LANOXIN 0.5MG INJ

Digoxin 0.5mg Injection, a cardiac glycoside, exerts its effects by inhibiting the sodium-potassium ATPase pump in cardiac myocytes. This inhibition leads to increased intracellular sodium levels, which subsequently stimulates the sodium-calcium exchanger to extrude more calcium from the cell. The rise in intracellular calcium concentration enhances myocardial contractility, improving cardiac output. Additionally, Digoxin slows down the conduction of electrical impulses through the atrioventricular (AV) node, leading to a reduction in heart rate and increased diastolic filling time. This mechanism is particularly beneficial in managing atrial fibrillation by controlling ventricular response rate. The drug's positive inotropic and negative chronotropic effects contribute to its therapeutic value in treating heart failure and certain cardiac arrhythmias.

Cardiac glycoside

Injection

The following are the uses of Digoxin 0.5mg Injection:

• Used for treating heart failure, improving heart function, and controlling symptoms like shortness of breath and swelling.
• Used to restore irregular heart rhythms, particularly atrial fibrillation, helping to regulate the heartbeat.
• Used to strengthen the heart's contractions, improving blood circulation and reducing strain on the heart.
• Used in managing heart conditions where the heart's pumping ability is compromised, enhancing overall heart performance.
• Used to relieve the symptoms of an enlarged heart, reducing the risk of hospitalization.

In the case of an overdose of Digoxin 0.5mg Injection, prompt medical intervention is necessary. Symptoms may include nausea, vomiting, dizziness, and an irregular heartbeat. Medical professionals should be contacted immediately, who can provide appropriate treatment to manage the overdose. This may involve inducing vomiting or administering activated charcoal to prevent further absorption of the medication. Timely action is crucial to minimize potential health risks associated with the overdose.

In the case of a missed dose of Digoxin 0.5mg Injection, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to safely resume your medication without compromising its effectiveness. It is essential to maintain a consistent dosing routine for optimal therapeutic benefits.

To administer Digoxin 0.5mg Injection, carefully inject the prescribed dose subcutaneously or intramuscularly, ensuring proper needle insertion and following the recommended dosage instructions provided by your healthcare professional.

Following are the conditions/situations when Digoxin 0.5mg Injection should not be administered:

• Should not be used in patients with a known allergy to Digoxin or other digitalis glycosides.
• Contraindicated in patients with ventricular fibrillation (a type of abnormal heart rhythm).
• Not recommended for individuals with an untreated hypercalcemia (high blood calcium levels).
• Should not be used in patients with sick sinus syndrome (a type of heart rhythm disorder) unless a functioning pacemaker is present.
• Contraindicated in patients with an AV (atrioventricular) block of the heart's electrical conduction system.
• Not suitable for individuals with a recent myocardial infarction (heart attack) or active inflammation of the heart.
• Should not be used in patients with an untreated hypokalemia (low blood potassium levels).
• Contraindicated in patients with Wolff-Parkinson-White syndrome (a heart condition causing rapid heartbeat).
• Should not be administered to patients with severe respiratory diseases or acute asthma.

The side effects of Digoxin 0.5mg Injection may include:

• Nausea and vomiting
• Loss of appetite
• Diarrhea
• Visual disturbances, such as blurred vision or seeing yellow-green halos around lights
• Confusion and dizziness
• Irregular heart rhythms (arrhythmias)
• Fatigue and weakness
• Skin rash or allergic reactions

Following are the precautions and warnings for Digoxin 0.5mg Injection:

• Patients with kidney or liver disease should be closely monitored as the dosage may need adjustment.
• Elderly patients may be more susceptible to the effects and side effects of this medication, requiring careful monitoring.
• Regular blood tests are necessary to monitor digoxin levels and kidney function to ensure safe usage.
• Inform your doctor about all medications you are taking, especially diuretics, as drug interactions can occur.
• Do not abruptly stop taking Digoxin without medical advice, as it may lead to adverse effects.
• Consult your doctor immediately if you experience symptoms like nausea, vomiting, irregular heartbeat, or confusion during treatment.
• This medication should be used with caution in pregnant and breastfeeding women under medical supervision.

Following are the drug interactions for Digoxin 0.5mg Injection:

• Antibiotics like amoxicillin or tetracycline can decrease digoxin absorption, leading to reduced effectiveness.
• Loop diuretics (e.g., furosemide) and thiazide diuretics may increase digoxin levels, requiring dose adjustments.
• Amiodarone and other drugs that affect the heart's electrical activity can increase the risk of arrhythmias when used with digoxin.
• Digoxin levels may be elevated when taken with macrolide antibiotics (e.g., erythromycin), potentially leading to toxicity.
• Rifampin, a potent enzyme inducer, can decrease digoxin levels, reducing its therapeutic effect.
• Calcium channel blockers, such as verapamil, may increase digoxin concentrations in the blood, requiring close monitoring.
• Certain anti-arrhythmic medications (e.g., quinidine) can interact with digoxin, affecting its elimination and increasing the risk of side effects.

Following are the food interactions to be aware of with Digoxin 0.5mg Injection:

• Consuming high-fiber foods like whole grains, legumes, and certain vegetables can reduce the absorption of Digoxin, leading to decreased effectiveness.
• Avoid excessive consumption of licorice as it may interfere with the electrolyte balance, potentially affecting Digoxin's efficacy.
• Potassium-rich foods such as bananas, oranges, and spinach are essential as Digoxin can deplete potassium levels.
• Limit your intake of foods high in sodium as it may counteract the effects of Digoxin on the heart.
• Avoid large amounts of calcium-rich foods like dairy products as they can reduce Digoxin absorption.
• Grapefruit juice should be consumed cautiously as it may alter Digoxin levels in the blood.
• Alcohol can intensify the effects of Digoxin, leading to increased side effects, so it's best to limit or avoid it.
• Always consult your healthcare provider for personalized advice on diet and Digoxin use.

Digoxin 0.5mg Injection should be stored in a cool and dry place, preferably at room temperature between 68°F and 77°F (20°C and 25°C). Protect the injection from light and moisture by keeping it in its original packaging until ready for use. Avoid storing it in the bathroom or near sinks as exposure to moisture can affect its potency. Always check the expiration date before administration, and never use the injection if it is past its expiry. When disposing of unused or expired Digoxin injections, do not flush them down the toilet or pour them into any water source. Instead, contact your pharmacist or local waste disposal company for instructions on safe disposal methods. Keep the medication out of the reach of children and pets to prevent accidental ingestion.

Following are the quick tips for Digoxin 0.5mg Injection:

• Ensure the injection is administered by a healthcare professional as directed.
• Inform your doctor about all medications you're taking to avoid interactions.
• Report any unusual symptoms or side effects immediately to your healthcare provider.
• Regularly monitor your heart rate and blood pressure as advised by your doctor.
• Store the injection at room temperature, away from direct sunlight and moisture.
• Do not stop or adjust the dose without consulting your healthcare provider.
• Always carry your medication information with you for emergency reference.