KONAKION IMP 10MG INJ 10'S

Phytomenadione, also known as vitamin K1, works by promoting blood clotting or coagulation. Its primary mechanism of action involves participating in the synthesis of clotting factors in the liver. When administered, phytomenadione acts as a cofactor for enzymes responsible for carboxylating specific glutamic acid residues in vitamin K-dependent proteins. This carboxylation process is essential for the activation of clotting factors II, VII, IX, and X, as well as proteins C and S, which are crucial for the normal coagulation cascade. By facilitating the production of these clotting factors, phytomenadione helps restore the body's ability to form blood clots and prevent excessive bleeding.

Vitamin K

Injection

The following are the uses of Phytomenadione 10MG Injection:

• Used for reversing the effects of anticoagulant drugs, especially in cases of bleeding due to excessive warfarin.
• Used for preventing bleeding in newborns with vitamin K deficiency.
• Used to treat bleeding caused by liver disease or certain medical conditions affecting blood clotting.
• Used for rapid correction of elevated prothrombin time (PT) in emergency situations.
• Used to manage bleeding during surgical procedures, ensuring better control and faster recovery.
• Used to manage certain bleeding disorders, offering a quick and effective response.
• Used as a prophylactic measure to prevent bleeding complications in high-risk patients.
• Used in specific cases of poisoning to counteract the effects of certain toxins.

In the case of an overdose of Phytomenadione 10MG Injection, it is important to recognize the potential signs and symptoms. These may include nausea, vomiting, diarrhea, and in severe cases, a decrease in blood clotting ability. If an overdose is suspected, seek medical advice promptly. Treatment may involve supportive care and monitoring of vital signs, with specific measures tailored to the individual's condition and the severity of the overdose.

In the case of a missed dose of Phytomenadione 10MG Injection, it is important to administer the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, consult your healthcare professional for advice on how to safely resume the medication and ensure the correct dosage is administered.

To administer Phytomenadione 10MG Injection, gently insert the needle into the vial, withdraw the prescribed dose, and inject it intramuscularly or subcutaneously, following the healthcare provider's instructions, ensuring proper hygiene and handling during the process.

Here are the situations when Phytomenadione 10MG Injection should not be used:

• Should not be used in individuals with a known allergy or hypersensitivity to Phytomenadione or any of its components.
• Not recommended for newborn infants with a known or suspected condition of vitamin K deficiency bleeding (VKDB) type 1, as it may not provide sufficient protection.
• Contraindicated in patients with a history of hyperbilirubinemia or jaundice, especially in newborns, as it can increase the risk of bilirubin-induced brain damage.
• Should not be used in individuals with a history of blood clotting disorders or those taking anticoagulant medications, as it may interfere with the blood-clotting process.
• Not suitable for patients with a known or suspected liver disease, as it can affect the metabolism and clearance of Phytomenadione.
• Avoid using in individuals with a history of severe kidney impairment, as the excretion of Phytomenadione may be altered.

The side effects of Phytomenadione 10MG Injection may include:

• Skin rash or itching
• Slow or irregular heartbeat
• Difficulty breathing
• Swelling of the face, lips, or throat
• Severe dizziness
• Severe allergic reactions
• Pain or swelling at the injection site
• Nausea or vomiting

Following are the precautions and warnings for Phytomenadione 10MG Injection:

• This medication should not be administered to individuals with a known allergy to vitamin K or any of its derivatives.
• Patients with a history of liver disease or blood clotting disorders should use this medication with caution, as it can affect blood clotting.
• It may interact with anticoagulant medications, so patients taking blood thinners should inform their healthcare provider to adjust the dosage accordingly.
• Caution is advised in pregnant women, especially during the last trimester, as high doses may cause jaundice in newborns.
• Breastfeeding women should consult their doctor, as small amounts of the drug can pass into breast milk.
• For newborns, it is crucial to monitor the dosage and response carefully, as excessive doses may lead to toxicity.
• Patients with conditions affecting vitamin K absorption, such as cystic fibrosis or short bowel syndrome, may require higher doses.

Following are the drug interactions for Phytomenadione 10MG Injection:

• Anticoagulants like warfarin may have their effects reduced, potentially leading to a risk of blood clotting.
• Barbiturates and rifampicin can decrease the activity of phytomenadione, resulting in reduced therapeutic effects.
• Concomitant use with high doses of vitamin K2 (menaquinone) may lead to excessive vitamin K levels and potential side effects.
• Mineral oil and Orlistat can decrease the absorption of phytomenadione, potentially reducing its effectiveness.
• Cholestyramine and colestipol may reduce the absorption and effectiveness of phytomenadione.
• Anticonvulsants like phenytoin, phenobarbital, and carbamazepine can decrease phytomenadione levels, requiring monitoring and dose adjustments.
• Salicylates and sulfonamides may interfere with the action of phytomenadione, requiring close observation for bleeding.

Following are the food interactions to consider with Phytomenadione 10MG Injection:

• Avoid consuming large amounts of foods rich in vitamin K, such as leafy green vegetables (spinach, kale), broccoli, Brussels sprouts, and liver, as they can decrease the effectiveness of Phytomenadione.
• Maintain a consistent diet with a stable vitamin K intake before and during treatment to ensure predictable blood clotting responses.
• Avoid excessive alcohol consumption as it can interfere with the body's ability to absorb and utilize vitamin K, potentially affecting blood clotting.
• Grapefruit and grapefruit juice should be consumed with caution, as they may affect the liver enzymes responsible for metabolizing certain medications, although the interaction with Phytomenadione is not well established.
• Ensure you inform your healthcare provider about your regular diet and any significant changes to it, especially if you have a history of bleeding disorders or liver issues.
• Consider consulting a dietician or nutritionist to develop a well-balanced diet plan that supports your overall health and complements the medication's effects.
• Always follow the dosage and administration instructions provided by your healthcare professional to ensure the safe and effective use of Phytomenadione injections.

Phytomenadione 10MG Injection should be stored in a controlled environment, preferably in a cool and dry place, away from direct sunlight and moisture. It is crucial to maintain a temperature range between 20°C and 25°C (68°F to 77°F) for optimal storage conditions. Keep the injection in its original packaging, ensuring the seal is intact, to prevent contamination. Do not freeze the injection as it may affect its potency. When disposing of the medication, follow local guidelines for pharmaceutical waste disposal, and do not discard it in regular household trash or pour it down the drain. Proper disposal ensures the protection of the environment and prevents accidental exposure to the medication. Keep the injection out of children's reach to avoid accidental administration.

Following are the quick tips for Phytomenadione 10MG Injection:

• Administer the injection under medical supervision for safe and effective use.
• Ensure the injection is given into the muscle or vein as directed by the healthcare provider.
• Follow the prescribed dosage and do not self-inject without proper training.
• Inform your doctor if you have any allergies or are taking other medications.
• Store the injection at room temperature, away from direct sunlight and moisture.
• Do not use if the solution appears cloudy or contains particles.
• Dispose of used needles and syringes safely in designated sharps containers.