LEUCOVORIN CA LACHEMA 25 INJ. SICC.

Folic acid, also known as vitamin B9, plays a crucial role in the synthesis of nucleic acids (DNA and RNA) and the metabolism of amino acids. The mechanism of action of folic acid injection is primarily related to its ability to provide a readily available source of this essential vitamin. When administered, folic acid is rapidly absorbed and enters the bloodstream. It then binds to specific receptors on the surface of cells, particularly those in the bone marrow, gastrointestinal tract, and other rapidly dividing tissues. Once inside the cells, folic acid is converted into its biologically active forms, such as tetrahydrofolate (THF) and its derivatives. These active forms serve as coenzymes in various enzymatic reactions, including the synthesis of thymidine, purines, and methionine. By providing the necessary cofactors, folic acid injection supports the rapid cell division and DNA synthesis required for normal growth, development, and the maintenance of various physiological processes. It helps prevent folate deficiency, which can lead to megaloblastic anemia and other health issues.

Folic Acid

Vitamin B9 derivative

Injection

The following are the uses of Folic Acid Injection:

• Used for treating folic acid deficiency, ensuring healthy red blood cell production.
• Used for supporting fetal development during pregnancy, reducing the risk of neural tube defects.
• Used for managing megaloblastic anemia caused by folic acid deficiency.
• Used for improving overall health in individuals with poor dietary folate intake.
• Used for assisting in the absorption of certain medications.
• Used for promoting tissue growth and repair in various medical conditions.
• Used for preventing folic acid deficiency during periods of increased demand, such as pregnancy or lactation.
• Used for enhancing the effectiveness of certain cancer treatments.

In the case of an overdose of Folic Acid Injection, it is important to be aware of potential adverse effects. While rare, excessive intake may lead to gastrointestinal issues such as nausea, abdominal discomfort, and diarrhea. Promptly seek medical advice if any unusual symptoms occur, as individual responses to overdoses can vary. Timely intervention and appropriate medical guidance are essential to address any concerns and ensure patient safety in such instances.

In the case of a missed dose of Folic Acid Injection, it is important to administer the medication as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to safely resume the medication and ensure optimal treatment.

To administer the Folic Acid Injection, clean the injection site with an alcohol wipe, insert the needle at a 90-degree angle, and slowly inject the prescribed dose, ensuring the entire medication is delivered before withdrawing the needle.

Following are the conditions/situations when Folic Acid Injection should be avoided:

• Should not be used in individuals with a known allergy to Folic Acid or any of its components.
• Not recommended for individuals with pernicious anemia, as it is not a substitute for vitamin B12 treatment.
• Contraindicated in patients with untreated or undiagnosed anemia, as it does not treat the underlying cause.
• Avoid using if you have a history of allergic reactions to any vitamins or supplements.
• Not suitable for individuals with rare genetic disorders like an untreated anemias due to folate transport defects (e.g., methylenetetrahydrofolate reductase [MTHFR] deficiency).
• Should not be used in patients with certain types of cancer, especially those undergoing chemotherapy, without medical supervision.
• Avoid using if you have a history of seizures or epilepsy, as high doses of folic acid may affect seizure control.

The side effects of Folic Acid Injection may include:

• Allergic reactions, such as hives, itching, or difficulty breathing.
• Swelling of the face, lips, or tongue.
• Skin reactions at the injection site like pain, redness, or swelling.
• Nausea and vomiting.
• Diarrhea.
• Loss of appetite.
• Metallic taste in the mouth.
• Fatigue or weakness.

Following are the precautions and warnings for Folic Acid Injection:

• Folic Acid Injection should be used with caution in patients with pernicious anemia, as it can mask the symptoms of vitamin B12 deficiency and delay proper diagnosis.
• It is essential to ensure adequate vitamin B12 intake when using this medication to prevent potential complications.
• This medication should only be administered by trained healthcare professionals to avoid potential risks associated with improper injection techniques.

Following are the precautions and warnings for Folic Acid Injection

• Allergy alert

• Do not use if you have a known hypersensitivity or allergy to Folic Acid or any of the excipients in the injection.
• Patients with a history of seizures or epilepsy should be closely monitored, as high doses of Folic Acid may lower seizure thresholds.
• Folic Acid Injection may cause temporary flushing, tingling sensations, or a feeling of body warmth after administration, which is generally mild and self-limiting.

Following are the drug interactions for Folic Acid Injection:

• Antiepileptic medications like phenytoin, phenobarbital, and primidone may reduce the effectiveness of folic acid.
• Folic acid can decrease methotrexate's toxicity in cancer treatment, but this can also reduce its effectiveness.
• Sulfasalazine, a drug for inflammatory bowel disease, can reduce folic acid absorption.
• Folic acid may decrease the effectiveness of pyrimethamine, an antiparasitic medication.
• Folic acid supplementation may interfere with the diagnostic accuracy of serum folate tests.
• Antacids containing zinc may reduce the absorption of folic acid.
• Concomitant use with 5-fluorouracil may increase the toxicity of the latter, especially myelosuppression.

Following are the food interactions for Folic Acid Injection:

• Generally, no specific food interactions are known for Folic Acid injections.
• Folic acid absorption can be hindered by excessive alcohol consumption, so it is advisable to limit alcohol intake.
• Grapefruit juice may interfere with the absorption of certain medications, but its effect on Folic Acid injection is not well-established and may not be significant.
• Consuming a balanced diet rich in natural folate-containing foods, such as leafy green vegetables, legumes, and citrus fruits, can enhance the overall folate status and support the effectiveness of the injection.
• Folic acid supplementation can mask the symptoms of vitamin B12 deficiency, so it's important to ensure adequate B12 intake as well.
• There is no known interaction with caffeine, but excessive caffeine intake should be avoided for overall health.
• Maintaining a healthy diet and staying well-hydrated can support the overall effectiveness of Folic Acid injections.
• Always consult your healthcare provider for personalized advice on dietary considerations related to Folic Acid therapy.

Storage and Disposal of Folic Acid Injection should be carried out with care to ensure its integrity and safety. It is recommended to store the injection in a cool, dry place, preferably at room temperature between 68°F and 77°F (20°C and 25°C). Protect the injection from light and moisture by keeping it in its original packaging until ready for use. Do not freeze the medication as it may affect its potency. Always check the expiration date before administering the injection. For disposal, do not dispose of the injection down the sink, toilet, or in household garbage. Contact your healthcare provider or pharmacist for guidance on proper disposal methods to ensure environmental safety. Keep the injection out of the reach of children and pets to prevent accidental exposure.

Following are the quick tips for Folic Acid Injection:

• Ensure the injection is administered by a trained healthcare professional.
• Confirm the correct dosage and injection site as directed by your doctor.
• Relax and breathe comfortably during the injection to minimize discomfort.
• Avoid touching or reusing needles; dispose of them safely.
• Store the injection as directed; keep it away from light and moisture.
• Inform your doctor if you have any allergies or are taking other medications.
• Report any persistent pain, redness, or swelling at the injection site to your healthcare provider.