Kinz (20mg/ml) 5 Ampoule Injections

Nalbuphine, a synthetic opioid, exerts its mechanism of action by acting as a mixed agonist-antagonist at opioid receptors. It binds to mu-opioid receptors, acting as a partial agonist, which provides analgesic effects. Simultaneously, it acts as an antagonist at the kappa-opioid receptors, reducing some of the undesirable side effects associated with full opioid agonists. This dual action contributes to its pain-relieving properties while minimizing the potential for respiratory depression and other opioid-related adverse reactions. The partial agonism at the mu-receptors allows for effective pain management, while the antagonism at kappa-receptors may contribute to a more favorable side effect profile compared to some other opioids.

opioid analgesic.

injection

The following are the uses of Nalbuphine 20mg injection:

• Used for effective pain relief during labor and delivery, providing comfort to the mother.
• Used for managing postoperative pain, ensuring a smoother recovery process.
• Used to alleviate moderate to severe pain, offering quick and efficient relief.
• Used in the treatment of acute trauma pain, aiding in immediate management.
• Used for pain control in patients who cannot tolerate other opioids, providing an alternative option.
• Used to relieve pain caused by kidney stones, offering much-needed comfort.
• Used for short-term pain management, allowing for targeted and immediate treatment.
• Used as an adjunct to anesthesia, enhancing pain control during surgical procedures.

Follow these dosage instructions:

• Adult Dosage

Initial dosage, 10 mg IV, IM, or subcutaneous every 3 to 6 hours as needed. Your doctor will determine the length of the treatment and may adjust the dose after some time.

• Child Dosage

The dosage for the child is strictly recommended by the doctor.

In the case of an overdose of Nalbuphine 20mg injection, several symptoms may manifest. These can include respiratory depression, where breathing becomes slow and shallow, leading to potential oxygen deprivation. Additionally, extreme drowsiness, confusion, and a significant drop in blood pressure may occur. It is imperative to promptly seek medical assistance if an overdose is suspected, as these symptoms can be life-threatening and may require urgent intervention and treatment.

In the case of a missed dose of Nalbuphine 20mg injection, it is important to administer the medication as soon as you remember. However, if it is almost time for the next scheduled dose, it is recommended to skip the missed dose and continue with the regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to safely adjust your medication schedule. It is crucial to maintain a consistent dosing routine for the best therapeutic outcomes.

To administer Nalbuphine 20mg injection, clean the injection site with an alcohol swab, insert the needle at a 90-degree angle, and slowly inject the medication into the muscle, ensuring the entire dose is delivered as prescribed by your healthcare provider.

Here are the circumstances when Nalbuphine 20mg injection should not be administered:

• Not recommended for patients with known hypersensitivity or allergy to nalbuphine or any of its excipients.
• Contraindicated in patients with severe respiratory depression or asthma, as it may worsen breathing.
• Should not be used in patients with acute abdominal conditions or severe gastrointestinal issues.
• Not suitable for individuals with head injuries, increased intracranial pressure, or brain tumors.
• Contraindicated during and immediately before labor, as it may affect the baby's respiratory function.
• Should be avoided in patients with severe liver impairment or cirrhosis.
• Not recommended for patients with severe kidney disease or those on dialysis.
• Should not be used in patients with a history of seizures or conditions that lower the seizure threshold.
• Contraindicated in patients with acute alcohol intoxication.
• Not suitable for individuals with a history of drug abuse or addiction.

The side effects of Nalbuphine 20mg injection may include:

• Nausea and vomiting
• Dizziness or lightheadedness
• Sweating
• Itching or hives
• Skin redness or rash
• Slowed breathing rate
• Confusion or disorientation
• Constipation

Following are the precautions and warnings for Nalbuphine 20mg Injection:

• Nalbuphine should not be used in patients with a known allergy to nalbuphine, other opioid analgesics, or any of the components of the injection.
• Use with caution in patients with a history of respiratory disorders, including asthma, as nalbuphine may cause respiratory depression or worsen existing conditions.
• Nalbuphine should be administered cautiously to patients with liver or kidney disease, as the drug is metabolized in the liver and excreted by the kidneys.
• The injection may cause sedation, dizziness, or confusion, so caution should be exercised when operating heavy machinery or driving until its effects are fully understood.
• Nalbuphine is not recommended for use in patients with head injury, intracranial pressure increase, or impaired consciousness due to the risk of masking symptoms or increasing intracranial pressure.
• Caution should be exercised when administering nalbuphine to elderly patients, as they may be more sensitive to the drug's side effects, particularly respiratory depression and sedation.
• Nalbuphine may cause hypotension; monitor blood pressure closely, especially during the initiation of treatment or when used with other antihypertensive medications.
• Nalbuphine should be used with care in patients who are opioid-naive or those with a history of drug or alcohol abuse, as there is a potential for misuse or addiction.
• The injection can cause withdrawal symptoms if administered to patients who are physically dependent on opioids.
• Nalbuphine should not be used during pregnancy unless absolutely necessary, as its safety during pregnancy has not been established. It may cause withdrawal symptoms or respiratory depression in the newborn if administered close to delivery.
• Use with caution in breastfeeding women as nalbuphine may pass into breast milk and could affect the nursing infant.
• Nalbuphine may interact with other central nervous system depressants, such as alcohol, benzodiazepines, and other opioids, increasing the risk of severe sedation, respiratory depression, or overdose.
• Nalbuphine should be administered by a healthcare professional, and its effects should be monitored to avoid adverse reactions, especially respiratory depression.
• In case of overdose, immediate medical intervention is necessary, as nalbuphine may cause respiratory depression, sedation, or hypotension.

Following are the drug interactions for Nalbuphine 20mg injection:

• It may interact with central nervous system (CNS) depressants like benzodiazepines, barbiturates, or alcohol, leading to enhanced respiratory depression and sedation.
• Monoamine oxidase inhibitors (MAOIs) should be avoided within 14 days of using Nalbuphine, as it may cause serotonin syndrome or severe CNS depression.
• Concomitant use with other opioids can result in increased respiratory depression and sedation.
• Antihypertensive medications' effects may be reduced due to Nalbuphine's ability to release histamine, causing vasodilation.
• Nalbuphine may enhance the anticoagulant effect of warfarin, requiring close monitoring of prothrombin time.
• Its use with anticholinergics may lead to increased risk of urinary retention and constipation.
• Drugs that induce CYP450 enzymes can reduce Nalbuphine's efficacy by increasing its metabolism.

Following are the food interactions to consider with Nalbuphine 20mg injection:

• Alcohol consumption should be avoided as it can increase the sedative effects of Nalbuphine, leading to enhanced drowsiness and dizziness.
• Grapefruit and its juice should be consumed cautiously as they may interfere with the metabolism of Nalbuphine, potentially altering its effectiveness.
• Fatty foods may slightly delay the absorption of Nalbuphine, but this effect is generally not clinically significant.
• Avoid caffeine-rich beverages as they may counteract the analgesic effects of Nalbuphine, potentially requiring higher doses for pain relief.
• Spicy foods are not recommended immediately after the injection as they can irritate the injection site and cause discomfort.
• Maintaining a balanced diet is essential to support overall health and well-being during the use of Nalbuphine.
• Always follow the advice of your healthcare provider regarding dietary restrictions or recommendations specific to your condition.
• Proper hydration is crucial, especially if experiencing nausea or vomiting as side effects of the medication.

Nalbuphine 20mg injection should be stored properly to maintain its effectiveness and safety. Store it in a controlled room temperature environment, typically between 20°C and 25°C (68°F to 77°F), away from excessive heat, direct sunlight, and moisture. Keep the injection in its original packaging, ensuring the container is tightly sealed to prevent contamination. It's crucial not to freeze the medication as it may affect its potency. Always check the expiration date, and do not use the injection if it's expired. For disposal, do not pour it down the drain or flush it; instead, follow local guidelines or consult a healthcare professional for safe disposal methods to protect the environment and prevent misuse. Keep this medication out of the sight and reach of children.

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Following are the quick tips for Nalbuphine 20mg Injection:

• Ensure you receive this injection under medical supervision for pain management.
• Inform your doctor about any allergies or medical conditions before administration.
• Do not drive or operate heavy machinery if the injection causes dizziness.
• Avoid alcohol consumption as it may intensify side effects.
• Report any unusual symptoms or severe side effects to your healthcare provider immediately.
• Store the injection as directed by the pharmacist, away from direct sunlight and moisture.
• Do not reuse or share needles to prevent infection and ensure safe administration.