Ketogesic (100mg) 2ml, 5 Ampoule Injections

Ketoprofen injection, a non-steroidal anti-inflammatory drug (NSAID), exerts its analgesic, anti-inflammatory, and antipyretic effects through the inhibition of cyclooxygenase (COX) enzymes. By blocking COX-1 and COX-2, Ketoprofen reduces the formation of prostaglandins, which are key mediators of pain, inflammation, and fever. This inhibition decreases the production of inflammatory mediators, leading to reduced pain, inflammation, and swelling at the site of injury or inflammation. Ketoprofen's mechanism of action is particularly effective in managing acute and chronic conditions characterized by inflammation and pain.

Ketoprofen

Nonsteroidal anti-inflammatory drug (NSAID)

Injection

The following are the uses of Ketoprofen injection:

• Used for relieving severe pain, especially in post-operative and musculoskeletal conditions.
• Used for reducing inflammation and swelling in conditions like arthritis.
• Used for managing pain and inflammation in acute injuries.
• Used for treating severe migraine attacks.
• Used for alleviating pain and stiffness in certain rheumatic diseases.
• Used for providing rapid pain relief in cases of kidney stones.
• Used for managing pain and improving mobility in acute gout attacks.
• Used for short-term pain management in various medical procedures.

In the case of an overdose of Ketoprofen injection, symptoms may include severe gastrointestinal issues such as nausea, vomiting, and abdominal pain. Additionally, patients may experience central nervous system effects like headaches, dizziness, and confusion. In severe cases, an overdose can lead to respiratory depression, reduced blood pressure, and in rare instances, coma. It is crucial to seek medical assistance promptly if an overdose is suspected to prevent potential complications.

In the case of a missed dose of Ketoprofen injection, it is important to act promptly. If you realize you have missed a scheduled dose, administer it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. It is crucial to maintain a consistent dosing regimen for the medication to be effective and to minimize potential adverse reactions. Consult your healthcare provider if you frequently miss doses or have concerns about your treatment plan.

To administer Ketoprofen injection, clean the injection site with an alcohol swab, insert the needle at a 90-degree angle, and inject the prescribed dose slowly, ensuring the entire dose is delivered, following the instructions provided by your healthcare professional for the correct dosage and injection technique.

Following are the conditions when Ketoprofen injection should not be used:

• Should not be administered to individuals who have a known allergy or hypersensitivity to Ketoprofen, other NSAIDs (non-steroidal anti-inflammatory drugs), or any of the ingredients in the injection.
• Contraindicated in patients with active or suspected gastrointestinal bleeding, ulcers, or perforation.
• Not recommended for individuals with severe heart failure or heart disease.
• Should not be used in patients with severe kidney or liver impairment.
• Contraindicated in individuals who have recently undergone coronary artery bypass graft (CABG) surgery.
• Not suitable for patients with uncontrolled hypertension (high blood pressure).
• Should be avoided in patients with a history of asthma or allergic reactions triggered by aspirin or other NSAIDs.
• Not recommended for individuals with a history of bleeding disorders or those taking anticoagulant medications.
• Should not be used in patients with severe dehydration or low blood volume.

The side effects of Ketoprofen injection may include:

• Nausea and vomiting.
• Stomach pain or discomfort.
• Diarrhea or constipation.
• Dizziness or vertigo.
• Headache or migraine.
• Skin reactions such as rash, itching, or hives.
• Increased blood pressure.
• Drowsiness or fatigue.

Following are the precautions and warnings for Ketoprofen Injection:

• Ketoprofen should be used with caution in patients with a history of gastrointestinal disorders, such as peptic ulcers or bleeding, as it may increase the risk of gastrointestinal irritation, ulceration, or bleeding.
• It should be avoided in patients with known hypersensitivity to ketoprofen or other nonsteroidal anti-inflammatory drugs (NSAIDs), as this may lead to severe allergic reactions.
• Use with caution in patients with cardiovascular conditions, including heart failure, as NSAIDs can increase the risk of fluid retention, hypertension, and exacerbate heart failure.
• Ketoprofen may increase the risk of renal toxicity, especially in patients with pre-existing kidney disease or dehydration. Ensure adequate hydration before administration.
• Patients with liver disease or abnormal liver function tests should be monitored closely, as ketoprofen may worsen liver function.
• Avoid concurrent use with other NSAIDs, as this can increase the risk of adverse effects, including gastrointestinal bleeding and renal damage.
• The injection should be administered slowly and under the supervision of a healthcare provider to prevent adverse reactions, such as dizziness, headache, or hypotension.
• Use with caution in elderly patients, who may be more susceptible to the side effects of NSAIDs, including gastrointestinal bleeding, renal impairment, and cardiovascular issues.
• Monitor for signs of allergic reactions, such as skin rashes, itching, or swelling, especially during the first few doses.
• Ketoprofen should be avoided during the third trimester of pregnancy due to potential risks to the fetus. Consult a healthcare provider before use during pregnancy or breastfeeding.
• Ketoprofen may interact with certain medications, such as anticoagulants, antihypertensives, or other pain relievers, so close monitoring is necessary when used in combination.
• In case of overdose, seek immediate medical attention to prevent serious complications like respiratory depression, renal failure, or gastrointestinal bleeding.

Following are the drug interactions for Ketoprofen injection:

• May increase risk of bleeding when combined with anticoagulants like heparin or warfarin.
• NSAIDs such as ibuprofen or naproxen can enhance the adverse effects of Ketoprofen, including gastrointestinal bleeding and kidney damage.
• Lithium levels may be increased, leading to potential toxicity.
• When used with diuretics, especially loop diuretics, Ketoprofen may decrease diuretic and antihypertensive effects.
• Increased risk of nephrotoxicity when combined with nephrotoxic drugs like cyclosporine or tacrolimus.
• Can reduce the effectiveness of antihypertensive medications, including beta-blockers and ACE inhibitors.
• May compete with other highly protein-bound drugs, such as phenytoin, leading to increased free drug concentrations and potential toxicity.

Following are the food interactions to consider with Ketoprofen injection:

• Avoid excessive alcohol consumption during treatment, as it can increase the risk of gastrointestinal bleeding and liver toxicity.
• Grapefruit and grapefruit juice should be consumed with caution as they can interfere with the metabolism of Ketoprofen, potentially increasing its levels in the body and the risk of side effects.
• Fatty foods may delay the absorption of Ketoprofen, but this is generally not a significant concern.
• Avoid taking Ketoprofen with high-fat meals as it may increase the risk of gastrointestinal side effects.
• There is no specific food restriction, but maintaining a balanced diet is advisable to support overall health during treatment.
• Avoid herbal supplements, especially those affecting blood clotting, as they can interact with Ketoprofen's action.
• Consult a healthcare professional for personalized advice regarding dietary restrictions and potential interactions.

Ketoprofen injection should be stored in a controlled room temperature environment, typically between 20-25°C (68-77°F), in its original packaging to protect it from light and moisture. Ensure the injection is kept away from direct sunlight and heat sources like radiators or stoves, as temperature fluctuations can impact its potency. Check the expiration date regularly, and do not use the injection if it has expired. When it's time to dispose of the injection, do not pour it down the sink or flush it; instead, follow local guidelines for the safe disposal of medical waste or consult a healthcare professional for guidance on proper disposal methods. Keep the injection securely stored and out of the reach of children to prevent accidental exposure.

Following are the quick tips for Ketoprofen injection:

• Ensure the injection is administered by a trained healthcare professional.
• Inform your doctor about any allergies or medical conditions before injection.
• Follow the prescribed dosage and treatment duration for best results.
• Avoid alcohol consumption as it may increase the risk of stomach bleeding.
• Ketoprofen may cause dizziness; avoid driving or operating machinery until you know how it affects you.
• Report any unusual bleeding, bruising, or black/tarry stools to your doctor promptly.
• Store the injection as directed and protect it from light and moisture.