KYTRIL 3MG/3ML AMP

Granisetron 3MG Injection, a potent and highly selective 5-HT3 receptor antagonist, exerts its mechanism of action by blocking serotonin (5-hydroxytryptamine, 5-HT) from binding to 5-HT3 receptors in the chemoreceptor trigger zone and gastrointestinal tract. This blockade inhibits the stimulation of the vomiting center in the medulla oblongata, thereby suppressing nausea and vomiting. Specifically, granisetron's affinity for 5-HT3 receptors prevents the initiation of the vomiting reflex, making it effective in the management of nausea and vomiting associated with chemotherapy and radiotherapy.

Granisetron 3MG

5-HT3 receptor antagonist.

Injection

The following are the uses of Granisetron 3MG Injection:

• Used for preventing and treating nausea and vomiting caused by chemotherapy.
• Used to manage post-operative nausea and vomiting (PONV) after surgeries.
• Used to relieve severe nausea and vomiting during pregnancy.
• Used to alleviate nausea and vomiting associated with acute gastroenteritis.
• Used to control symptoms in patients with chronic conditions causing frequent nausea.
• Used to enhance patient comfort and improve treatment adherence.
• Used as an alternative for patients who cannot take oral anti-nausea medications.
• Used to prevent dehydration and improve quality of life during medical treatments.

In the case of an overdose of Granisetron 3MG Injection, it is important to recognize the potential symptoms and take appropriate action. Common signs of overdose may include dizziness, headache, and blurred vision. If an overdose is suspected, immediate medical advice should be sought. Treatment may involve supportive care, and healthcare professionals should be informed about the specific circumstances of the overdose to ensure the best possible management and care for the patient.

In the case of a missed dose of Granisetron 3MG Injection, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you have missed multiple doses, contact your healthcare provider for guidance on how to safely adjust your dosing schedule to ensure maximum effectiveness of the medication.

To administer Granisetron 3MG Injection, gently inject the entire contents of the pre-filled syringe or vial under the skin (subcutaneously) or into a muscle (intramuscularly) as directed by your healthcare professional, typically 1 to 3 times a day, following the dosage instructions provided.

Here are the conditions or situations when Granisetron 3MG Injection should not be used:

• Should not be administered to individuals with a known hypersensitivity or allergy to Granisetron or other similar medications.
• Contraindicated in patients with known prolonged QT intervals or congenital long QT syndrome.
• Not recommended for individuals with severe renal impairment (kidney disease) without adjusting the dose.
• Should be avoided in patients with a history of severe cardiovascular disease or those at risk of arrhythmias.
• Not suitable for use in patients with known or suspected bowel obstruction.
• Contraindicated during breastfeeding as it may pass into breast milk.
• Should not be used in children below 2 years of age due to limited safety data.

The side effects of Granisetron 3MG Injection may include:

• Headache
• Constipation
• Diarrhea
• Dizziness
• Fatigue
• Skin rash
• Transient increases in liver enzymes

Following are the precautions and warnings for Granisetron 3MG Injection:

• Do not use Granisetron if you are allergic to any of its ingredients.
• This medication should be used with caution in patients with liver or kidney disease, as it may require dosage adjustments.
• Granisetron may cause temporary vision changes; patients should be cautious when driving or operating machinery until they know how the medication affects them.
• Elderly patients may be more sensitive to the side effects, especially heart-related issues.
• It should be used with caution in patients with a history of heart problems, as it may affect heart rhythm.
• Granisetron may interact with other medications, so inform your doctor about all the medicines you are currently taking.
• This injection should be administered by a healthcare professional, and any signs of an allergic reaction should be reported immediately.

Following are the drug interactions for Granisetron 3MG Injection:

• Avoid concurrent use with apomorphine as it may reduce the therapeutic effect of apomorphine.
• Granisetron may increase the plasma concentration of buprenorphine, potentially requiring dose adjustments.
• Concomitant use with other serotonin-modulating drugs, such as SSRIs or SNRIs, may increase the risk of serotonin syndrome.
• The effects of tramadol may be decreased when used with granisetron.
• Granisetron can increase the blood levels of 5-fluorouracil, potentially requiring dose adjustments.
• It may reduce the absorption of ethinyl estradiol and levonorgestrel when taken orally.
• The use of St. John's Wort may decrease the plasma concentration of granisetron, reducing its effectiveness.

Following are the food interactions for Granisetron 3MG Injection:

• Grapefruit consumption should be avoided as it can increase the levels of Granisetron in the blood, leading to potential side effects.
• Alcoholic beverages should be limited or avoided as they can increase the sedative effects and cause dizziness.
• Consuming high-fat meals before or after taking the injection may slightly delay the absorption of Granisetron.
• Avoid excessive caffeine intake as it can interact with Granisetron and increase the risk of side effects.
• Spicy foods may not directly interact with the medication, but they can potentially aggravate gastrointestinal symptoms in some individuals.
• Dairy products are generally safe but consult your doctor if you have any specific concerns or allergies.
• It is advisable to maintain a balanced diet and stay well-hydrated during treatment with Granisetron injections.
• Always follow the dietary recommendations provided by your healthcare professional for optimal treatment outcomes.

Granisetron 3MG Injection should be stored in a controlled environment, preferably in a cool and dry place with a temperature between 68°F and 77°F (20°C and 25°C). Protect the injection from direct sunlight, heat, and moisture to maintain its integrity. Always keep the medication in its original packaging, ensuring the seal is intact, to prevent contamination. It is crucial to adhere to the recommended storage conditions to preserve the effectiveness of the medication. When disposing of unused or expired Granisetron injections, do not flush or pour them down the drain. Instead, follow local guidelines or consult a pharmacist for safe disposal methods to minimize environmental impact. Keep the medication securely stored, out of the reach of children and pets, to prevent accidental exposure.

Following are the quick tips for Granisetron 3MG Injection:

• Administer the injection as directed by your doctor, typically 1-2 hours before chemotherapy or radiation.
• Ensure the injection is given by a trained healthcare professional.
• Inform your doctor if you have any allergies or medical conditions before receiving the injection.
• Avoid driving or operating machinery immediately after the injection as dizziness may occur.
• Stay hydrated and maintain a balanced diet to support overall health during treatment.
• Report any severe side effects like allergic reactions or breathing difficulties to your doctor promptly.
• Store the injection as instructed on the packaging, usually at room temperature, away from light and moisture.