Largactil (25mg) 100 Tablets

Chlorpromazine 25mg tablets act primarily as a dopamine antagonist, particularly at the D2 receptors in various areas of the brain. By blocking dopamine receptors, chlorpromazine reduces dopamine-mediated neurotransmission in the brain's limbic system, reticular formation, and tuberoinfundibular pathway. This mechanism is responsible for its antipsychotic effects. It also exhibits anticholinergic properties by blocking muscarinic acetylcholine receptors, leading to potential side effects associated with this action. Additionally, chlorpromazine's ability to block alpha-adrenergic receptors contributes to its clinical effects and side effect profile. The cumulative blockade of these receptors results in the therapeutic actions of chlorpromazine, primarily in the management of psychotic disorders.

chlorpromazine 25mg

Phenothiazine antipsychotic

Tablet

The following are the uses of chlorpromazine 25mg Tablet:

• Used for treating severe mental health conditions like schizophrenia, helping to manage symptoms such as hallucinations and delusions.
• Used for calming severe anxiety and agitation, especially in manic episodes or severe psychotic disorders.
• Used to control nausea and vomiting, particularly in post-surgery or chemotherapy patients.
• Used for managing persistent hiccups that are resistant to other treatments.
• Used in the rapid control of severe behavioral issues, including violent or aggressive behavior.
• Used to reduce restlessness and overactivity in patients with severe mental disorders.
• Used as a part of a comprehensive treatment plan for Tourette's syndrome to help control tics and involuntary movements.

In the case of an overdose of chlorpromazine 25mg tablets, individuals may experience severe symptoms such as a rapid or irregular heartbeat, low blood pressure, and potential loss of consciousness. Other signs can include muscle stiffness, seizures, and difficulty breathing. It is crucial to seek medical assistance promptly, as these symptoms can be life-threatening. The treatment for an overdose may involve supportive care, monitoring vital signs, and administering specific medications to counteract the effects of chlorpromazine.

In the case of a missed dose of chlorpromazine 25mg Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one. If you have missed multiple doses, consult your healthcare professional for advice on how to safely resume your medication. It is crucial to maintain a consistent medication routine, but if you frequently miss doses, inform your doctor to discuss alternative strategies.

To take Chlorpromazine 25mg Tablets, place the tablet in your mouth and swallow it whole with a glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare professional.

Following are the conditions/situations when Chlorpromazine 25mg Tablet should not be taken:

• Must not be used in patients with a known allergy or hypersensitivity to chlorpromazine or other phenothiazine drugs.
• Contraindicated in patients with a history of bone marrow depression or blood disorders.
• Not suitable for individuals with a history of seizures or epilepsy.
• Should not be used in patients who have experienced a previous episode of liver damage or jaundice due to chlorpromazine.
• Contraindicated during the last stage of labor and delivery due to potential effects on the newborn.
• Not recommended for patients with severe central nervous system depression or comatose states.
• Avoid in patients with severe cardiovascular disorders or a history of heart attacks.
• Must not be used in patients with a known blood clotting disorder or those taking anticoagulant medications.

The side effects of Chlorpromazine 25mg Tablet may include:

• Drowsiness or sedation
• Dry mouth
• Blurred vision
• Constipation
• Dizziness
• Muscle stiffness or tremors
• Skin rashes or itching
• Low blood pressure

Following are the precautions and warnings for Chlorpromazine 25mg Tablet:

• Allergic reactions may occur; patients with a known hypersensitivity to chlorpromazine or related compounds should not take this medication.
• May cause drowsiness and impair judgment; patients should avoid driving or operating heavy machinery until they know how the medication affects them.
• Elderly patients may be more sensitive to the side effects, particularly muscle-related reactions and tardive dyskinesia.
• Blood disorders can occur; regular blood tests are recommended during treatment.
• Liver and kidney function should be monitored regularly as these organs may be affected.
• Avoid alcohol consumption as it can increase the risk of side effects.
• Not recommended for children under 2 years old, and dosage adjustments are necessary for children and adolescents.

Following are the drug interactions for Chlorpromazine 25mg Tablet:

• Alcohol and other central nervous system (CNS) depressants (e.g., opioids, benzodiazepines) can enhance the sedative effects of chlorpromazine, potentially leading to respiratory depression.
• Chlorpromazine may increase the blood levels of lithium, increasing the risk of lithium toxicity. Close monitoring of lithium levels is recommended.
• Concomitant use with other antipsychotics or central anticholinergic medications may increase the risk of side effects such as blurred vision, dry mouth, and constipation.
• Drugs that prolong the QT interval (e.g., certain antiarrhythmics, antibiotics, and antipsychotics) can have additive effects when combined with chlorpromazine, increasing the risk of cardiac arrhythmias.
• Chlorpromazine may lower blood pressure, and combining it with other antihypertensives may result in excessive blood pressure reduction.
• Chlorpromazine may lower the seizure threshold, and its use with anticonvulsants may require adjustment of anticonvulsant dosages.
• Chlorpromazine can inhibit the metabolism of certain medications, including some antidepressants and beta-blockers, potentially leading to increased side effects.

Following are the food interactions for Chlorpromazine 25mg Tablet:

• Avoid drinking alcohol as it can increase the sedative effects, leading to enhanced drowsiness and dizziness.
• Grapefruit and grapefruit juice should be consumed with caution as they may inhibit the enzyme CYP2D6, potentially increasing Chlorpromazine's levels in the blood and the risk of side effects.
• Foods high in fat can affect the absorption of Chlorpromazine, so it is advisable to discuss dietary considerations with your healthcare provider.
• Dairy products, such as milk and yogurt, can potentially interact with Chlorpromazine, reducing its absorption. Separate the medication and dairy intake by a few hours.
• Avoid eating large amounts of high-fiber foods like bran cereals, as they may decrease the absorption of Chlorpromazine.
• Inform your doctor if you have a diet rich in soy products, as they may interfere with Chlorpromazine's metabolism.
• Some herbal supplements, like St. John's Wort, can reduce Chlorpromazine levels, so consult your healthcare provider about any herbal medications you are taking.
• Always follow the advice of your healthcare provider regarding specific dietary restrictions or recommendations while taking Chlorpromazine.

Chlorpromazine 25mg Tablets should be stored in a secure and dry location, preferably in a medicine cabinet, at room temperature (68°F to 77°F). Keep the tablets in their original container, tightly sealed, to maintain their integrity and effectiveness. It is crucial to protect the medication from exposure to light and moisture, so avoid placing it in humid areas like bathrooms or near sinks. Do not store chlorpromazine tablets in the refrigerator or freezer as extreme cold can degrade the medication. Always check the expiration date, and if the tablets are expired or no longer needed, do not throw them into the trash or flush them down the toilet. Consult your pharmacist or healthcare provider for appropriate disposal options to ensure environmental safety. Keep the medication away from children and pets to prevent accidental consumption.

Following are the quick tips for Chlorpromazine 25mg Tablet:

• Take the tablet as directed by your doctor; do not change the dosage without medical advice.
• Ensure you complete the full course of medication, even if you feel better early on.
• Swallow the tablet whole with a full glass of water; do not crush, chew, or break it.
• Maintain a consistent daily routine for taking the medication for best results.
• Inform your doctor about all medications you're taking to avoid potential interactions.
• Store the tablets at room temperature, away from moisture and light.
• Contact your doctor immediately if you experience severe side effects or allergic reactions.