Kofcare 200ml Syrup

Aminophylline, the active ingredient in Aminophylline Syrup/Suspension, primarily works by relaxing the smooth muscles in the airways and improving respiratory function. It is a combination of theophylline and ethylenediamine, with theophylline being the main therapeutic agent. Theophylline belongs to the methylxanthine class of drugs and acts as a non-selective phosphodiesterase inhibitor. This inhibition leads to an increase in intracellular cyclic adenosine monophosphate (cAMP) levels, which, in turn, relaxes bronchial smooth muscles, reduces airway resistance, and improves airflow to the lungs. Additionally, aminophylline may have mild anti-inflammatory effects on the airways and enhance the function of respiratory muscles, further contributing to its bronchodilatory action.

Aminophylline

Bronchodilator, xanthine derivative.

Suspension

The following are the uses of Aminophylline Syrup/Suspension:

• Used for opening up the airways and making breathing easier in conditions like asthma and chronic obstructive pulmonary disease (COPD).
• Used for relaxing the muscles in the airways to prevent asthma attacks.
• Used for treating exercise-induced asthma when taken before physical activity.
• Used for reducing inflammation in the lungs, helping to control asthma symptoms.
• Used for relieving symptoms of shortness of breath, wheezing, and chest tightness.
• Used for improving lung function and overall respiratory health.
• Used for providing quick relief during acute asthma episodes.

In the case of an overdose of Aminophylline Syrup/Suspension, symptoms may include nausea, vomiting, restlessness, and rapid heart rate. Seizures, irregular heart rhythms, and even cardiac arrest can occur in severe cases. Prompt medical attention is necessary, and emergency treatment may involve gastric lavage, activated charcoal, and supportive care to manage symptoms and stabilize the patient's condition. Medical professionals should be contacted immediately for guidance and treatment.

In the case of a missed dose of Aminophylline Syrup/Suspension, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss several doses, contact your healthcare provider for guidance on how to safely resume your medication regimen.

To administer Aminophylline Syrup/Suspension, shake the bottle well, measure the prescribed dose with an oral syringe or measuring cup, and take it by mouth, following the instructions provided by your healthcare professional, which may include taking it with or without food as directed.

Following are the conditions/situations when Aminophylline Syrup/Suspension should not be used:

• Should not be used in individuals with a known allergy to Aminophylline or other similar xanthine derivatives (such as theophylline or caffeine).
• Contraindicated in patients with a history of seizures or epilepsy, as it may lower the seizure threshold.
• Not recommended for individuals with stomach ulcers or gastrointestinal bleeding.
• Should not be used in patients with severe heart conditions, such as recent heart attack or unstable angina.
• Contraindicated in individuals with severe high blood pressure (hypertension) that is not well controlled.
• Should not be given to patients with an overactive thyroid (hyperthyroidism).
• Not suitable for individuals with liver disease or severe liver impairment.
• Contraindicated in patients with severe kidney disease or kidney failure.
• Should be avoided in patients with glaucoma, as it may increase eye pressure.
• Not recommended for individuals with a history of porphyria, a rare metabolic disorder.

The side effects of Aminophylline Syrup/Suspension may include:

• Nausea and vomiting
• Stomach pain or discomfort
• Headache
• Dizziness or lightheadedness
• Rapid or irregular heartbeat (palpitations)
• Nervousness or restlessness
• Insomnia
• Mild skin rash or itching

Following are the precautions and warnings for Aminophylline Syrup/Suspension:

• This medication should be used with caution in patients with heart disease, liver disease, or seizure disorders, as it may worsen these conditions.
• Regular monitoring of theophylline levels in the blood is essential to ensure the medication is within therapeutic range and to prevent toxicity.
• Aminophylline can cause an increase in heart rate and blood pressure, so patients with hypertension or cardiovascular issues should be closely monitored.
• Patients should be advised to avoid alcohol consumption as it can increase the risk of side effects.
• Elderly individuals may be more sensitive to the effects of this medication and should be closely monitored for adverse reactions.
• Do not use in patients with known hypersensitivity or allergy to aminophylline or other xanthine derivatives.
• Patients should be advised to seek immediate medical attention if they experience severe side effects such as irregular heartbeat, seizures, or difficulty breathing.

Following are the drug interactions for Aminophylline Syrup/Suspension:

• Aminophylline may decrease the effectiveness of beta-blockers, such as propranolol, as it can block their effects on the heart.
• It can increase the risk of side effects when used with other xanthine derivatives like theophylline or caffeine.
• Concomitant use with corticosteroids may increase the risk of seizures.
• Aminophylline can prolong the effects of certain antibiotics, such as erythromycin and clarithromycin, leading to increased side effects.
• Antacids containing aluminum or magnesium can reduce the absorption of Aminophylline, decreasing its effectiveness.
• The drug's effects may be enhanced by cimetidine, leading to increased side effects and toxicity.
• Linezolid, a MAO inhibitor, can increase the risk of serious side effects when used with Aminophylline.

Following are the food interactions for Aminophylline Syrup/Suspension:

• Avoid excessive caffeine intake from coffee, tea, energy drinks, or chocolate as it may enhance the stimulant effects of Aminophylline, leading to increased heart rate, anxiety, and sleep disturbances.
• Alcohol consumption should be minimized as it can increase the risk of side effects, particularly in the central nervous system, causing dizziness, headaches, and impaired coordination.
• Grapefruit and grapefruit juice should be consumed with caution as they may alter the metabolism of Aminophylline, potentially leading to increased drug levels and side effects.
• Dairy products like milk and cheese may interfere with the absorption of Aminophylline, reducing its effectiveness. It is advisable to separate dairy intake from medication by a few hours.
• High-fat meals can delay the absorption of Aminophylline, potentially affecting its onset of action. It is recommended to take the medication on an empty stomach or with a light meal.
• Avoid excessive consumption of foods rich in vitamin C, such as citrus fruits and supplements, as they may interfere with the therapeutic effects of Aminophylline.
• Maintain a balanced diet and ensure adequate hydration to support overall health and the medication's effectiveness.
• Always consult your healthcare provider or pharmacist for specific dietary recommendations and potential interactions based on your health condition.

Aminophylline Syrup/Suspension requires careful storage and disposal to maintain its effectiveness and ensure safety. Store the medication in a cool, dry area at room temperature, ensuring protection from direct sunlight and moisture. Keep the bottle tightly sealed to prevent contamination. Avoid storage in bathrooms or near heat sources like stoves or radiators, as temperature fluctuations can impact the medicine's quality. Always check the expiration date, and when disposing of unused or expired syrup, do not flush or pour it down the drain. Consult a pharmacist or healthcare professional for appropriate disposal methods. Keep the medication away from children to prevent accidental consumption.

Following are the quick tips for Aminophylline Syrup/Suspension:

• Consult your doctor for the right dosage and duration based on your medical condition.
• Shake the bottle vigorously before each use to ensure uniform mixing.
• Administer the syrup with a precise measuring device to ensure accurate dosing.
• Avoid missing doses to maintain consistent therapeutic levels in the body.
• Store the syrup at room temperature, away from direct sunlight and moisture.
• Discard any unused or expired medication as per your pharmacist's instructions.
• Inform your doctor about all medications you're taking to prevent potential drug interactions.