Lastolip EZ (10/10mg) 10 Tablets

Atorvastatin 10mg, Ezetimibe 10mg Tablet has a dual mechanism of action to lower cholesterol levels. Atorvastatin, an HMG-CoA reductase inhibitor, works by competitively inhibiting the enzyme HMG-CoA reductase, which plays a key role in the production of cholesterol in the body. This inhibition reduces the liver's ability to produce cholesterol, leading to decreased levels of total and low-density lipoprotein (LDL) cholesterol. On the other hand, Ezetimibe acts by inhibiting the absorption of cholesterol in the small intestine. It selectively blocks the Niemann-Pick C1-Like 1 (NPC1L1) protein, which is responsible for the uptake of cholesterol from the digestive tract. By reducing cholesterol absorption, Ezetimibe further contributes to lowering LDL cholesterol levels in the bloodstream. The combined effect of these two medications results in a more effective reduction of cholesterol, particularly in individuals who may have difficulty achieving their lipid-lowering goals with statin therapy alone.

Statin and cholesterol absorption inhibitor.

Tablet

The following are the uses of Atorvastatin 10mg, Ezetimibe 10mg Tablet:

• Used for lowering high cholesterol levels
• Used to reduce the risk of heart attacks and strokes in patients with high cholesterol
• Used to manage cholesterol levels in individuals with a family history of heart disease
• Used for treating high cholesterol in patients with diabetes
• Used to prevent cholesterol build-up in blood vessels
• Used for improving blood flow and circulation
• Used to support overall cardiovascular health
• Used alongside lifestyle changes to manage cholesterol-related conditions

In the case of an overdose of Atorvastatin 10mg and Ezetimibe 10mg tablets, it is important to recognize the potential symptoms. These may include muscle pain, tenderness, or weakness, as well as gastrointestinal issues like nausea, diarrhea, and abdominal pain. If an overdose is suspected, seek medical advice promptly. Prompt evaluation and treatment can help manage symptoms and prevent potential complications, ensuring the best possible outcome.

In the case of a missed dose of Atorvastatin 10mg, it is recommended to take the missed dose as soon as you remember, but if it's almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. For Ezetimibe 10mg, if you miss a dose, take it as soon as you remember, but if it's close to the time for your next dose, skip the missed dose and continue with your regular dosing regimen. Do not double the dose to make up for a missed one. It is important to maintain a consistent medication routine, so try to take your medication at the same time each day.

To take the Atorvastatin 10mg, Ezetimibe 10mg Tablet, swallow the tablet whole with a full glass of water once daily, preferably at the same time each day, as directed by your healthcare provider, and it can be taken with or without food.

Following are the conditions or situations when Atorvastatin 10mg, Ezetimibe 10mg Tablet should not be taken:

• Do not take this medication if you are allergic to Atorvastatin, Ezetimibe, or any other similar cholesterol-lowering medications.
• Avoid using this tablet if you have active liver disease or unexplained elevated liver enzymes.
• It is contraindicated in individuals with a history of muscle pain or weakness (myopathy) while taking similar medications.
• Do not take this medication if you are pregnant or breastfeeding, as it may harm the unborn baby or pass into breast milk.
• Should not be used in individuals with a history of severe kidney problems.
• Not recommended for individuals with a history of unexplained elevated creatine phosphokinase (CPK) levels.

The side effects of Atorvastatin 10mg, Ezetimibe 10mg Tablet may include:

• Muscle pain and weakness
• Joint pain
• Diarrhea
• Constipation
• Abdominal pain
• Nausea and vomiting
• Increased liver enzymes
• Fatigue

Following are the precautions and warnings for Atorvastatin 10mg, Ezetimibe 10mg Tablet:

• Individuals with a known allergy to Atorvastatin, Ezetimibe or related medications should not take this tablet.
• Regular liver function tests are recommended while on this medication, especially if there is a history of liver disease.
• Patients with uncontrolled seizures or active liver disease should use this medication with caution and under medical supervision.
• This medication may increase blood sugar levels, so diabetic patients should monitor their blood glucose regularly.
• Patients who consume large amounts of alcohol or have a history of liver disease should inform their doctor before taking this tablet.
• It may cause muscle pain or weakness; report persistent symptoms to your doctor immediately.
• Pregnant or breastfeeding women should consult their doctor as this medication may have potential risks for the fetus or infant.
• Inform your doctor about all medications you are currently taking to avoid potential drug interactions.

Following are the drug interactions for Atorvastatin 10mg, Ezetimibe 10mg Tablet:

• Avoid or use with caution with strong CYP3A4 inhibitors like ketoconazole, clarithromycin, and protease inhibitors, as these can increase atorvastatin levels, leading to increased risk of myopathy and rhabdomyolysis.
• Gemfibrozil, fenofibrate, and other fibrates may increase the risk of myopathy and rhabdomyolysis when used with atorvastatin.
• The effect of ezetimibe may be reduced by cholestyramine and other bile acid sequestrants.
• May increase plasma concentrations of warfarin and other oral anticoagulants, requiring closer monitoring of INR.
• Antacids containing aluminum or magnesium may decrease the absorption of ezetimibe.
• Cyclosporine levels may be increased, requiring monitoring and potential dose adjustment.
• With fenofibrate, there is an increased risk of myopathy and rhabdomyolysis, especially with higher doses of atorvastatin.
• Rifampin may decrease the effectiveness of atorvastatin by inducing CYP3A4.

Following are the food interactions for Atorvastatin 10mg, Ezetimibe 10mg Tablet:

• Grapefruit and grapefruit juice should be avoided as they can increase the blood levels of Atorvastatin, potentially leading to an increased risk of muscle-related side effects.
• Avoid consuming large amounts of alcohol as it can increase the risk of liver-related issues when combined with Atorvastatin.
• Ezetimibe may slightly increase the absorption of fat-soluble vitamins (A, D, E, and K), so monitoring vitamin levels may be necessary.
• Avoid high-fat meals as they can decrease the absorption of Ezetimibe, reducing its effectiveness.
• Avoid consuming large amounts of red yeast rice products as they may contain naturally occurring statins, which can increase the risk of side effects when combined with Atorvastatin.
• Avoid consuming large amounts of dairy products with Ezetimibe as they can interfere with its absorption.
• There is no significant interaction with caffeine, but it's best to consume it in moderation to avoid potential cardiovascular effects.
• Always follow healthcare provider's instructions for any specific dietary restrictions or recommendations.

Atorvastatin 10mg, Ezetimibe 10mg tablets should be stored in a cool and dry place, preferably at room temperature, ensuring protection from light and moisture. Keep the tablets in their original packaging, tightly sealed, to maintain their integrity and prevent exposure to external elements. It is crucial not to store them in the bathroom or near heat sources like ovens or radiators, as temperature fluctuations can impact their effectiveness. Dispose of any unused or expired tablets responsibly; do not flush them or throw them into the garbage. Consult your pharmacist or healthcare professional for guidance on proper disposal methods to ensure environmental safety. Keep the medication out of children's reach to prevent accidental consumption.

Following are the quick tips for Atorvastatin 10mg and Ezetimibe 10mg Tablet:

• Consult your doctor for the right dosage and duration of medication.
• Take the tablet at the same time each day to maintain consistent levels.
• Swallow the tablet whole with a full glass of water.
• Avoid crushing, chewing, or breaking the tablet.
• Do not take with grapefruit juice as it may affect absorption.
• Inform your doctor about all medications you are taking.
• Store in a cool, dry place away from direct sunlight.
• Regularly monitor your cholesterol levels while on this medication.