Lederrif (450mg) 30 Tablets

Rifampicin 450mg Tablet primarily acts by inhibiting bacterial RNA polymerase, a crucial enzyme responsible for bacterial RNA synthesis. It binds to the beta-subunit of this enzyme, specifically at the "rifampicin binding site," which is a pocket formed by the enzyme's three-dimensional structure. This binding prevents the RNA polymerase from functioning properly, leading to the inhibition of RNA synthesis. By disrupting RNA synthesis, Rifampicin effectively stops bacterial growth and proliferation, making it a potent antibacterial agent, particularly against rapidly growing bacteria like Mycobacterium tuberculosis.

Antibiotic.

Tablet

The following are the uses of Rifampicin 450mg Tablet:

• Used for treating active tuberculosis, especially in combination with other anti-tuberculosis drugs.
• Used for preventing the spread of tuberculosis in individuals who have been exposed to the bacteria.
• Used for treating infections caused by certain bacteria, including some types of meningitis and nosocomial pneumonia.
• Used for reducing nasal colonization by staphylococci, which can help prevent infections during surgeries.
• Used for treating serious infections caused by specific strains of bacteria when other antibiotics are not effective.
• Used for managing outbreaks of certain bacterial infections, such as meningococcal disease.
• Used for prophylaxis in individuals with weakened immune systems or those at high risk of infection.

In the case of an overdose of Rifampicin 450mg Tablets, it is important to seek medical assistance promptly. Symptoms of overdose may include severe gastrointestinal distress, such as nausea, vomiting, and abdominal pain. Additionally, an overdose can lead to more serious complications, including liver damage and a potentially life-threatening condition called acute liver failure. Timely intervention is crucial to managing these adverse effects and preventing further health risks associated with Rifampicin overdose.

In the case of a missed dose of Rifampicin 450mg Tablet, it is important to take the medication as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. However, if there is ample time before the next dose, take the missed dose right away. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. It is advisable to set a reminder or use a pill organizer to help you remember to take your medication on time to maintain the effectiveness of the treatment.

To take Rifampicin 450mg Tablet, swallow the tablet whole with a full glass of water, preferably on an empty stomach, once daily or as directed by your healthcare professional, ensuring you complete the full course of medication as prescribed.

Here are the conditions or situations when Rifampicin 450mg Tablet should not be taken:

• Avoid using Rifampicin if you have a known allergy or hypersensitivity to Rifampicin or any other rifamycin antibiotics.
• Do not take this medication if you have active liver disease or severe liver impairment.
• Contraindicated in individuals with a history of severe kidney disease or kidney failure.
• Should not be used for the treatment of tuberculosis (TB) when used alone, as it may lead to the development of drug-resistant TB.
• Not recommended for individuals with a history of porphyria, a group of disorders affecting the skin and nervous system.
• Avoid using Rifampicin if you have a history of seizures or epilepsy, as it may lower the seizure threshold.
• Do not use this medication to treat infections other than those caused by susceptible bacteria; it is ineffective against viral infections.
• Contraindicated in patients with a history of gastrointestinal disorders that significantly affect drug absorption.
• Should not be used in individuals with a known sensitivity or reaction to any of the excipients or inactive ingredients in the tablet formulation.

The side effects of Rifampicin 450mg Tablet may include:

• Skin rash or itching
• Fever
• Nausea and vomiting
• Loss of appetite
• Darkening of urine, tears, and sweat
• Yellowing of skin or eyes (jaundice)
• Flu-like symptoms
• Muscle or joint pain

Following are the precautions and warnings for Rifampicin 450mg Tablet:

• This medication may cause discoloration of body fluids, including urine, sweat, and tears, which is a harmless side effect.
• Rifampicin can reduce the effectiveness of hormonal birth control methods, so alternative contraceptive methods are recommended.
• Regular monitoring of liver function is necessary during treatment, especially in patients with pre-existing liver conditions.
• Patients with a history of kidney disease should be monitored, as the dosage may need adjustment.
• Rifampicin may interact with numerous medications, so it is crucial to inform your healthcare provider of all medications you are taking.
• Avoid alcohol consumption as it may increase the risk of liver-related side effects.
• Rifampicin may cause live vaccines to be less effective, so consult your doctor before receiving any vaccinations.
• Discontinue use and seek medical attention if signs of liver problems, such as jaundice, dark urine, or persistent nausea, occur.

Following are the drug interactions for Rifampicin 450mg Tablet:

• Rifampicin induces CYP450 enzymes, reducing plasma levels of many drugs including warfarin, oral contraceptives, and antiretrovirals.
• Combining with CYP3A4 inducers like carbamazepine or phenytoin may further decrease Rifampicin levels.
• Concomitant use with CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin) can increase Rifampicin concentrations.
• May reduce the efficacy of hormonal contraceptives, requiring additional non-hormonal methods.
• Anticonvulsants like phenytoin and carbamazepine may have decreased levels when taken with Rifampicin.
• Rifampicin may lower plasma concentrations of antiretroviral agents, potentially leading to reduced effectiveness.
• Co-administration with antimalarial drugs (e.g., chloroquine) may reduce the efficacy of both medications.

Following are the food interactions to be aware of when taking Rifampicin 450mg Tablets:

• Avoid consuming high-fat meals while taking Rifampicin as it can decrease the absorption of the medication, reducing its effectiveness.
• Grapefruit and grapefruit juice should be consumed with caution as they can alter the metabolism of Rifampicin, potentially affecting its blood levels.
• Limit alcohol intake as Rifampicin may increase the effects of alcohol, leading to increased drowsiness and sedation.
• Avoid dairy products like milk, cheese, and yogurt within 2 hours of taking Rifampicin as calcium can interfere with its absorption.
• Do not consume foods fortified with vitamin K (like green leafy vegetables) in large amounts as Rifampicin can affect blood clotting.
• Be cautious with salt substitutes containing potassium as Rifampicin may increase potassium levels.
• Avoid herbal supplements like St. John's Wort, as it can reduce Rifampicin's effectiveness.
• Always follow healthcare provider's instructions regarding food and medication interactions.

Rifampicin 450mg Tablets should be stored in a cool and dry place, preferably at room temperature, ensuring protection from light and moisture. It is crucial to keep the tablets in their original packaging, tightly sealed, to maintain their integrity. Avoid exposing the medication to direct sunlight or heat sources like radiators, as temperature fluctuations can impact its effectiveness. Dispose of any unused or expired tablets responsibly; do not flush them or throw them into the garbage. Consult your pharmacist or local waste disposal company for guidance on proper disposal methods. Keep this medication securely stored, out of the reach of children and pets, to prevent accidental consumption.

Following are the quick tips for Rifampicin 450mg Tablet:

• Take the tablet as directed by your doctor, usually once daily.
• Swallow the tablet whole with a full glass of water; do not crush, chew, or break it.
• Ensure you complete the full course of medication as prescribed, even if you feel better.
• Rifampicin can cause orange discoloration of urine, sweat, and tears, which is normal.
• Avoid taking antacids or dairy products within 1 hour of taking this medication.
• Inform your doctor about all medications you are taking to prevent potential drug interactions.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.