KYTRIL 1MG TAB

Granisetron 1MG Tablet's primary mechanism of action involves blocking serotonin (5-hydroxytryptamine type 3 or 5-HT3) receptors in the brain's chemoreceptor trigger zone and gastrointestinal tract. By selectively antagonizing these receptors, the drug effectively inhibits serotonin-mediated signals that trigger nausea and vomiting. This mechanism makes granisetron particularly useful in preventing and treating nausea and vomiting associated with chemotherapy and radiotherapy.

Granisetron 1MG

5-HT3 receptor antagonist

Tablet

The following are the uses of Granisetron 1MG Tablet:

• Used for preventing and treating nausea and vomiting caused by chemotherapy and radiation therapy.
• Used to manage post-operative nausea and vomiting.
• Used for relieving nausea and vomiting in acute gastroenteritis.
• Used for treating nausea and vomiting associated with acute migraine.
• Used to reduce vomiting and improve well-being in patients with gastroenteritis.
• Used to prevent and treat nausea and vomiting in patients with severe acute pancreatitis.
• Used to control chemotherapy-induced nausea and vomiting, improving patient comfort.

In the case of an overdose of Granisetron 1MG Tablets, the severity of symptoms may vary. Common signs include dizziness, headache, and gastrointestinal issues like nausea or diarrhea. In more severe cases, individuals may experience low blood pressure, fainting, or abnormal heart rhythms. It is crucial to seek medical advice promptly, as treatment may involve monitoring vital signs, providing supportive care, and administering appropriate medications to manage symptoms and ensure the patient's well-being.

In the case of a missed dose of Granisetron 1MG Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next scheduled dose, it is recommended to skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to adjust your dosing schedule and ensure the medication's effectiveness.

To take Granisetron 1MG Tablet, place the tablet on your tongue and allow it to dissolve completely, preferably before a meal, following the dosage instructions provided by your healthcare professional.

Here are the conditions or situations when Granisetron 1MG Tablet should not be used:

• Do not use if you have a known allergy or hypersensitivity to Granisetron or any of its excipients.
• Contraindicated in patients with known prolonged QT syndrome or congenital long QT syndrome.
• Should not be used if you have a blockage in your digestive system (gastrointestinal obstruction).
• Not recommended for patients with severe liver impairment.
• Avoid use if you have a history of phenylketonuria, as some Granisetron formulations may contain phenylalanine.
• Do not use if you have ever had an abnormal heart rhythm (arrhythmia) or a slow heartbeat (bradycardia).
• Contraindicated in patients with severe constipation.
• Should not be used if you have a family history of Long QT syndrome.

The side effects of Granisetron 1MG Tablet may include:

• Headache
• Constipation
• Diarrhea
• Dizziness
• Fatigue or weakness
• Skin rash or itching
• Transient increases in liver enzymes
• Mild abdominal pain

Following are the precautions and warnings for Granisetron 1MG Tablet:

• Do not use if you are allergic to Granisetron or any other similar medications.
• Patients with liver or kidney disease should use with caution as it may require dosage adjustments.
• This medication may cause dizziness, so avoid driving or operating heavy machinery until you know how it affects you.
• Alcohol consumption should be avoided as it may increase the risk of side effects.
• Do not crush or chew the tablet; swallow it whole to ensure proper absorption.
• Elderly patients may be more sensitive to the side effects, so regular monitoring is advised.
• Consult your doctor if you have a history of heart problems before taking this medication.

Following are the drug interactions for Granisetron 1MG Tablet:

• Concomitant use with apomorphine may result in increased risk of adverse effects like extrapyramidal reactions.
• It may reduce the efficacy of levodopa, possibly requiring adjustment of its dose.
• Granisetron may increase plasma levels of ondansetron, potentially leading to increased adverse effects.
• Prochlorperazine's absorption may be reduced when taken with granisetron, impacting its effectiveness.
• The effectiveness of tricyclic antidepressants might be reduced when used with granisetron.
• It may increase the bioavailability of halofantrine, potentially leading to increased side effects.
• Granisetron can increase plasma levels of paclitaxel, potentially increasing the risk of toxicity.

Following are the food interactions for Granisetron 1MG Tablet:

• Avoid grapefruit and grapefruit juice as they may decrease the metabolism of Granisetron, leading to increased drug levels in the body and potentially causing more side effects.
• Alcohol consumption should be limited or avoided as it may enhance the sedative effects of Granisetron, resulting in increased dizziness and drowsiness.
• High-fat meals can decrease the absorption of Granisetron, possibly reducing its effectiveness. It is recommended to take the medication on an empty stomach or with a light meal.
• Caffeine-rich foods and beverages should be consumed in moderation as they may interact with Granisetron, affecting its metabolism and potentially increasing side effects.
• Avoid eating large amounts of chocolate, especially dark chocolate, as it contains a compound that can inhibit the metabolism of Granisetron, leading to higher drug levels in the body.
• Consuming large quantities of fiber-rich foods may affect the absorption of Granisetron, so it is advisable to maintain a balanced diet and not overindulge in high-fiber foods.
• Herbal supplements like St. John's Wort should be used with caution as they can affect the metabolism of Granisetron, potentially reducing its effectiveness.
• Always follow the advice of your healthcare provider regarding any specific dietary restrictions or recommendations while taking Granisetron.

Granisetron 1MG Tablets should be stored in a cool and dry place, preferably at room temperature, ensuring protection from light and moisture. The medication bottle should be tightly sealed to maintain its integrity and effectiveness. It is crucial not to expose the tablets to excessive heat or cold, so avoid storing them in the bathroom or near hot appliances. Always check the expiration date, and if the tablets are past their prime or no longer needed, proper disposal is essential. Avoid flushing or pouring them down the drain; instead, consult a pharmacist or healthcare professional for guidance on safe disposal methods. Keep the medication away from children to prevent accidental consumption.

Following are the quick tips for Granisetron 1MG Tablet:

• Take the tablet as directed by your doctor, usually 1-2 hours before chemotherapy or radiation therapy.
• Swallow the tablet whole with a glass of water; do not crush, chew, or break it.
• If you experience nausea, take the tablet as soon as you remember, and then adjust the timing of your next dose accordingly.
• Avoid driving or operating machinery until you know how this medication affects you.
• Inform your doctor about all medications you are taking to ensure safe use.
• Store the tablets at room temperature, away from moisture and light.
• Do not share your medication with others, even if they have similar symptoms.