Konakion (10mg) 10 Dragees

Phytomenadione, also known as vitamin K1, has a specific mechanism of action related to its role in blood coagulation. It acts as a cofactor for the enzyme vitamin K epoxide reductase (VKOR), which is essential for the carboxylation of glutamic acid residues in certain proteins involved in the coagulation cascade. Specifically, phytomenadione helps to activate clotting factors II, VII, IX, and X, as well as proteins C and S, by facilitating the conversion of their glutamic acid residues into gamma-carboxyglutamic acid (Gla). This carboxylation process is crucial for the proper functioning of these proteins, enabling them to bind calcium ions and subsequently, promote blood clotting and prevent excessive bleeding. Thus, the primary mechanism of action of Phytomenadione 10mg Dragee is to restore the normal clotting function in individuals with vitamin K deficiency or those taking medications that interfere with vitamin K metabolism.

Vitamin K

Dragee

The following are the uses of Phytomenadione 10mg Dragee:

• Used for preventing and treating vitamin K deficiency bleeding in newborns.
• Used for promoting blood clotting and preventing excessive bleeding.
• Used for counteracting the effects of blood-thinning medications.
• Used for supporting liver function and aiding in the production of blood clotting factors.
• Used for managing certain bleeding disorders and malabsorption issues.
• Used for surgical procedures to ensure proper blood clotting.
• Used for promoting wound healing and preventing post-operative bleeding.
• Used for maintaining bone health, as vitamin K plays a role in bone metabolism.

In the case of an overdose of Phytomenadione 10mg Dragee, individuals may experience symptoms such as nausea, vomiting, diarrhea, and abdominal pain. These symptoms can occur within a few hours of ingestion. It is important to recognize that this medication should not be taken in excess, and any accidental or intentional overdose requires prompt medical attention. Seeking medical advice and treatment is crucial to managing the potential adverse effects and ensuring a safe recovery.

In the case of a missed dose of Phytomenadione 10mg Dragee, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. It is recommended to set reminders or use a pill organizer to help you remember to take your medication on time and reduce the chances of missing doses.

To take Phytomenadione 10mg Dragee, swallow the tablet whole with a glass of water, following the prescribed dosage and schedule provided by your healthcare professional, without crushing or chewing the tablet.

Following are the conditions or circumstances when Phytomenadione 10mg Dragee should not be taken:

• Phytomenadione 10mg Dragee should not be used in individuals with a known allergy or hypersensitivity to vitamin K or any of the excipients in the formulation.
• Contraindicated in individuals with a history of severe allergic reactions to other forms of vitamin K.
• Not suitable for patients with a rare hereditary condition called vitamin K-dependent clotting factor deficiency or deficiency state.
• Should not be used to treat vitamin K deficiency caused by certain medications or medical conditions without medical supervision.
• Avoid using in individuals with a history of liver disease or impaired liver function, as this may affect vitamin K metabolism.
• Contraindicated in patients with a history of blood clots or conditions that increase the risk of blood clots, such as deep vein thrombosis (DVT) or pulmonary embolism.
• Not recommended for individuals with a history of jaundice or other liver-related issues.

The side effects of Phytomenadione 10mg Dragee may include:

• Allergic reactions such as skin rash, itching, or hives.
• Nausea and vomiting.
• Diarrhea or loose stools.
• Stomach pain or cramps.
• Headache or dizziness.
• Mild itching or burning at the injection site.
• Temporary fatigue or weakness.
• In rare cases, anaphylaxis (severe allergic reaction).

Following are the precautions and warnings for Phytomenadione 10mg Dragee:

• Do not use if you are allergic to any of the ingredients, including Phytomenadione or other related compounds.
• This medication should be used with caution in patients with liver disease or a history of liver-related problems, as it can affect liver function.
• Patients with a history of blood disorders or those taking anticoagulant medications should be closely monitored while using this drug.
• Avoid excessive alcohol consumption while taking Phytomenadione as it may interfere with the medication's effectiveness.
• If you are pregnant, breastfeeding, or planning to become pregnant, consult your doctor before taking this medication.
• Do not exceed the recommended dosage, as high doses may lead to adverse effects and potential toxicity.
• Keep out of reach of children. Store in a cool, dry place, away from direct sunlight.

Following are the drug interactions for Phytomenadione 10mg Dragee:

• Anticoagulants like warfarin may have reduced effects, as Phytomenadione can decrease the anticoagulant activity of these drugs. Close monitoring of INR is recommended.
• Barbiturates and other drugs that induce liver enzymes may decrease the duration of action of Phytomenadione, potentially requiring higher doses.
• The effectiveness of vitamin K antagonists (e.g., acenocoumarol, phenprocoumon) can be reduced, necessitating closer monitoring and potential dose adjustments.
• Cholestyramine can bind with Phytomenadione in the gastrointestinal tract, reducing its absorption and effectiveness. Separate administration by at least 4 hours.
• The use of high doses of vitamin A, D, or E concurrently with Phytomenadione may increase the risk of toxicity due to fat-soluble vitamin accumulation.
• Mineral oil and other laxatives can interfere with the absorption of Phytomenadione, potentially reducing its effectiveness.
• The absorption of Phytomenadione may be reduced when taken with bile acid sequestrants (e.g., cholestyramine, colestipol), requiring a separation in dosing times.
• Phytomenadione may interact with other fat-soluble vitamins, particularly in cases of high-dose supplementation, potentially leading to imbalances or adverse effects.

Following are the food interactions for Phytomenadione 10mg Dragee:

• Avoid high-dose vitamin K-rich foods like spinach, kale, broccoli, and Brussels sprouts while taking this medication, as excessive vitamin K intake can counteract the intended effects of the drug.
• Green tea and herbal teas containing vitamin K should be consumed in moderation, as they may reduce the drug's effectiveness.
• Cranberry juice and cranberry products might interfere with the drug's action and should be used cautiously.
• Consuming large amounts of soybean-based foods like tofu, soy milk, and edamame can potentially impact the drug's metabolism.
• Garlic, ginger, and turmeric supplements may interact with Phytomenadione's blood-clotting properties and should be used with caution.
• Avoid excessive alcohol consumption as it may interfere with the body's ability to absorb and utilize vitamin K effectively.
• Consult a healthcare professional if you regularly consume large amounts of liver, a rich source of vitamin K, as it may require dosage adjustments.
• Always inform your healthcare provider about your dietary habits to ensure the medication's effectiveness and safety.

Phytomenadione 10mg Dragee should be stored in a secure and dry location, preferably in its original packaging, ensuring the container is tightly sealed to maintain its integrity. Maintain a consistent room temperature, avoiding exposure to direct sunlight, heat sources like radiators, or extreme temperature fluctuations, as these can compromise the drug's effectiveness. Always verify the expiration date on the packaging, and never use the medication beyond this date. When disposing of unused or expired dragees, do not flush them or pour them down the drain. Instead, consult your pharmacist or local waste management guidelines for safe disposal practices to protect the environment. Additionally, keep the medication out of children's reach to prevent accidental consumption, ensuring their safety.

Following are the quick tips for Phytomenadione 10mg Dragee:

• Store the medication in a cool, dry place, away from direct sunlight and moisture.
• Ensure you complete the full course of treatment as prescribed by your doctor.
• Swallow the dragee whole without chewing or crushing it for optimal absorption.
• Take the dragee with a full glass of water for easy swallowing.
• Avoid taking antacids or dairy products within 2 hours of taking this medication.
• Do not take this medicine with vitamin K-rich foods like leafy greens, as it may reduce its effectiveness.
• Inform your doctor if you have any allergies or are taking other medications.