KOLFER INJ (VITAMIN D )

Cholecalciferol 4,000 IU injection acts by binding to the vitamin D receptor (VDR) in various target tissues. Once bound to the VDR, cholecalciferol undergoes metabolic activation through a series of hydroxylations in the liver and kidneys. This activation process converts cholecalciferol into its active form, calcitriol. Calcitriol then regulates calcium and phosphate metabolism by increasing intestinal absorption of calcium and phosphate, promoting renal reabsorption of calcium, and mobilizing calcium and phosphate from bone when needed. This mechanism helps maintain normal serum calcium and phosphate levels, which are essential for proper bone mineralization, muscle function, and overall physiological processes.

Cholecalciferol 4,000iu

Vitamin D3 analog

Injection

The following are the uses of Cholecalciferol 4,000iu injection:

• Used for treating and preventing Vitamin D deficiency, ensuring healthy bones and muscles.
• Used to manage conditions like rickets and osteomalacia, where Vitamin D levels are critically low.
• Used for individuals with limited sun exposure, such as the elderly or homebound.
• Used in patients with conditions like cystic fibrosis or malabsorption syndromes.
• Used post-surgery for faster recovery, especially in orthopedic procedures.
• Used to support immune function and reduce the risk of respiratory infections.
• Used in conjunction with calcium supplements to enhance their absorption.

In the case of an overdose of Cholecalciferol 4,000 IU injection, symptoms may include nausea, vomiting, weakness, and in severe cases, kidney damage and abnormal heart rhythms. The effects can be severe, particularly in children or individuals with underlying health conditions. It is crucial to seek medical assistance promptly if an overdose is suspected. Treatment involves managing symptoms and providing supportive care to minimize the potential long-term health consequences.

In the case of a missed dose of Cholecalciferol 4,000 IU injection, it is generally recommended to administer the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, it is best to skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare professional for guidance on how to proceed and ensure you stay on track with your treatment plan.

To administer Cholecalciferol 4,000 IU injection, clean the injection site with an alcohol swab, insert the needle at a 90-degree angle, and slowly inject the entire contents of the vial subcutaneously, ensuring the full dose is delivered.

Following are the conditions/situations when Cholecalciferol 4,000 IU injection should be avoided:

• Allergy Should not be used in individuals with a known or suspected allergy to Cholecalciferol, vitamin D compounds, or any of the injection's components.
• Hypervitaminosis D Contraindicated in patients with elevated vitamin D levels or conditions associated with hypervitaminosis D.
• Hypercalcemia Not recommended for individuals with high blood calcium levels or conditions causing hypercalcemia.
• Kidney stones Should be avoided in patients with a history of kidney stones or conditions that increase the risk of calcium-containing kidney stones.
• Sarcoidosis Contraindicated in untreated or uncontrolled sarcoidosis due to the risk of hypercalcemia.
• Granulomatous diseases Not suitable for patients with other granulomatous diseases, as it may lead to elevated calcium levels.
• Heart conditions Should be used with caution in individuals with heart problems, especially those with impaired cardiac function.
• Renal impairment Avoid use in patients with severe kidney disease or those on dialysis.
• Infants and young children Cholecalciferol injection is not recommended for infants and young children due to the risk of overdose and the availability of safer oral forms.

The side effects of Cholecalciferol 4,000 IU injection may include:

• Nausea and vomiting
• Weakness or fatigue
• Loss of appetite
• Dry mouth
• Metallic taste in the mouth
• Muscle or joint pain
• Increased thirst or urination
• Constipation or diarrhea

Following are the precautions and warnings for Cholecalciferol 4,000iu Injection:

• Avoid use in patients with known hypersensitivity to cholecalciferol (vitamin D3) or any other components of the injection.
• Use with caution in patients with hypercalcemia or hypercalciuria, as cholecalciferol may exacerbate these conditions.
• Regular monitoring of blood calcium levels is recommended during treatment to avoid complications such as hypercalcemia.
• Use with caution in patients with renal impairment, as cholecalciferol can lead to kidney damage or worsening of renal function if calcium levels become elevated.
• Patients with cardiovascular disease should be monitored for any adverse effects, as excessive calcium can lead to vascular calcification.
• Prolonged use or high doses of cholecalciferol can result in vitamin D toxicity, which can cause symptoms like nausea, vomiting, weakness, and confusion.
• Caution is advised in patients taking medications that may increase calcium levels, such as thiazide diuretics, as this may increase the risk of hypercalcemia.
• Cholecalciferol should be used during pregnancy only if clearly needed, as excessive vitamin D may harm the fetus. Consult a healthcare provider before use during pregnancy or breastfeeding.
• Patients with malabsorption disorders or conditions affecting fat absorption should be monitored closely, as vitamin D absorption may be impaired.
• Ensure proper dosing to prevent excessive intake, as overdose can lead to serious health complications.
• If signs of vitamin D toxicity occur, such as confusion, nausea, and dehydration, discontinue use and seek medical attention immediately.
• Always consult a healthcare provider before starting or adjusting the dosage of cholecalciferol, especially in patients with underlying health conditions.

Following are the drug interactions for Cholecalciferol 4,000 IU injection:

• Anticonvulsants like phenobarbital, phenytoin, or carbamazepine can reduce vitamin D effectiveness, requiring increased monitoring.
• Cholestyramine and colestipol may decrease vitamin D absorption, so it's recommended to separate doses by at least 4 hours.
• Thiazide diuretics can increase calcium levels, and concurrent use with vitamin D may require monitoring and dose adjustments.
• Orlistat may reduce vitamin D absorption, potentially necessitating higher vitamin D doses.
• Aluminum-containing antacids can decrease vitamin D absorption, so separate administration by 2 hours.
• Calcium supplements and calcium-containing medications may lead to hypercalcemia when used with vitamin D, requiring monitoring.
• Vitamin D may enhance the absorption of aluminum from aluminum-containing drugs, potentially increasing the risk of aluminum toxicity.

Following are the food interactions for Cholecalciferol 4,000 IU injection:

• Avoid high-fat meals as they may reduce the absorption of Cholecalciferol, which is a fat-soluble vitamin.
• Limit calcium-rich foods like dairy products, calcium-fortified juices, and certain vegetables, as excessive calcium intake can lead to hypercalcemia when combined with Cholecalciferol supplementation.
• Avoid excessive vitamin D-fortified foods like certain types of milk, orange juice, and cereals, as they can contribute to vitamin D toxicity when used alongside the injection.
• Restrict the consumption of fish liver oils and fatty fish like salmon and mackerel, as they naturally contain high levels of vitamin D, which may lead to an overdose.
• Grapefruit and grapefruit juice should be avoided, as they can interfere with vitamin D metabolism and increase the risk of side effects.
• Alcohol may decrease the effectiveness of vitamin D absorption, so it's best to limit or avoid it during treatment.
• Certain mineral oils and orlistat (a weight-loss medication) can impair the absorption of fat-soluble vitamins like Cholecalciferol, so they should be used cautiously or avoided.
• Always consult a healthcare professional for personalized advice, especially if you have a history of kidney or liver disease, as these conditions can affect vitamin D metabolism.

Cholecalciferol 4,000iu injection should be stored in a controlled environment, preferably in a cool and dry place, away from direct sunlight and moisture. The original packaging should be tightly sealed to maintain its integrity and prevent contamination. It is crucial to adhere to the recommended storage conditions to ensure the stability and effectiveness of the medication. When disposing of unused or expired injections, do not flush or pour them down the drain; instead, consult a pharmacist or healthcare professional for appropriate disposal methods. Keep the medication securely stored, out of children's reach, to prevent accidental exposure. Always exercise caution and follow the instructions provided by the manufacturer or healthcare provider regarding storage and disposal.

Following are the quick tips for Cholecalciferol 4,000iu injection:

• Ensure the injection is administered by a trained healthcare professional.
• Verify the dosage and injection site as directed by your doctor.
• Inform your doctor if you have any allergies or medical conditions.
• Report any pain, swelling, or redness at the injection site immediately.
• Store the injection as instructed by your pharmacist.
• Do not reuse or share needles; dispose of them safely.
• Maintain a balanced diet rich in vitamin D sources for overall health.
• Regularly monitor your vitamin D levels as advised by your healthcare provider.