LACRI LUBE SOP 3.5G

Bimatoprost is a prostaglandin analog that primarily works by increasing the outflow of aqueous humor from the eye, thereby reducing intraocular pressure (IOP). Its mechanism of action involves binding to prostaglandin receptors on the ciliary muscle and trabecular meshwork cells. This binding stimulates an increase in the expression of matrix metalloproteinases, which enhances the remodeling of the extracellular matrix in the trabecular meshwork. As a result, the resistance to aqueous humor outflow is reduced, allowing for improved drainage and a subsequent decrease in IOP. Bimatoprost also causes slight changes in the morphology of the ciliary muscle, leading to an increase in uveoscleral outflow, which further contributes to its overall IOP-lowering effect.

Bimatoprost

Prostaglandin analog

Ointment

The following are the uses of Bimatoprost Ointment:

• Used for treating hypotrichosis, a condition of inadequate eyelash growth.
• Used to enhance eyelash prominence, length, and thickness.
• Used for glaucoma and ocular hypertension, reducing intraocular pressure.
• Used to treat open-angle glaucoma or ocular hypertension.
• Used for cosmetic purposes, darkening eyelashes and making them more noticeable.
• Used as a treatment for inadequate eyelash growth due to medical conditions.
• Used to improve the overall appearance of the eyes by promoting eyelash growth.

In the case of an overdose of Bimatoprost Ointment, it is important to recognize the potential risks and take appropriate action. The severity of symptoms may vary depending on the amount ingested. Common signs include eye redness, itching, and irritation. If a significant amount is swallowed, it could lead to more serious effects such as severe gastrointestinal issues, dizziness, and even changes in heart rate. Promptly seeking medical advice is crucial to ensure proper treatment and management of any adverse effects.

In the case of a missed dose of Bimatoprost Ointment, it is important to apply the medication as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not apply extra ointment to make up for the missed dose, as this may increase the risk of side effects. If you frequently miss doses, consider setting reminders or using a medication tracker to help you stay on track with your treatment plan. Consult your healthcare provider if you have any concerns or questions regarding missed doses.

To apply Bimatoprost Ointment, wash your hands first, then using a clean fingertip or an applicator, gently apply a thin layer of the ointment along the upper lash line of your eyelid, once a day, as directed by your healthcare professional.

Following are the conditions/situations when Bimatoprost Ointment should not be used:

• Should not be used if you have an eye or eyelid infection, or any other eye condition that could make the use of this medication unsafe.
• Contraindicated in individuals with a known allergy or sensitivity to Bimatoprost or any of its ingredients.
• Not suitable for those with a history of severe respiratory issues or asthma.
• Should not be used if you have had recent eye surgery or plan to have eye surgery in the near future.
• Avoid using it if you have uveitis or any inflammation inside the eye.
• Do not use Bimatoprost if you have narrow-angle glaucoma, as it can further reduce the drainage of fluid from the eye.
• Not recommended for individuals with a history of macular edema or retinal detachment.
• Should not be applied if you are currently using other eye medications without consulting a doctor.

The side effects of Bimatoprost Ointment may include:

• Eye redness
• Itching or irritation around the eyes
• Darkening of the iris (the colored part of the eye)
• Eyelash growth (including increased length, thickness, and darkness)
• Dry eyes
• Blurred vision
• Eyelid swelling
• Sensitivity to light

Following are the precautions and warnings for Bimatoprost Ointment:

• This medication is for external use only and should be applied directly to the affected area as directed. Avoid contact with eyes, mouth, and open wounds.
• Do not use Bimatoprost Ointment if you have a known allergy to any of its ingredients. Seek medical attention if you experience signs of an allergic reaction.
• It may cause a temporary darkening of the skin around the treated area, especially in patients with light skin. This effect is usually reversible after discontinuation.
• Bimatoprost can cause a gradual change in eye color, increasing the amount of brown pigment. This change may be permanent, so use with caution.
• If you have a history of eye problems such as uveitis or glaucoma, use this medication with caution and under medical supervision.
• Pregnant and breastfeeding women should consult their healthcare provider before using Bimatoprost Ointment, as its effects during these periods are not fully established.
• Keep the medication out of reach of children and pets. If accidental ingestion occurs, seek medical attention immediately.
• Store Bimatoprost Ointment at room temperature, away from direct sunlight, and do not freeze.

Following are the drug interactions for Bimatoprost Ointment:

• Concomitant use with other intraocular pressure-lowering medications, such as timolol, may have additive effects and further reduce eye pressure.
• Bimatoprost may interact with ocular corticosteroids, potentially increasing the risk of ocular hypertension or glaucoma.
• It can enhance the effects of certain immunosuppressants, leading to increased ocular side effects.
• The absorption of Bimatoprost can be affected by ophthalmic drugs containing cationic preservatives, such as benzalkonium chloride.
• Use with contact lenses is not recommended, as the ointment may contain preservatives that can be absorbed by the lenses.
• Topical ophthalmic beta-blockers may have reduced effects when used with Bimatoprost, as it may interfere with their absorption.
• Prostaglandin analogs, when used concurrently, may increase the risk of iris pigmentation changes and eyelash growth.

Following are the food interactions to consider with Bimatoprost Ointment:

• Bimatoprost may increase the sensitivity of your eyes to sunlight; avoid excessive exposure to bright light or sunlight. It is advisable to wear sunglasses and a hat for protection.
• No specific food restrictions are associated with Bimatoprost Ointment, but maintaining a healthy diet is generally recommended for overall eye health.
• Some studies suggest that consuming a diet rich in omega-3 fatty acids, found in fish like salmon and tuna, may support eye health and reduce the risk of eye conditions.
• Antioxidant-rich foods like colorful vegetables and fruits (e.g., carrots, spinach, berries) may also be beneficial for eye health and can be included in your diet.
• Avoid excessive caffeine intake, as it may increase eye pressure, especially if you have glaucoma or are at risk of it.
• Limit the consumption of highly processed foods and sugary snacks, as they may contribute to inflammation and potentially impact eye health negatively.
• Staying well-hydrated by drinking enough water is essential for maintaining overall health, including eye hydration.

Bimatoprost Ointment should be stored with care to ensure its effectiveness and safety. Keep the ointment in a cool, dry place, preferably at room temperature, and avoid exposure to direct sunlight or excessive heat. The original container should be tightly sealed to maintain its integrity and prevent contamination. It is crucial not to store the ointment in the bathroom or near any heat sources, as temperature fluctuations can impact its quality. Always check the expiration date, and if the ointment is expired or no longer needed, proper disposal is essential. Do not dispose of it in drains or toilets; instead, consult a pharmacist or healthcare professional for guidance on safe disposal methods. Keep the ointment out of children's reach to prevent accidental contact or ingestion.

Following are the quick tips for Bimatoprost Ointment:

• Wash your hands before applying the ointment to ensure a clean application.
• Apply a thin layer to the affected area as directed by your doctor.
• Avoid applying the ointment to the eyes or other sensitive areas unless prescribed.
• Use the ointment consistently as prescribed for maximum effectiveness.
• Do not share your medication with others, even if they have similar symptoms.
• Store the ointment at room temperature, away from direct sunlight and moisture.
• Inform your doctor if you have any eye conditions or are using other eye medications.