LECTRUM 7.5MG INJ

Leuprolide Acetate Injection works by mimicking the action of gonadotropin-releasing hormone (GnRH). When administered, it initially stimulates the pituitary gland to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH). However, with continued use, leuprolide causes downregulation of the pituitary GnRH receptors, resulting in decreased secretion of LH and FSH. This leads to a reduction in testosterone production in men and estrogen production in women, which is particularly useful in the treatment of hormone-sensitive conditions such as prostate cancer and endometriosis.

Leuprolide (Acetate)

GnRH agonist

Injection

The following are the uses of Leuprolide (Acetate) Injection:

• Used for treating advanced prostate cancer by reducing testosterone levels
• Used for managing endometriosis by regulating hormone levels
• Used for treating central precocious puberty to help control early puberty symptoms
• Used for managing symptoms of uterine fibroids, reducing their size and associated pain
• Used for treating advanced breast cancer by suppressing estrogen production
• Used for controlling heavy menstrual bleeding in certain conditions
• Used for managing certain types of ovarian cysts and associated symptoms

In the case of an overdose of Leuprolide (Acetate) Injection, it is important to seek medical assistance promptly. Overdose symptoms may include severe allergic reactions, pain, redness, or swelling at the injection site. Immediate treatment should focus on managing these symptoms and providing supportive care. It is crucial to contact a healthcare professional or a poison control center for specific guidance and to address any potential complications arising from the overdose.

In the case of a missed dose of Leuprolide (Acetate) Injection, it is important to act promptly. If you remember within a few hours of the missed dose, administer the injection as soon as possible. However, if a significant amount of time has passed or if it is close to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. Always consult your healthcare provider if you have any concerns or questions regarding missed doses.

To administer Leuprolide (Acetate) Injection, clean the injection site with an alcohol wipe, insert the needle at a 90-degree angle, and slowly inject the medication as directed by your healthcare provider, ensuring the entire dose is delivered under the skin.

Following are the conditions or circumstances when Leuprolide (Acetate) Injection should not be administered:

• Allergic reaction Should not be used if the patient has a known or suspected severe allergic reaction to Leuprolide Acetate or any of the excipients in the injection.
• Pregnancy Contraindicated in pregnant women as it can potentially harm the developing fetus.
• Children Not recommended for use in children, especially for the treatment of pediatric patients with central precocious puberty, unless prescribed by a specialist.
• Undiagnosed vaginal bleeding Should not be initiated in women with undiagnosed abnormal genital bleeding until pathology is ruled out.
• Hormone-related cancers Contraindicated in patients with known or suspected breast or other hormone-dependent cancers.
• Kidney disease Not suitable for individuals with severe kidney impairment or kidney failure.
• Multiple sclerosis Should be avoided in patients with a history of multiple sclerosis as it may worsen symptoms.
• Heart disease Use with caution in patients with heart problems, especially in those with risk factors for cardiovascular disease.

The side effects of Leuprolide (Acetate) Injection may include:

• Flushing or hot flashes
• Night sweats
• Fatigue and weakness
• Headaches
• Joint and muscle pain
• Decreased libido
• Mood changes, including depression or irritability
• Nausea and vomiting

Following are the precautions and warnings for Leuprolide (Acetate) Injection:

• Not suitable for patients with known hypersensitivity to leuprolide or any of its components.
• Caution is required in patients with a history of cardiovascular disease, as leuprolide may cause an increase in blood pressure and potentially affect heart rhythm.
• Leuprolide may cause a flare-up of symptoms in patients with prostate cancer or endometriosis during the first few weeks of treatment. Appropriate monitoring and management are essential.
• Should be used cautiously in patients with osteoporosis, as leuprolide can lead to bone density loss and increased risk of fractures.
• It is not recommended for use during pregnancy or breastfeeding due to potential harm to the fetus or infant.
• Leuprolide may affect the blood sugar levels, so diabetic patients should be monitored closely while using it.
• Long-term use may lead to decreased bone mineral density and should be managed accordingly with calcium and vitamin D supplements or other bone-protective measures.
• The injection may cause local reactions such as pain, swelling, or irritation at the injection site. Seek medical attention if these reactions persist or worsen.
• Use with caution in patients with liver or kidney impairment, as dose adjustments may be necessary.
• Caution is also needed in patients with psychiatric conditions, as leuprolide may contribute to mood changes or depressive symptoms.
• Regular monitoring of hormone levels is necessary during treatment to assess the effectiveness and manage any side effects.
• If signs of an allergic reaction such as difficulty breathing, rash, or swelling occur, seek immediate medical attention.

Following are the drug interactions for Leuprolide (Acetate) Injection:

• Concomitant use with GnRH agonists or antagonists may lead to an additive effect on hormone suppression, potentially causing more pronounced side effects.
• The effectiveness of leuprolide may be reduced when used with medications that increase gonadotropin release, such as clomiphene or certain steroids.
• Leuprolide can interact with opioid pain medications, potentially reducing their effectiveness for pain management.
• Anticoagulants like warfarin may require dose adjustments when used with leuprolide, as it can affect blood clotting.
• When combined with certain anti-cancer drugs, leuprolide may increase the risk of side effects related to bone marrow suppression.
• Caution is advised when using leuprolide with medications that affect kidney function, as it may impact the elimination of these drugs.
• The use of leuprolide with hormonal contraceptives may decrease the effectiveness of contraception, requiring additional birth control methods.

Following are the food interactions to consider with Leuprolide (Acetate) Injection:

• Alcohol consumption should be avoided as it can interfere with the medication's effectiveness and increase the risk of side effects.
• Grapefruit and grapefruit juice should be consumed with caution as they may affect the metabolism of Leuprolide, potentially altering its blood levels.
• High-fat meals might influence the absorption of Leuprolide, so it's advisable to maintain a consistent diet.
• Avoid caffeine-rich beverages as they may interact with Leuprolide, potentially leading to increased heart rate and blood pressure.
• Dairy products containing calcium should be monitored as Leuprolide may decrease calcium levels.
• Limit salt intake as Leuprolide can impact sodium levels.
• Avoid vitamin D supplements unless advised by your doctor, as Leuprolide may lower vitamin D levels.
• Always consult your healthcare provider for personalized dietary advice while using Leuprolide.

Leuprolide (Acetate) Injection should be stored and disposed of with utmost care. It should be kept in a secure location, protected from direct sunlight, and stored at room temperature, preferably between 68°F and 77°F (20°C and 25°C). Avoid freezing the medication as it may affect its potency. Ensure the injection is stored in its original packaging, tightly sealed, to maintain sterility. Do not use the injection if the solution appears discolored or contains particles. When disposing of unused or expired medication, do not throw it in the trash or pour it down the drain. Contact your healthcare provider or pharmacist for guidance on safe disposal methods to prevent any potential harm to the environment.

Following are the quick tips for Leuprolide (Acetate) Injection:

• Administer the injection under the supervision of a healthcare professional for proper administration.
• Ensure the injection is stored at the recommended temperature, usually between 2°C and 8°C (36°F to 46°F).
• Follow the prescribed dosage and treatment duration as advised by your doctor.
• Rotate injection sites to minimize discomfort and reduce the risk of skin reactions.
• Dispose of used needles and syringes safely in designated sharps containers.
• Inform your doctor if you have any allergies or are taking other medications.
• Regularly monitor your health and report any unusual symptoms or side effects to your healthcare provider.