Lescol (40mg) 28 Capsules

Fluvastatin, a synthetic compound belonging to the statin class of drugs, primarily works by inhibiting HMG-CoA reductase, a crucial enzyme in the mevalonate pathway responsible for cholesterol synthesis. This inhibition significantly reduces the production of cholesterol in the liver, leading to lower levels of low-density lipoprotein (LDL) cholesterol, often referred to as 'bad' cholesterol. By blocking this enzyme, Fluvastatin helps to decrease the amount of cholesterol produced by the body, thereby lowering the risk of cardiovascular events associated with high cholesterol levels. This mechanism makes Fluvastatin a valuable tool in managing hyperlipidemia and reducing the chances of heart disease and stroke.

Fluvastatin 40mg

Statin (HMG-CoA reductase inhibitor)

Capsule

The following are the uses of Fluvastatin 40mg Capsule:

• Used for lowering high cholesterol levels, particularly in individuals with a genetic predisposition to high cholesterol.
• Used for reducing the risk of heart disease and preventing cardiovascular events like heart attacks and strokes.
• Used for managing atherosclerosis, a condition where plaque builds up in the arteries.
• Used for improving blood flow and reducing the risk of blood clots.
• Used for lowering triglyceride levels in the blood, which can contribute to heart disease.
• Used for slowing the progression of coronary artery disease and improving overall heart health.
• Used for treating patients with a history of cardiovascular issues to prevent further complications.

In the case of an overdose of Fluvastatin 40mg Capsules, individuals may experience a range of symptoms. These can include muscle pain, tenderness, or weakness, as well as elevated liver enzymes. Other potential effects may involve gastrointestinal issues such as nausea, vomiting, and abdominal pain. It is crucial to seek medical advice promptly if an overdose is suspected, as appropriate treatment and monitoring can help manage these symptoms effectively.

In the case of a missed dose of Fluvastatin 40mg Capsule, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one. If you miss multiple doses, consult your healthcare professional for advice on how to safely resume your medication without affecting its effectiveness. It is essential to maintain a consistent medication routine for the best therapeutic benefits.

To take Fluvastatin 40mg Capsule, swallow the capsule whole with a full glass of water, preferably in the evening, following the dosage instructions provided by your healthcare professional, and do not crush or chew the capsule to ensure proper absorption.

Following are the conditions or situations when Fluvastatin 40mg Capsule should not be taken:

• Avoid using if you have a known allergy or sensitivity to Fluvastatin or any other statin medications.
• Do not take this medication if you are pregnant or breastfeeding, as it can harm the unborn baby or infant.
• Contraindicated in individuals with active liver disease or unexplained elevated liver enzymes.
• Should not be used if you have a history of muscle pain or weakness, especially if caused by previous statin use.
• Avoid taking Fluvastatin if you have a condition called rhabdomyolysis, which involves the breakdown of muscle fibers.
• Not recommended for individuals with uncontrolled seizures or epilepsy.
• Do not use this medication if you have a severe or uncontrolled infection.
• Contraindicated in patients with kidney disease or impaired kidney function.

The side effects of Fluvastatin 40mg Capsule may include:

• Muscle pain and weakness
• Joint pain
• Nausea and vomiting
• Diarrhea
• Abdominal pain
• Fatigue and tiredness
• Increased liver enzymes (detected in blood tests)
• Allergic reactions (such as rash, itching, or difficulty breathing)

Following are the precautions and warnings for Fluvastatin 40mg Capsule:

• Individuals with a known allergy to Fluvastatin or any of its ingredients should not take this medication.
• Patients with liver disease should use with caution, as regular monitoring of liver function may be necessary.
• Fluvastatin may increase blood sugar levels, so diabetic patients should monitor their blood glucose closely.
• Not recommended for use during pregnancy or breastfeeding unless advised by a healthcare professional.
• Patients with a history of kidney problems should inform their doctor, as dosage adjustments might be required.
• Patients experiencing unexplained muscle pain, tenderness, or weakness should consult their doctor immediately.
• May interact with other medications, including antacids, warfarin, and cyclosporine, so inform your doctor about all medications you are taking.

Following are the drug interactions for Fluvastatin 40mg Capsule:

• Avoid combining with cyclosporine, as it may increase cyclosporine levels and lead to toxicity.
• Rifampin can reduce the effectiveness of Fluvastatin by increasing its metabolism.
• Potent CYP3A4 inhibitors like ketoconazole, itraconazole, and clarithromycin can increase Fluvastatin levels, requiring dose adjustments.
• Gemfibrozil can increase the risk of myopathy and rhabdomyolysis when used with Fluvastatin.
• Anticoagulants like warfarin may have enhanced effects, requiring close monitoring of INR.
• The risk of myopathy may increase when combined with colchicine, requiring caution and regular monitoring.
• Fluvastatin may increase plasma concentrations of certain medications, including verapamil, diltiazem, and amiodarone, potentially requiring dose adjustments.

Following are the food interactions for Fluvastatin 40mg Capsule:

• Grapefruit and grapefruit juice consumption should be avoided as they can significantly increase the levels of Fluvastatin in the blood, leading to potential side effects.
• Limit alcohol intake as it may increase the risk of liver problems and muscle pain, especially when consumed in excess.
• Avoid high-fat meals, as they can decrease the absorption of Fluvastatin, reducing its effectiveness.
• Cranberry juice and products containing cranberry may decrease Fluvastatin's absorption, so it's best to separate them by a few hours.
• Vitamin B3 (Niacin) supplements may increase the risk of muscle problems when taken with Fluvastatin.
• Licorice may decrease the effectiveness of Fluvastatin by inhibiting its metabolism.
• Avoid consuming large amounts of green tea or green tea extracts, as they may interact with Fluvastatin and increase the risk of liver issues.
• Always inform your healthcare provider about your diet and any herbal supplements you're taking to ensure safe and effective use of Fluvastatin.

Fluvastatin 40mg Capsules should be stored in a secure and dry location, preferably in a medicine cabinet, at room temperature (below 25°C). Keep the capsules in their original container, tightly sealed, to maintain their integrity and protect them from moisture and light. It is crucial to ensure that the medication is stored away from children and pets to prevent accidental ingestion. Do not use the capsules if the packaging appears damaged or tampered with. When disposing of unused or expired Fluvastatin capsules, do not throw them into the garbage or flush them down the toilet. Instead, consult your pharmacist or local waste management authority for safe disposal options to minimize environmental impact. Proper storage and disposal practices are essential to maintain the effectiveness of the medication and ensure the safety of others.

Following are the quick tips for Fluvastatin 40mg Capsule:

• Take the capsule as directed by your doctor, usually once daily.
• Swallow the capsule whole with a full glass of water, preferably at the same time each day.
• Take it at night for optimal cholesterol-lowering effects.
• Fluvastatin can be taken with or without food, but taking it consistently with food is advised.
• Avoid grapefruit juice while on this medication as it may affect absorption.
• Inform your doctor about all medications you are taking to prevent potential interactions.
• Regularly monitor your blood cholesterol levels as advised by your healthcare provider.