Klevra (500mg/5ml) 60ml Solution

Levetiracetam's mechanism of action is primarily believed to involve binding to synaptic vesicle protein 2A (SV2A) in the brain. This protein is present in the membranes of synaptic vesicles, which store and release neurotransmitters. By binding to SV2A, Levetiracetam is thought to modulate the release of excitatory neurotransmitters, particularly glutamate. It reduces the excessive release of glutamate, which is associated with epileptic seizures. This action helps stabilize neuronal hyperexcitability, thereby preventing the spread of seizure activity. Levetiracetam's selective binding to SV2A is considered to be responsible for its anticonvulsant effects, although the exact details of how this binding leads to seizure control are still being studied.

Levetiracetam 500mg

Anticonvulsant

Solution

The following are the uses of Levetiracetam 500mg Solution:

• Used for treating partial-onset seizures in adults and children with epilepsy.
• Used to manage seizures associated with Lennox-Gastaut Syndrome.
• Used to prevent seizures during and after brain surgery.
• Used as an add-on therapy for patients with refractory partial seizures.
• Used to provide seizure control when other medications are ineffective.
• Used to reduce seizure frequency and improve overall seizure control.
• Used to support patients in achieving better seizure management and quality of life.

In the case of an overdose of Levetiracetam 500mg Solution, it is important to seek medical assistance promptly. Overdosing on this medication can lead to symptoms such as drowsiness, agitation, weakness, and in severe cases, respiratory depression or seizures. Quick action is required, including contacting poison control or emergency services, as they can provide guidance and ensure appropriate treatment to manage the overdose effectively.

In the case of a missed dose of Levetiracetam 500mg Solution, it is important to take the medication as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for advice, as they may need to adjust your dosage or provide further instructions to ensure you receive the correct amount of medication.

To administer Levetiracetam 500mg Solution, use the provided oral syringe to measure the prescribed dose, and then administer the solution directly into your mouth or mix it with a small amount of water or juice before drinking it.

Here are the conditions or situations when Levetiracetam 500mg Solution should not be taken:

• Allergy Should not be used if the patient is allergic to Levetiracetam or any of the excipients in the solution.
• Liver disease Not recommended for patients with severe liver impairment or active liver disease.
• Renal impairment Should be used with caution in patients with severe renal impairment and may need a dose adjustment.
• History of depression or psychiatric disorders Use with caution as it may cause or worsen depression, suicidal thoughts, or other mental health issues.
• Certain medical conditions Not suitable for patients with a history of respiratory or lung diseases, blood disorders, or severe muscle weakness.
• Pregnancy and breastfeeding It is contraindicated in women who are pregnant or planning to become pregnant, and it may pass into breast milk, so caution is advised for breastfeeding mothers.

The side effects of Levetiracetam 500mg Solution may include:

• Dizziness or lack of coordination
• Fatigue and weakness
• Nausea and vomiting
• Irritability and aggression
• Memory problems and confusion
• Sleep disturbances, including insomnia or excessive sleepiness
• Skin rashes and itching
• Decreased appetite and weight loss

Following are the precautions and warnings for Levetiracetam 500mg Solution:

• Do not use if you are allergic to Levetiracetam or any of its ingredients.
• Patients with kidney problems should exercise caution and consult a healthcare professional, as dosage adjustments may be necessary.
• This medication may cause dizziness or drowsiness; avoid driving or operating heavy machinery until you know how it affects you.
• Alcohol consumption should be avoided as it may intensify the sedative effects of the medication.
• Inform your doctor if you have a history of respiratory or liver problems before taking this medication.
• Elderly patients may be more sensitive to the side effects; regular monitoring is recommended.
• If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before using this medication.
• Store the medication at room temperature, away from direct sunlight and moisture.

Following are the drug interactions for Levetiracetam 500mg Solution:

• May reduce the effectiveness of hormonal contraceptives, requiring additional contraceptive methods.
• Can decrease the efficacy of primidone and phenytoin, requiring monitoring and dose adjustments.
• Concomitant use with other CNS depressants (e.g., opioids, benzodiazepines) may enhance sedation and respiratory depression.
• Levetiracetam can lower blood concentrations of ethosuximide, requiring monitoring and potential dosage adjustments.
• May increase plasma concentrations of digoxin, necessitating therapeutic drug monitoring.
• Theophylline levels may be reduced when used with Levetiracetam, requiring close observation and dosage adjustments.
• Potential interaction with warfarin, requiring regular monitoring of INR and potential warfarin dose adjustments.

Following are the food interactions for Levetiracetam 500mg Solution:

• Levetiracetam can be taken with or without food, but maintaining a consistent routine is advisable.
• Avoid alcohol consumption while taking this medication as it may increase the risk of side effects and affect the central nervous system.
• Grapefruit and grapefruit juice should be consumed with caution as they can potentially interact with Levetiracetam, altering its effectiveness.
• Do not mix the medication with other liquids unless instructed by a healthcare professional.
• There is no specific food restriction, but a balanced diet is recommended to maintain overall health.
• Avoid excessive caffeine intake as it may interfere with the medication's effects on the central nervous system.
• Always follow the dosage instructions provided by your healthcare provider for optimal results.

Levetiracetam 500mg Solution should be stored in a secure and controlled environment, specifically in a cool and dry place, ideally at room temperature, ensuring it remains protected from direct sunlight and moisture. Keep the solution tightly sealed within its original container to maintain its integrity and prevent contamination. Avoid storing it in bathrooms or near heat sources, as temperature fluctuations can impact its effectiveness. Regularly check the expiration date, and when disposing of any unused or expired solution, do not flush it down the toilet or drain; instead, consult a pharmacist or healthcare professional for appropriate disposal methods to ensure environmental safety. Lastly, maintain vigilance by keeping the medication out of children's reach to prevent accidental ingestion.

Following are the quick tips for Levetiracetam 500mg Solution:

• Always take the solution as directed by your doctor; do not alter the dosage without medical advice.
• Measure the dose accurately using the provided measuring device.
• Ensure you understand the frequency of your doses and whether it should be taken with or without food.
• If you experience difficulty swallowing, you can mix the solution with a small amount of liquid or soft food.
• Store the medication at room temperature, away from direct sunlight and moisture.
• Do not share your medication with others, even if they have similar symptoms.
• Regularly monitor your health and inform your doctor of any changes or side effects.