Lafaxine ER (100mg) 14 Tablets

Desvenlafaxine 100mg Tablet, an active metabolite of venlafaxine, primarily exerts its therapeutic effects through selective inhibition of serotonin and norepinephrine reuptake in the brain. By inhibiting the reuptake of these neurotransmitters, desvenlafaxine enhances their availability in the synaptic cleft, leading to increased neurotransmission. This mechanism of action is believed to contribute to the improvement of mood and emotional regulation in individuals with major depressive disorder. Desvenlafaxine has a higher affinity for the serotonin transporter than the norepinephrine transporter, resulting in a more pronounced effect on serotonin reuptake inhibition.

Desvenlafaxine 100mg

Serotonin-norepinephrine reuptake inhibitor (SNRI)

Tablet

The following are the uses of Desvenlafaxine 100mg Tablet:

• Used for treating major depressive disorder in adults.
• Used to alleviate symptoms of depression such as persistent sadness, loss of interest, and lack of energy.
• Helps restore emotional balance and improve overall mood.
• Effective in enhancing communication between nerve cells in the brain.
• Aids in reducing the severity of depressive episodes and preventing their recurrence.
• Assists individuals in managing daily activities and improving quality of life.
• Used as part of a comprehensive treatment plan, often combined with therapy or counseling.

In the case of an overdose of Desvenlafaxine 100mg Tablets, immediate medical attention is necessary. Symptoms may include rapid heartbeat, dizziness, seizures, and in severe cases, a coma. Prompt action is vital as an overdose can lead to serious health complications. Treatment may involve monitoring vital signs, administering activated charcoal, and providing supportive care in a medical facility. It is important to seek professional advice and not delay treatment.

In the case of a missed dose of Desvenlafaxine 100mg Tablet, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Avoid taking extra doses to make up for the missed one, as this may increase the risk of side effects. If you miss several doses, contact your healthcare provider for advice on how to safely resume your medication. It is recommended to set a daily routine or use reminders to help you take your medication consistently and minimize missed doses.

To take Desvenlafaxine 100mg Tablet, swallow the tablet whole with a full glass of water, preferably at the same time each day, as directed by your healthcare professional, without crushing, chewing, or splitting the tablet.

Here are the conditions or situations when Desvenlafaxine 100mg Tablet should not be taken:

• Avoid if you have a known allergy or hypersensitivity to desvenlafaxine or any of its excipients.
• Do not use if you have recently taken a Monoamine Oxidase Inhibitor (MAOI) or are currently using an MAOI.
• Contraindicated in individuals with uncontrolled narrow-angle glaucoma.
• Not recommended for patients with severe liver impairment.
• Should not be used in patients with uncontrolled high blood pressure (hypertension).
• Avoid if you have a history of bleeding disorders or conditions that increase your risk of bleeding.
• Not suitable for individuals with a history of seizures or conditions that lower the seizure threshold.

The side effects of Desvenlafaxine 100mg Tablet may include:

• Nausea and vomiting
• Dry mouth
• Diarrhea or constipation
• Excessive sweating
• Dizziness or lightheadedness
• Insomnia or sleep disturbances
• Sexual dysfunction, including decreased libido or delayed orgasm
• Increased heart rate or blood pressure

Following are the precautions and warnings for Desvenlafaxine 100mg Tablet:

• Do not start or stop taking this medication without consulting your doctor, as sudden discontinuation may lead to withdrawal symptoms.
• Patients with a history of suicidal thoughts or attempts should be closely monitored, especially during the initial treatment period.
• Desvenlafaxine may increase the risk of bleeding, so inform your doctor if you have bleeding disorders or are taking blood thinners.
• This medication can cause an increase in blood pressure, so regular monitoring is necessary, especially in patients with hypertension.
• Elderly patients may be more sensitive to the side effects of Desvenlafaxine, so dosage adjustments might be required.
• It may cause drowsiness and dizziness, so patients should avoid driving or operating heavy machinery until they know how the medication affects them.
• Consult your doctor if you have a history of seizures, as Desvenlafaxine may lower the seizure threshold.

Following are the drug interactions for Desvenlafaxine 100mg Tablet:

• Concurrent use with other serotonin-norepinephrine reuptake inhibitors (SNRIs) or selective serotonin reuptake inhibitors (SSRIs) can lead to serotonin syndrome, a potentially serious condition.
• Taking Desvenlafaxine with monoamine oxidase inhibitors (MAOIs) is contraindicated, as it may result in severe reactions, including serotonin syndrome.
• It may increase the risk of bleeding when combined with anticoagulants such as warfarin, requiring close monitoring.
• Using Desvenlafaxine with central nervous system (CNS) depressants like benzodiazepines or alcohol can intensify their effects, leading to increased sedation and impaired cognitive function.
• Nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen may elevate the risk of bleeding when taken alongside Desvenlafaxine.
• Desvenlafaxine can affect the metabolism of certain medications, including some anticonvulsants and antipsychotics, potentially leading to increased side effects.
• Caution is warranted when combining Desvenlafaxine with drugs that influence liver enzymes, as this may alter its own metabolism.

Following are the food interactions for Desvenlafaxine 100mg Tablet:

• Avoid consuming alcohol as it may increase the risk of side effects like dizziness, drowsiness, and impaired judgment.
• Grapefruit and grapefruit juice should be consumed with caution as they can affect the metabolism of Desvenlafaxine, potentially leading to increased drug levels in the body.
• Caffeine intake should be monitored as it can enhance the effects of Desvenlafaxine on the central nervous system, possibly causing increased anxiety or insomnia.
• High-fat meals may slightly delay the absorption of Desvenlafaxine, but this is generally not clinically significant.
• Avoid foods rich in tyramine (aged cheeses, cured meats) as Desvenlafaxine can increase their effects, leading to potential blood pressure issues.
• No significant food interactions are known to affect the effectiveness of Desvenlafaxine directly, but maintaining a balanced diet is recommended.
• Always follow your healthcare provider's advice regarding dietary restrictions and interactions.
• Stay hydrated and maintain a healthy diet to support overall well-being during Desvenlafaxine treatment.

Desvenlafaxine 100mg Tablets should be stored in a secure and dry location, away from direct sunlight, moisture, and heat. Keep the tablets in their original container, tightly sealed, to maintain their integrity and effectiveness. It is crucial to store medications out of children's reach to prevent accidental consumption. Pay attention to the expiration date, and if the tablets are no longer needed or have expired, proper disposal is essential. Do not dispose of them in household garbage or down the drain; instead, consult your pharmacist or healthcare professional for guidance on safe disposal methods to minimize environmental impact. Remember to follow local regulations regarding medication disposal.

Following are the quick tips for Desvenlafaxine 100mg Tablet:

• Consult your doctor for the right dosage and duration based on your medical condition.
• Take the tablet at the same time each day to maintain consistent levels.
• Swallow the tablet whole with a full glass of water, preferably with food.
• Do not crush, chew, or break the tablet, unless advised by your doctor.
• Avoid alcohol consumption as it may increase side effects.
• Inform your doctor about all medications you take to prevent interactions.
• Store the medication in a cool, dry place, away from direct sunlight.
• Do not share your medication with others, even if they have similar symptoms.