Cosart-50 (50mg) 200 Tablets

Losartan: Angiotensin II Receptor Blocker. Losartan selectively and competitively blocks angiotensin II receptors at the AT1 receptor site, this mechanism results in a compensatory increase in levels of renin and angiotensin. This drug binds with AT1 receptors with high affinity and is more than 10000 fold selective for the AT1 receptor than the AT2 receptor. It works by inhibiting angiotensin II-induced vasopressin release, release of adrenal catecholamine, inhibits rapid and slow pressor response, thirst, hyperplasia and cellular hypertrophy, noradrenergic neurotransmission, and increase in sympathetic tone. Losartan also inhibits angiotensin II-induced action of aldosterone and vasoconstriction, which results in lowering of blood pressure. Losartan increases the urinary flow, and excretion of; sodium, potassium, chloride, magnesium, calcium, uric acid and phosphate. In comparison to ACE inhibitors, angiotensin II-receptor blockers effectively inhibit the renin-angiotensin system, while not affecting the response to bradykinin.

Losartan potassium

Tablet

Hypertension (High Blood Pressure)

Dose must be taken according to the doctor’s advice only; doses given below are suggested as supportive literature for better understanding in some areas of requirements. Adult dose: For hypertension and Hypertension with Left Ventricular Hypertrophy, Nephropathy in Type 2 Diabetes: initial dose is 50mg orally a day; may increase up to 100mg per day. Dose modification in hepatic impairment: initial dose is 25mg orally a day. Dose in children ≥6 years and adolescents: Children ≥6 years and Adolescents, oral initial, 0.7mg/kg once daily, maximum daily dose is 100mg per day.

Consult your doctor in case of overdose as it may cause hypotension.

In case you missed any dose, take the next dose as soon as you remember, but don't double your next dose to compensate for the missed one.

Take it orally according to your doctor’s advice.

When pregnancy is detected, discontinue losartan as soon as possible.

Hyperkalemia Edema Hypotension Renal Artery Stenosis Or Volume Depletion.

It may cause headache or dizziness after the first dose.

Losartan may enhance the hypotensive effect of antipsychotic agents.