Largactil (100mg) 30 Tablets

Chlorpromazine 100mg Tablet primarily exerts its therapeutic effects through multiple mechanisms of action. It acts as a potent antagonist at dopamine receptors, particularly D2 receptors in the brain. By blocking these receptors, chlorpromazine reduces dopamine-mediated neurotransmission in various brain regions. This dopamine blockade is responsible for its antipsychotic properties, as it helps alleviate symptoms associated with psychotic disorders such as schizophrenia. Additionally, chlorpromazine also possesses alpha-adrenergic blocking activity, antihistaminic effects, and anticholinergic properties, which contribute to its sedative, antiemetic, and extrapyramidal side effects. The combined actions of these mechanisms help regulate neurotransmitter activity and restore the balance of certain chemicals in the brain, ultimately leading to the management of psychotic symptoms.

chlorpromazine 100mg

Phenothiazine antipsychotic

Tablet

The following are the uses of chlorpromazine 100mg Tablet:

• Used for treating severe mental health disorders like schizophrenia, helping to manage symptoms such as hallucinations and delusions.
• Used for controlling severe nausea and vomiting, especially in post-surgical or cancer patients.
• Used for managing anxiety and agitation in various mental health conditions.
• Used for short-term control of severe anxiety or excitement, ensuring patient safety.
• Used for alleviating severe itching and hives when other treatments are ineffective.
• Used for treating manic episodes in bipolar disorder, reducing hyperactivity and impulsivity.
• Used for supporting patient comfort and safety during intensive care.

In the case of an overdose of chlorpromazine 100mg tablets, individuals may experience severe side effects such as confusion, drowsiness, and impaired coordination. More serious symptoms can include seizures, slow or irregular heartbeat, and difficulty breathing. It is crucial to seek medical assistance immediately if an overdose is suspected. Prompt treatment can help manage these symptoms and reduce the risk of long-term complications, ensuring the patient's safety and well-being.

In the case of a missed dose of chlorpromazine 100mg Tablet, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for guidance on how to safely resume your medication. It is recommended to set a daily routine or use reminders to help you remember to take your medication as prescribed.

To take Chlorpromazine 100mg Tablet, swallow the tablet whole with a glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare professional, and do not crush, chew, or break the tablet.

Here are the circumstances under which Chlorpromazine 100mg Tablet should be avoided:

• Must not be taken by individuals with a known allergy to chlorpromazine or other phenothiazine drugs.
• Not suitable for patients with severe central nervous system depression or individuals in comatose states.
• Contraindicated in patients with known bone marrow suppression or severe liver damage.
• Should not be used in patients with a history of seizures or epilepsy.
• Avoid use in patients with severe cardiovascular disease or those who have had a recent heart attack.
• Not recommended for individuals with a history of breast cancer or other hormone-sensitive cancers.
• Do not administer to patients with a known blood disorder like porphyria.
• Contraindicated in patients with a history of severe gastrointestinal obstruction.

The side effects of Chlorpromazine 100mg Tablet may include:

• Dizziness and lightheadedness
• Blurred vision
• Dry mouth
• Constipation
• Sedation or drowsiness
• Muscle stiffness or tremors
• Skin rashes or itching
• Restlessness or agitation

Following are the precautions and warnings for Chlorpromazine 100mg Tablet:

• Do not use if you have a known allergy to chlorpromazine or any other phenothiazine medications.
• This medication may cause orthostatic hypotension; caution is required when changing positions to avoid falls.
• Chlorpromazine can lower the seizure threshold; caution should be exercised in patients with a history of seizures.
• May cause drowsiness and dizziness, affecting your ability to drive or operate machinery.
• Elderly patients may be more susceptible to side effects, particularly neurological and cardiovascular effects.
• Avoid alcohol consumption as it can enhance the sedative effects of chlorpromazine.
• Patients with liver or kidney disease should be monitored closely, as dosage adjustments may be necessary.
• Chlorpromazine may cause photosensitivity; limit sun exposure and use protective measures when outdoors.

Following are the drug interactions for Chlorpromazine 100mg Tablet:

• Concomitant use with CNS depressants, such as benzodiazepines, opioids, or alcohol, may enhance sedative effects, leading to increased drowsiness or respiratory depression.
• Anticholinergic drugs, such as atropine, may increase the anticholinergic side effects of chlorpromazine, such as dry mouth, blurred vision, and urinary retention.
• Antihypertensive drugs, such as beta-blockers or ACE inhibitors, may increase the risk of hypotension when combined with chlorpromazine.
• Levodopa and other dopaminergic drugs may reduce the effectiveness of chlorpromazine due to its dopamine receptor-blocking effects.
• Cimetidine may inhibit the metabolism of chlorpromazine, increasing its plasma concentration and the risk of side effects.
• Phenytoin may reduce the effectiveness of chlorpromazine, as it may increase its metabolism.
• Tricyclic antidepressants, such as amitriptyline, may enhance the sedative effects and increase the risk of cardiac arrhythmias when used with chlorpromazine.

Following are the food interactions for Chlorpromazine 100mg Tablet:

• Avoid alcohol consumption as it may enhance the sedative effects of chlorpromazine, leading to increased dizziness and drowsiness.
• Grapefruit and grapefruit juice should be consumed with caution as they can inhibit the enzyme CYP2D6, affecting chlorpromazine's metabolism and potentially increasing its blood levels.
• High-fat meals may delay the absorption of chlorpromazine, possibly reducing its peak concentration in the blood.
• Avoid foods rich in tyramine (aged cheeses, cured meats, fermented foods) as chlorpromazine can interact with tyramine, leading to a potentially dangerous spike in blood pressure.
• Caffeine intake should be limited as chlorpromazine may enhance its effects, causing increased restlessness and anxiety.
• Avoid eating large amounts of high-sodium foods as chlorpromazine can affect sodium levels in the body.
• Inform your healthcare provider about any dietary supplements or herbal products you're taking, as some may interact with chlorpromazine.
• Always follow the dietary advice provided by your healthcare professional for optimal medication effectiveness.

Chlorpromazine 100mg Tablets should be stored in a cool and dry place, preferably at room temperature, ensuring it is protected from light and moisture. Keep the tablets in their original container, tightly sealed, to maintain their integrity and prevent exposure to air. It is crucial not to store them in the bathroom or near heat-emitting appliances as temperature fluctuations can impact the medication's effectiveness. Dispose of any unused or expired tablets responsibly; do not flush them or pour them down the drain. Contact your pharmacist or healthcare provider for guidance on proper disposal methods, and keep all medications out of children's reach to prevent accidental consumption.

Following are the quick tips for Chlorpromazine 100mg Tablet:

• Ensure you have a comprehensive medical evaluation before starting this medication.
• Swallow the tablet whole; do not crush or chew it.
• Take the tablet with a full glass of water to aid in swallowing.
• Adhere to the prescribed dosage and duration as directed by your doctor.
• Avoid alcohol consumption while taking this medication as it may intensify side effects.
• Inform your doctor about all medications you're taking to prevent potential interactions.
• Regularly monitor your progress and report any unusual symptoms to your healthcare provider.