Lefanor (20mg) 30 Tablets

Leflunomide, a 20mg tablet, primarily exerts its therapeutic effects through the inhibition of dihydroorotate dehydrogenase (DHODH), a crucial enzyme in de novo pyrimidine synthesis. By targeting DHODH, leflunomide disrupts the production of pyrimidine nucleotides, which are essential for the proliferation and function of rapidly dividing cells, particularly lymphocytes. This mechanism leads to a reduction in the number and activity of lymphocytes, resulting in immunosuppression and anti-inflammatory actions. Specifically, leflunomide inhibits the proliferation and activation of T-lymphocytes, which play a central role in the immune response and inflammatory processes. This selective targeting of T-cells underpins the drug's efficacy in managing autoimmune and inflammatory conditions.

Leflunomide 20mg

Immunosuppressant, DMARD (disease-modifying antirheumatic drug).

Tablet

The following are the uses of Leflunomide 20mg Tablet:

• Used for treating rheumatoid arthritis, providing relief from symptoms like joint pain, swelling, and stiffness.
• Used to slow down joint damage and improve physical function in rheumatoid arthritis patients.
• Used for managing moderate to severe cases of psoriasis, reducing skin inflammation and scaling.
• Used to prevent the immune system's overactivity, which is beneficial in autoimmune conditions.
• Used to alleviate joint-related symptoms, enhancing overall mobility and quality of life.
• Used as a long-term treatment option, requiring consistent usage for maximum effectiveness.
• Used under medical supervision, with regular monitoring for optimal results and dosage adjustments.

Follow these dosage instructions:

• Adult Dosage

For patients who are at a low risk for liver disease, start with 100mg once daily for 3 days, then 20mg once daily.

• Child Dosage

The dosage for the child is strictly recommended by the doctor.

In the case of an overdose of Leflunomide 20mg Tablets, it is important to seek medical assistance promptly. Symptoms of an overdose may include severe diarrhea, nausea, and potential liver damage. If a person ingests an excessive amount of this medication, they should be closely monitored for these adverse effects. Quick action and medical intervention can help manage the consequences and ensure the best possible outcome. It is crucial to contact a healthcare professional or poison control center for guidance in such situations.

In the case of a missed dose of Leflunomide 20mg Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for guidance on how to safely resume your medication without affecting its effectiveness. It is generally recommended to take the missed dose within 12 hours of the scheduled time for optimal results.

To take Leflunomide 20mg Tablets, swallow the tablet whole with a full glass of water, preferably at the same time each day, following the prescription instructions provided by your healthcare professional.

Following are the conditions/situations when Leflunomide 20mg Tablet should not be taken:

• Should not be taken by individuals with a known allergy to Leflunomide or any of its ingredients.
• Contraindicated in pregnant women and those who are breastfeeding.
• Not recommended for individuals with severe liver or kidney disease.
• Avoid if you have a severe immune system disorder or an active infection.
• Do not take if you have uncontrolled hypertension or severe cardiovascular disease.
• Leflunomide is not suitable for individuals with severe blood disorders or bone marrow suppression.
• Contraindicated in patients with severe gastrointestinal disorders, such as ulcerative colitis or Crohn's disease.
• Should not be used if you have a history of severe skin reactions or photosensitivity.

The side effects of Leflunomide 20mg Tablet may include:

• Diarrhea
• Nausea and vomiting
• Loss of appetite
• Hair loss
• Skin rash or itching
• Elevated liver enzymes
• High blood pressure
• Respiratory infections

Following are the precautions and warnings for Leflunomide 20mg Tablet:

• Patients with a known hypersensitivity or allergy to Leflunomide or any of its ingredients should not take this medication.
• Regular monitoring of liver function is necessary, and the medication should be discontinued if liver enzyme levels increase significantly.
• It is important to avoid alcohol consumption while taking Leflunomide as it may increase the risk of liver damage.
• Leflunomide may cause birth defects; pregnant women should not handle the tablets. Effective contraception must be used while on this medication.
• Women who are planning to become pregnant must undergo a rapid drug elimination procedure after stopping Leflunomide to reduce the risk of fetal exposure.
• This medication is not recommended for breastfeeding mothers as it may pass into breast milk and harm the infant.
• Patients with severe kidney or liver disease should use Leflunomide with caution and under close medical supervision.
• Leflunomide may increase the risk of infection; patients should be monitored for signs of infection and seek medical attention if symptoms occur.

Following are the drug interactions for Leflunomide 20mg Tablet:

• Avoid alcohol consumption as it may increase the risk of liver toxicity and gastrointestinal side effects.
• Leflunomide may interact with immunosuppressants like cyclosporine, tacrolimus, or mycophenolate, potentially leading to increased immunosuppression and infection risk.
• Concomitant use with other disease-modifying antirheumatic drugs (DMARDs) like methotrexate or sulfasalazine may increase the risk of bone marrow suppression and liver toxicity.
• Taking Leflunomide with nonsteroidal anti-inflammatory drugs (NSAIDs) can increase the likelihood of gastrointestinal side effects and liver problems.
• Cholestyramine can reduce the absorption and effectiveness of Leflunomide by decreasing its reabsorption in the gut.
• Rifampin, a potent inducer of liver enzymes, may decrease Leflunomide's effectiveness by accelerating its metabolism.
• Vaccination with live vaccines should be avoided due to potential immune system impairment.

Following are the food interactions to be aware of when taking Leflunomide 20mg Tablets:

• Alcohol consumption should be avoided as it may increase the risk of liver toxicity and negatively impact the effectiveness of the medication.
• Grapefruit and grapefruit juice should be consumed with caution as they can affect the metabolism of Leflunomide, potentially leading to increased drug levels in the body.
• High-fat meals may delay the absorption of Leflunomide, but this effect is generally not considered clinically significant.
• Avoid cranberry juice as it may decrease the effectiveness of Leflunomide by affecting its metabolism.
• Dairy products like milk and yogurt can potentially interfere with the absorption of Leflunomide, so consider separating them by a few hours.
• Vitamin A and beta-carotene supplements should be used cautiously as Leflunomide may increase their levels in the body.
• Garlic supplements might interact with Leflunomide, so consult your healthcare provider before using them together.
• Consult your pharmacist or healthcare provider for a comprehensive list of foods to avoid or be cautious with while taking Leflunomide.

Leflunomide 20mg Tablets should be stored in a secure and dry location, preferably at room temperature, away from direct sunlight, moisture, and heat sources like ovens or radiators. The original container should be tightly sealed to maintain its integrity and prevent contamination. It is crucial to be mindful of the expiration date on the packaging and to properly dispose of any unused or expired tablets. Avoid flushing or pouring them down the drain; instead, consult a pharmacist or healthcare professional for appropriate disposal guidelines. Ensure that the medication is kept out of children's reach to prevent accidental consumption. These storage and disposal practices are essential to maintain the efficacy and safety of Leflunomide 20mg Tablets.

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Following are the quick tips for Leflunomide 20mg Tablet:

• Take the tablet as directed by your doctor, typically once or twice daily.
• Consume the tablet with a full glass of water, preferably with food.
• Ensure you complete the full course as prescribed, even if you feel better.
• Avoid alcohol consumption while taking this medication.
• Inform your doctor about all medications you are currently taking to prevent potential drug interactions.
• Do not crush or chew the tablet; swallow it whole for optimal absorption.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.
• Regularly monitor your blood work and liver function while on this medication as advised by your healthcare provider.