Ketomed (100mg/2ml) 5 Ampoule Injections

Ketotifen injection is a medication primarily used for its anti-allergic and mast cell stabilizing properties. Its mechanism of action involves blocking H1-receptors, thereby inhibiting the release of histamine and other inflammatory mediators from mast cells and basophils. By preventing the activation of these cells, Ketotifen reduces the severity of allergic reactions and provides relief from symptoms such as itching, hives, and nasal congestion. Additionally, Ketotifen also exhibits anti-inflammatory effects by inhibiting the release of leukotrienes and other inflammatory substances, contributing to its overall therapeutic action in managing allergic conditions.

Ketotifen

Ketotifen is an antihistamine.

Injection

The following are the uses of Ketotifen injection:

• Used for preventing and treating severe allergic reactions, especially anaphylaxis.
• Used for relieving allergic symptoms like severe itching, hives, and swelling.
• Used for managing chronic urticaria and other skin conditions with severe itching.
• Used for stabilizing mast cells and reducing the release of inflammatory substances.
• Used for preventing exercise-induced anaphylaxis and asthma symptoms.
• Used for short-term treatment of asthma attacks when rapid relief is needed.
• Used for providing quick relief in emergency situations related to allergies.

In the case of an overdose of Ketotifen injection, several symptoms may occur. These include drowsiness, agitation, confusion, and respiratory depression. Immediate medical attention is required, and the patient should be monitored for vital signs and potential complications. Treatment involves supportive care, with a focus on maintaining respiratory function and managing any cardiovascular effects. Prompt action and medical intervention are vital to ensure the best possible outcome.

In the case of a missed dose of Ketotifen injection, it is important to administer the medication as soon as you remember. However, if it is almost time for the next scheduled dose, skip the missed dose and continue with the regular dosing schedule. Do not double the dose to make up for a missed one. If you miss several doses, contact your healthcare professional for advice, as they may recommend adjusting the dosage or provide specific guidance based on your medical condition and treatment plan.

To administer the Ketotifen injection, clean the injection site with an alcohol swab, insert the needle at a 90-degree angle, and inject the prescribed dose subcutaneously or intramuscularly as directed by your healthcare provider, ensuring proper needle disposal afterward.

Following are the conditions/situations when Ketotifen injection should not be administered:

• Allergic reaction • Must not be used in individuals with a known or suspected allergy or hypersensitivity to Ketotifen or any of its excipients.
• Asthma Attack • Not suitable during an acute asthma attack or severe asthma episode. It is meant for long-term asthma control and not as a rescue medication.
• Liver Impairment • Contraindicated in patients with severe liver impairment as it can lead to increased drug toxicity.
• Pregnancy and Breastfeeding • Should be avoided during pregnancy, especially in the first trimester, unless the potential benefits outweigh the risks. It is also not recommended while breastfeeding as it may pass into breast milk.
• Children under 3 years old • Ketotifen injection is not recommended for very young children due to potential risks and limited data on safety and efficacy in this age group.
• Patients with Narrow-Angle Glaucoma • It should be used with caution and under medical supervision in patients with a history of narrow-angle glaucoma.
• Immunocompromised Patients • Use with caution in individuals with compromised immune systems, as Ketotifen can suppress immune responses.

The side effects of Ketotifen injection may include:

• Fatigue and drowsiness
• Dizziness
• Dry mouth
• Upset stomach
• Skin rash or itching
• Increased appetite and weight gain
• Difficulty in concentration

Following are the precautions and warnings for Ketotifen injection:

• Not recommended for individuals with a known allergy to Ketotifen or any of its components.
• Patients with a history of liver or kidney disease should use with caution, as these conditions may affect the metabolism and elimination of the drug.
• Ketotifen may cause drowsiness and dizziness, so patients should avoid driving, operating heavy machinery, or engaging in activities that require mental alertness until they know how the medication affects them.
• Elderly patients may be more sensitive to the side effects, especially drowsiness and dizziness.
• This medication should be used with caution in children, and the dosage should be carefully determined by a healthcare professional.
• Pregnant or breastfeeding women should consult their doctor before using Ketotifen, as its safety during pregnancy and breastfeeding is not fully established.
• If you have a scheduled surgery, inform your doctor about Ketotifen usage, as it may affect certain diagnostic procedures.

Following are the drug interactions for Ketotifen injection:

• Ketotifen can enhance the sedative effects of central nervous system depressants like benzodiazepines, alcohol, and opioids, potentially leading to increased drowsiness and impaired breathing.
• The injection may interact with certain antibiotics, such as erythromycin and clarithromycin, which can result in elevated levels of Ketotifen in the body.
• Antifungal medications like ketoconazole and itraconazole can also increase Ketotifen levels, potentially leading to enhanced side effects.
• Caution is advised when using Ketotifen with beta-blockers, as it may mask symptoms of hypoglycemia and reduce the effectiveness of beta-blockers in treating cardiovascular conditions.
• The injection may reduce the effectiveness of certain vaccines, so it is recommended to separate vaccination and Ketotifen administration by at least 48 hours.
• Ketotifen can interact with other antihistamines, leading to increased drowsiness and impaired alertness.
• It may also affect the metabolism of drugs processed by the liver, such as certain anticonvulsants and antidepressants, potentially requiring dosage adjustments.

Following are the food interactions to be aware of when using Ketotifen injection:

• Ketotifen may interact with alcohol, leading to increased drowsiness and dizziness. Avoid or limit alcohol consumption during treatment.
• Grapefruit and grapefruit juice should be consumed with caution as they can affect the metabolism of the drug, potentially increasing its levels in the body.
• High-fat meals can slow down the absorption of Ketotifen, delaying its onset of action. Consider taking the medication on an empty stomach or with a light meal.
• Caffeine-rich foods and beverages might enhance the stimulant effects of Ketotifen, potentially causing restlessness and sleep disturbances.
• Avoid consuming excessive amounts of vitamin C-rich foods, as high doses of vitamin C may interfere with the antihistamine action of Ketotifen.
• Spicy foods should be approached with caution, as they can potentially trigger or exacerbate allergic reactions, reducing the effectiveness of the medication.
• Ketotifen may interact with certain herbal supplements, especially those with sedative properties, so consult your healthcare provider before taking any herbal remedies.
• Always follow the advice of your healthcare professional regarding dietary restrictions or recommendations specific to your medical condition.

Ketotifen injection should be stored in a controlled environment, preferably between 68°F and 77°F (20°C and 25°C), with brief excursions permitted between 59°F and 86°F (15°C and 30°C). Protect it from light and excessive heat. Once the vial is opened, it should be used immediately, and any unused portion should be discarded. Proper disposal of the injection is crucial; do not reuse needles, syringes, or other injection materials. Utilize a puncture-resistant container for disposal, and follow local regulations or guidelines for proper disposal methods. Keep the medication out of the reach of children and pets to prevent accidental exposure.

Following are the quick tips for Ketotifen injection:

• Consult your doctor for the correct dosage and administration instructions specific to your condition.
• Ensure the injection is administered by a trained healthcare professional.
• Inform your doctor about any allergies or medical conditions before receiving the injection.
• Avoid missing doses; maintain consistency for better control of your symptoms.
• Do not inject into skin areas with redness, pain, or swelling; inform your doctor if you notice these issues.
• Store the injection as directed on the packaging, usually at room temperature, away from light.
• Dispose of used needles and syringes safely in designated sharps containers.