drug (NSAID).

Tablet

The following are the uses of Ketoprofen Tablet:

• Used for relieving pain and reducing inflammation caused by conditions like arthritis, muscle strains, and sprains.
• Used for treating acute pain and swelling after minor surgeries or dental procedures.
• Used for managing pain and stiffness associated with osteoarthritis.
• Used for reducing fever and inflammation in conditions such as severe menstrual cramps.
• Used for providing temporary relief from headache and migraine pain.
• Used for alleviating discomfort and inflammation in minor injuries.
• Used for controlling pain and inflammation in certain inflammatory conditions.

In the case of an overdose of Ketoprofen Tablets, individuals may experience symptoms such as nausea, vomiting, stomach pain, and in severe cases, gastrointestinal bleeding. It is important to recognize the signs of an overdose, which can include severe stomach pain, dizziness, and difficulty breathing. If an overdose is suspected, immediate medical assistance should be sought, and the individual should be monitored for any adverse effects, especially in the gastrointestinal system. Prompt action can help manage and mitigate the potential risks associated with Ketoprofen Tablet overdoses.

In the case of a missed dose of Ketoprofen Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to safely resume your medication regimen without compromising its effectiveness. It is essential to maintain a consistent dosing routine for optimal pain management.

To take Ketoprofen Tablets, swallow the tablet whole with a full glass of water, preferably with food or after meals, following the dosage instructions provided by your doctor or as directed on the prescription label, typically taken 3 to 4 times a day.

Here are the conditions or situations when Ketoprofen Tablet should not be used:

• Should not be taken by individuals who have a known allergy or hypersensitivity to Ketoprofen or other NSAIDs (Non-Steroidal Anti-Inflammatory Drugs).
• Contraindicated in patients with active peptic ulcers or gastrointestinal bleeding.
• Not recommended for individuals with a history of asthma or severe allergic reactions triggered by Aspirin or other NSAIDs.
• Should be avoided in patients with severe heart failure or heart disease.
• Do not use if you have recently undergone coronary artery bypass graft (CABG) surgery.
• Contraindicated in pregnant women, especially during the third trimester, due to potential harm to the fetus.
• Not suitable for breastfeeding mothers, as Ketoprofen may pass into breast milk and harm the nursing infant.
• Should not be used in patients with severe kidney disease or active kidney conditions.
• Avoid using Ketoprofen if you have bleeding disorders or are taking blood thinners.
• Not recommended for individuals with severe dehydration or low fluid volume.

The side effects of Ketoprofen Tablet may include:

• Stomach pain or discomfort
• Nausea and vomiting
• Diarrhea
• Constipation
• Dizziness or vertigo
• Drowsiness or fatigue
• Skin rash or itching
• Increased blood pressure

Following are the precautions and warnings for Ketoprofen Tablet:

• Not recommended for individuals with a known hypersensitivity or allergy to Ketoprofen or other NSAIDs (Non-Steroidal Anti-Inflammatory Drugs).
• Patients with a history of gastrointestinal bleeding, ulcers, or other gastrointestinal disorders should use with caution and under medical supervision.
• May increase the risk of cardiovascular events like heart attack or stroke, especially with long-term use. Regular monitoring is advised.
• Not suitable for individuals with severe heart failure or uncontrolled hypertension.
• Can cause renal impairment, particularly in patients with existing kidney problems. Regular monitoring of kidney function is necessary.
• Elderly patients may be more susceptible to side effects, and dosage adjustments might be required.
• Not recommended during pregnancy and breastfeeding unless clearly needed and under medical supervision.

Following are the drug interactions for Ketoprofen Tablet:

• Concomitant use with other non-steroidal anti-inflammatory drugs (NSAIDs) or aspirin may increase the risk of gastrointestinal bleeding and ulcers.
• Can reduce the effectiveness of angiotensin-converting enzyme (ACE) inhibitors and diuretics, leading to decreased blood pressure control.
• Ketoprofen may increase plasma concentrations of lithium, requiring close monitoring of lithium levels.
• Anticoagulants like warfarin may have their effects enhanced, increasing the risk of bleeding.
• Methotrexate toxicity can be increased when used with Ketoprofen, potentially affecting kidney function.
• When taken with corticosteroids, the risk of gastrointestinal bleeding and ulceration is elevated.
• May reduce the effectiveness of beta-blockers in controlling high blood pressure.

Following are the food interactions for Ketoprofen Tablet:

• Avoid excessive alcohol consumption while taking this medication, as it can increase the risk of stomach bleeding and liver damage.
• Grapefruit and grapefruit juice should be consumed with caution as they may affect the metabolism of Ketoprofen, potentially increasing its levels in the body and the risk of side effects.
• Dairy products like milk and cheese may interfere with Ketoprofen absorption, so it's advisable to separate their consumption by at least 1-2 hours.
• Foods high in vitamin K, such as spinach, broccoli, and kale, may reduce the blood-thinning effects of Ketoprofen, so maintaining a consistent diet is essential.
• Avoid high-sodium foods as Ketoprofen can cause sodium retention, and excessive sodium intake may increase blood pressure.
• Consuming fatty or greasy foods while taking Ketoprofen may increase the risk of gastrointestinal issues.
• Ketoprofen may cause fluid retention, so limiting foods high in salt and sugar is recommended to maintain healthy fluid balance.
• Always stay well-hydrated by drinking enough water, especially if you experience stomach irritation with Ketoprofen.

Ketoprofen Tablets should be stored in a secure and dry location, preferably at room temperature, away from direct sunlight, heat, and moisture. It is crucial to keep the tablets in their original container, tightly sealed, to maintain their integrity and prevent contamination. Do not transfer the medication to a different container as it may compromise its quality. Always inspect the tablets for any signs of damage or discoloration before use. When disposing of unused or expired Ketoprofen Tablets, do not throw them in the trash or flush them down the toilet. Instead, follow local guidelines for medication disposal or consult your pharmacist for environmentally safe disposal methods. Keep the medication out of children's reach to ensure their safety.

Following are the quick tips for Ketoprofen Tablet:

• Take the tablet with or after food to minimize stomach irritation.
• Swallow the tablet whole with a full glass of water, do not crush or chew.
• Avoid alcohol consumption as it may increase the risk of stomach bleeding.
• Inform your doctor if you have a history of kidney or liver disease before taking this medication.
• Do not take other NSAIDs or aspirin while using Ketoprofen without consulting your doctor.
• If you are pregnant or breastfeeding, consult your doctor about the benefits and risks.
• Store the tablets at room temperature, away from moisture and heat.