Lederrif (600mg) 30 Tablets

Rifampicin 600mg Tablet, a bactericidal antibiotic, exerts its action by inhibiting bacterial RNA polymerase. It binds to the beta-subunit of this enzyme, preventing the formation of the RNA polymerase complex necessary for mRNA synthesis. This disruption in RNA synthesis preferentially affects bacterial cells, as rifampicin can selectively inhibit the bacterial enzyme due to its higher affinity for the bacterial RNA polymerase. By blocking mRNA production, rifampicin inhibits bacterial protein synthesis, which is essential for bacterial growth and survival, ultimately leading to bacterial cell death. This mechanism makes rifampicin a potent antibiotic against a wide range of bacteria, including Mycobacterium tuberculosis.

Rifampicin is an Antibiotic.

Tablet

The following are the uses of Rifampicin 600mg Tablet:

• Used for treating active tuberculosis, especially in combination with other anti-TB drugs.
• Used for preventing the spread of tuberculosis in individuals exposed to the disease.
• Used for treating infections caused by certain bacteria, such as Neisseria meningitidis.
• Used for reducing nasal carriage of meningococcal bacteria in individuals at high risk.
• Used for treating severe acne vulgaris when other treatments have failed.
• Used for prophylaxis against Haemophilus influenzae type b (Hib) infections.
• Used for controlling certain chronic carrier states of bacterial infections.
• Used for treating serious staphylococcal infections, especially in cases of resistance.

In the case of an overdose of Rifampicin 600mg Tablets, several symptoms may occur, including gastrointestinal issues such as nausea, vomiting, and abdominal pain. Additionally, there could be neurological effects like dizziness, headaches, and confusion. It is important to recognize that the severity of these symptoms can vary depending on the amount ingested, and seeking medical advice promptly is essential. Timely intervention and appropriate medical care can effectively manage and treat the adverse effects of a Rifampicin overdose.

In the case of a missed dose of Rifampicin 600mg Tablet, it is important to take the medication as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. However, if you have missed multiple doses or are unsure about what to do, contact your healthcare provider for guidance. They can advise you on how to adjust your dosing schedule to ensure the best treatment outcome.

To take Rifampicin 600mg Tablet, swallow the tablet whole with a full glass of water, preferably on an empty stomach, as directed by your healthcare professional, typically once or twice daily as part of a combination regimen for the treatment of tuberculosis.

Following are the circumstances when Rifampicin 600mg Tablet should not be administered:

• Must not be taken by individuals with a known allergy to Rifampicin or other rifamycin antibiotics.
• Not suitable for individuals with a history of severe liver disease or active liver disorders.
• Contraindicated in patients with a history of porphyria (a disorder affecting certain enzymes in the body).
• Should not be used in individuals with a history of severe kidney disease or those undergoing kidney dialysis.
• Avoid using this medication if you have a history of seizures or epilepsy, as Rifampicin may lower the seizure threshold.
• Do not take Rifampicin if you are breastfeeding, as it can pass into breast milk and may harm the nursing infant.

The side effects of Rifampicin 600mg Tablet may include:

• Skin rash or itching
• Fever
• Nausea and vomiting
• Loss of appetite
• Darkening of urine, sweat, and tears (body fluids)
• Discoloration of contact lenses
• Liver problems (hepatotoxicity)
• Flu-like symptoms (chills, muscle/joint aches)

Following are the precautions and warnings for Rifampicin 600mg Tablet:

• Avoid using Rifampicin if you have a known allergy to Rifampicin or any other rifamycin antibiotics.
• Regular monitoring of liver function is necessary during treatment, especially in patients with pre-existing liver conditions.
• Rifampicin can reduce the effectiveness of hormonal contraceptives; alternative birth control methods are recommended during treatment.
• Patients should be advised to complete the full course of medication as prescribed, even if symptoms improve.
• Rifampicin may cause body fluids and urine to turn reddish-orange, which is usually temporary and harmless.
• This medication may cause live vaccines to be less effective; consult your doctor before receiving any vaccinations.
• Patients with a history of kidney disease should be monitored, as dosage adjustments might be required.
• Rifampicin may interact with other medications, so inform your doctor about all the medicines you are taking.

Following are the drug interactions for Rifampicin 600mg Tablet:

• Rifampicin can reduce the effectiveness of hormonal contraceptives, including birth control pills, patches, and implants, leading to an increased risk of unintended pregnancy.
• It may decrease the plasma concentrations of antiretroviral drugs used to treat HIV/AIDS, such as protease inhibitors and non-nucleoside reverse transcriptase inhibitors.
• Rifampicin induces the metabolism of warfarin, reducing its anticoagulant effect, so monitoring and dose adjustments may be necessary.
• The drug interacts with antiarrhythmic medications like mexiletine, propafenone, and quinidine, potentially reducing their efficacy.
• It can lower the effectiveness of various antibiotics, including ciprofloxacin, doxycycline, and clarithromycin, requiring dose adjustments.
• Rifampicin may reduce the blood levels of antifungal medications like fluconazole and voriconazole, potentially compromising their efficacy.
• Caution is advised when combining with certain antiepileptic drugs as it may lower their plasma concentrations, such as carbamazepine, phenytoin, and valproic acid.

Following are the food interactions for Rifampicin 600mg Tablet:

• Avoid consuming alcohol during treatment with Rifampicin as it may increase the risk of liver toxicity and other adverse effects.
• Grapefruit and grapefruit juice should be consumed with caution as they can affect the metabolism of Rifampicin, potentially altering its effectiveness.
• High-fat meals can delay the absorption of Rifampicin, which may reduce its effectiveness. It is advisable to take the medication on an empty stomach or with a light meal.
• Foods rich in vitamin K, such as leafy green vegetables, should be consumed in moderation as Rifampicin can interfere with vitamin K metabolism, affecting blood clotting.
• Avoid dairy products like milk, cheese, and yogurt within 2 hours of taking Rifampicin as they can bind with the medication and reduce its absorption.
• Limit the consumption of foods high in tyramine, such as aged cheeses, cured meats, and fermented foods, as Rifampicin can interact with tyramine and lead to high blood pressure.
• Certain herbal supplements, like St. John's Wort, may affect the metabolism of Rifampicin and should be used with caution or avoided.
• Always follow the advice of your healthcare provider regarding dietary restrictions and interactions during Rifampicin treatment.

Rifampicin 600mg Tablets should be stored in a cool and dry place, preferably at room temperature, away from direct sunlight and moisture. It is crucial to keep the medication in its original container, tightly sealed, to maintain its integrity and prevent contamination. Ensure you store it away from heat sources like ovens or radiators, as temperature fluctuations can impact the drug's effectiveness. Dispose of any unused or expired tablets responsibly; do not flush them or pour them down the drain. Consult your pharmacist or local waste management guidelines for appropriate disposal methods. Always keep medications out of children's reach to prevent accidental consumption. Regularly check the expiration date, and if the tablets have expired, dispose of them safely.

Following are the quick tips for Rifampicin 600mg Tablet:

• Always take the tablet as directed by your doctor; do not adjust the dosage without medical advice.
• Ensure you complete the full course of medication, even if you feel better early on.
• Take the tablet on an empty stomach, preferably 30 minutes before a meal for optimal absorption.
• Maintain a consistent time for taking the tablet each day to ensure effectiveness.
• Avoid consuming alcohol while on this medication as it may reduce its effectiveness.
• Inform your doctor about all medications you're taking to prevent potential drug interactions.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.