LECZUX SACHETS

The mechanism of action of Macrogol 13.125g and Sodium Chloride 0.3507g in the sachet formulation is primarily focused on osmotic laxative effects. Macrogol, also known as polyethylene glycol, is a non-absorbable osmotic agent that draws water into the bowel, softening the stool and promoting bowel movements. This increased water content in the intestines stimulates peristalsis, aiding in the movement of stool through the colon. Sodium chloride, on the other hand, contributes to the osmotic effect by retaining water in the intestinal lumen, further softening the stool and facilitating easier defecation. The combination of these two components provides a gentle and effective relief from constipation without causing significant fluid or electrolyte shifts in the body.

Osmotic laxative

powder

The following are the uses of Macrogol 13.125g, Sodium chloride 0.3507g Sachet:

• Used for treating constipation, particularly in patients with a history of bowel surgery or ongoing bowel issues.
• Used for emptying the bowels before surgery or certain medical procedures.
• Used for preparing the bowel for diagnostic tests like colonoscopy or barium enema.
• Used for preventing and treating dehydration by helping to restore and maintain fluid and electrolyte balance.
• Used for improving digestion and softening stools, making bowel movements more comfortable.
• Used for managing bowel function in patients with chronic conditions like inflammatory bowel disease.
• Used for short-term relief of constipation in various age groups, including the elderly and children.

In the case of an overdose of Macrogol 13.125g and Sodium Chloride 0.3507g sachets, it is important to seek medical advice promptly. Ingesting excessive amounts may lead to gastrointestinal issues such as nausea, vomiting, and diarrhea. Promptly contact a healthcare professional or a poison control center for guidance on managing symptoms and ensuring proper treatment to address any potential complications.

In the case of a missed dose of Macrogol 13.125g and Sodium Chloride 0.3507g sachet, it is generally recommended to take the missed dose as soon as you remember. However, if it is close to the time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule. It is important not to double the dose to make up for a missed one, as this may lead to excessive bowel movements or dehydration. Consult your healthcare provider if you have any concerns or if you miss multiple doses.

To use Macrogol 13.125g and Sodium Chloride 0.3507g sachet, empty the contents of the sachet into a glass of water, stir well until completely dissolved, and drink the entire mixture, ensuring you consume it all for effective results.

Following are the conditions when Macrogol 13.125g, Sodium chloride 0.3507g Sachet should not be used:

• Do not use if you have a known allergy or hypersensitivity to Macrogol, Sodium Chloride, or any of the excipients in the sachet.
• Not recommended for individuals with severe gastrointestinal conditions such as gastrointestinal obstruction, ileus, or severe colitis.
• Avoid using in patients with severe renal impairment or those undergoing dialysis.
• Should not be used in cases of acute abdominal conditions such as appendicitis or abdominal pain of unknown origin.
• Not suitable for individuals with a history of bowel perforation or recent bowel surgery.
• Contraindicated in patients with severe dehydration; proper rehydration should be considered first.
• Do not administer if the sachet is torn or shows signs of tampering.

The side effects of Macrogol 13.125g and Sodium Chloride 0.3507g Sachet may include:

• Abdominal pain
• Diarrhea or loose stools
• Nausea and vomiting
• Swelling or discomfort in the abdomen
• Gas or flatulence
• Electrolyte imbalances (such as low potassium or sodium levels)
• Skin rashes or itching
• Rare cases of allergic reactions

Following are the precautions and warnings for Macrogol 13.125g, Sodium Chloride 0.3507g Sachet:

• Not suitable for individuals with known hypersensitivity or allergy to Macrogol or Sodium Chloride.
• Patients with kidney disease or impaired renal function should use with caution and under medical supervision.
• May cause electrolyte imbalances, especially in patients with pre-existing electrolyte disturbances. Close monitoring is advised.
• Elderly patients may be more susceptible to side effects; dosage adjustments might be necessary.
• If symptoms persist or worsen, or if abdominal pain, nausea, or vomiting occur, discontinue use and seek medical advice.
• Not recommended for children without medical supervision.
• Pregnant and breastfeeding women should consult a healthcare professional before use to weigh the benefits against potential risks.

Following are the drug interactions for Macrogol 13.125g, Sodium Chloride 0.3507g Sachet:

• Macrogol can decrease the absorption of other medications due to its laxative effect, reducing the time available for drug absorption.
• It may interact with diuretics, as sodium chloride can affect electrolyte balance, and concurrent use might require monitoring.
• The potential for interaction with cardiac medications exists, as sodium chloride can influence blood pressure and fluid balance.
• Antacids containing magnesium or aluminum may reduce the laxative effect of Macrogol.
• Concomitant use with other laxatives should be monitored to avoid excessive electrolyte loss.
• Prolonged use of Macrogol may increase the absorption of certain medications by altering intestinal motility.
• It may affect the absorption of oral medications, especially those with a narrow therapeutic index, requiring careful monitoring.

Following are the food interactions for Macrogol 13.125g, Sodium Chloride 0.3507g Sachet:

• This medication is often used to relieve constipation, so it is essential to maintain a balanced diet with adequate fiber-rich foods like whole grains, fruits, and vegetables.
• Ensure a sufficient intake of fluids, including water, fruit juices, and clear soups, to support the osmotic effect of Macrogol and prevent dehydration.
• Avoid excessive consumption of high-fat foods as they may delay gastric emptying and potentially reduce the effectiveness of the medication.
• Grapefruit and grapefruit juice should be consumed with caution, as they can sometimes interact with medications, although this specific interaction is not well-documented with Macrogol.
• Alcohol consumption should be limited, as it can cause dehydration and potentially worsen constipation, reducing the medication's effectiveness.
• Avoid excessive consumption of dairy products if you are lactose intolerant, as this medication may contain small amounts of lactose.
• No specific food restrictions are required with this medication, but it is always advisable to follow the dietary recommendations provided by your healthcare professional.
• Consult your doctor or pharmacist for personalized advice, especially if you have specific dietary concerns or restrictions.

Macrogol 13.125g and Sodium Chloride 0.3507g sachets should be stored in a cool and dry place, preferably at room temperature, ensuring protection from direct sunlight and moisture. The sachets should remain sealed in their original packaging until use to maintain their integrity. It is crucial to keep this medication away from heat sources like heaters or ovens, as temperature fluctuations can impact its effectiveness. Dispose of any unused or expired sachets responsibly; do not flush them or pour them into drainage systems. Consult your pharmacist for guidance on proper disposal methods, and always keep medicines away from children to prevent accidental consumption.

Following are the quick tips for Macrogol and Sodium Chloride Sachets:

• Mix the contents of the sachet with water as directed to create an oral solution.
• Stir the solution well until all the powder is dissolved before consuming.
• Drink the entire solution, ensuring you consume it within the recommended time frame.
• Stay well-hydrated by drinking plenty of fluids throughout the day.
• If you experience mild nausea, try taking the solution with a light meal or snack.
• Store the sachets in a cool and dry place, away from direct sunlight.
• Consult your healthcare professional if you have any concerns or experience persistent side effects.