Levijon 5ml 5 Injection

L-Ornithine L-Aspartate injection primarily works by promoting the urea cycle and enhancing ammonia detoxification. Ornithine, when combined with aspartate, stimulates the production of urea by providing substrates for the synthesis of arginine and subsequent ammonia incorporation into urea. This mechanism aids in reducing elevated ammonia levels, which is particularly beneficial in conditions where ammonia clearance is compromised, such as hepatic encephalopathy. By facilitating ammonia clearance, L-Ornithine L-Aspartate helps improve neurological symptoms associated with ammonia toxicity.

L-Ornithine, L-Aspartate

Aminosalicylates.

Injection

The following are the uses of L-Ornithine, L-Aspartate injection:

• Used for treating ammonia toxicity in patients with liver disease, helping to reduce the risk of brain damage.
• Used for promoting liver health and supporting the detoxification process.
• Used for managing symptoms of hepatic encephalopathy, improving mental clarity and overall well-being.
• Used for aiding in the removal of waste products, particularly ammonia, from the body.
• Used for enhancing the urea cycle and improving nitrogen metabolism in the body.
• Used for reducing fatigue and improving energy levels in patients with liver cirrhosis.
• Used for supporting overall metabolic function and nutrient utilization.

In the case of an overdose of L-Ornithine, L-Aspartate injection, seek emergency medical care immediately. Symptoms may include nausea, vomiting, abdominal pain, and increased ammonia levels in the blood. Treatment should focus on supportive care, including monitoring vital signs and managing any respiratory or cardiovascular complications. Dialysis may be considered to remove the excess medication from the bloodstream.

In the case of a missed dose of L-Ornithine, L-Aspartate injection, it is important to consult your healthcare provider for guidance. They will advise you on the appropriate course of action, as the decision to administer a missed dose or adjust the dosing schedule depends on various factors. These factors may include the reason for the missed dose, the time elapsed since the last dose, and your overall treatment plan. It is crucial to follow their instructions to ensure the safe and effective use of the medication.

To administer the L-Ornithine, L-Aspartate injection, clean the injection site with an alcohol wipe, insert the needle at a 90-degree angle, and slowly inject the prescribed dose as directed by your healthcare provider, ensuring the entire dose is delivered.

Here are the conditions or situations when L-Ornithine, L-Aspartate injection should not be used:

• Not recommended for individuals with a known hypersensitivity or allergy to L-ornithine, L-aspartate or any of its excipients.
• Contraindicated in patients with severe hepatic encephalopathy or pre-coma.
• Should not be used in individuals with severe kidney disease or those on dialysis.
• Not suitable for patients with metabolic alkalosis.
• Avoid using in patients with urea cycle disorders or severe liver disease.
• L-Ornithine, L-Aspartate injection is not recommended for children under 18 years of age.
• Do not use if you have a history of seizures or epilepsy.

The side effects of L-Ornithine, L-Aspartate injection may include:

• Nausea and vomiting.
• Stomach pain or discomfort.
• Diarrhea.
• Headaches.
• Dizziness or lightheadedness.
• Skin rashes or itching.
• Fatigue or weakness.
• Increased liver enzymes (detected in blood tests).

Following are the precautions and warnings for L-Ornithine, L-Aspartate injection:

• Not suitable for individuals with known hypersensitivity or allergy to L-ornithine, L-aspartate or any of its excipients.
• Patients with hepatic encephalopathy or severe liver impairment should exercise caution and consult a healthcare professional before using this medication.
• Care should be taken to ensure the solution is administered intravenously and not via other routes, as it may cause tissue damage.
• Intravenous administration should be performed slowly, and the patient should be closely monitored for any signs of adverse reactions.
• This medication should not be used in children or adolescents, as its safety and efficacy have not been established in this population.
• Elderly patients may require dosage adjustments and should be monitored closely for adverse effects.
• Pregnant and breastfeeding women should consult their doctor before using this medication, as its safety during pregnancy and lactation has not been fully established.
• L-Ornithine, L-Aspartate injection should be used with caution in patients with kidney disease, as it may need to be adjusted or monitored more frequently.

Following are the drug interactions for L-Ornithine, L-Aspartate injection:

• Concurrent use with other medications that increase ammonia levels, such as valproic acid, may reduce the effectiveness of L-Ornithine, L-Aspartate.
• Alcohol consumption should be avoided as it can increase the risk of neurological side effects.
• Use with medications that affect liver function, such as acetaminophen, should be monitored due to potential additive effects on the liver.
• L-Aspartate may interact with insulin and oral hypoglycemic agents, potentially affecting blood glucose levels.
• Drugs that affect kidney function, like NSAIDs, may impact the excretion of L-Ornithine, L-Aspartate and require close monitoring.
• The injection may influence the effects of medications used for heart failure, such as diuretics, due to its potential fluid-retaining properties.
• Caution is advised when combining with sedatives or central nervous system depressants, as it may enhance their effects.

Following are the food interactions for L-Ornithine, L-Aspartate injection:

• Avoid consuming alcohol with this medication as it may increase the risk of gastrointestinal side effects and affect liver function.
• Caffeine intake should be monitored as it can interfere with the body's absorption of L-ornithine, potentially reducing its effectiveness.
• High-protein foods like meat, fish, and dairy products can enhance the effects of L-ornithine, supporting muscle recovery and growth.
• Consuming foods rich in antioxidants, such as berries, citrus fruits, and leafy greens, can help reduce oxidative stress and support the liver.
• Ensure adequate hydration by drinking plenty of water, as L-ornithine and L-aspartate can act as diuretics, increasing urine production.
• Avoid grapefruit and grapefruit juice as they may affect the metabolism of the medication, potentially altering its effectiveness.
• Limit high-sugar foods and beverages as they can impact the body's amino acid balance and potentially interfere with the medication's effects.
• Consuming foods rich in B-vitamins, especially vitamin B6, can support the body's utilization of L-ornithine and promote overall metabolic health.

L-Ornithine, L-Aspartate injection should be stored in a controlled environment, preferably in a cool and dry place, ensuring it is protected from direct sunlight and moisture. It is crucial to maintain the integrity of the medication by storing it in its original packaging, tightly sealed to prevent contamination. Extreme temperatures should be avoided, so refrain from storing it in hot areas like near a stove or inside a car. Always check the expiration date, and for proper disposal, consult a pharmacist or healthcare professional to ensure safe and environmentally friendly practices. Keep the injection out of children's reach to prevent accidental exposure.

Following are the quick tips for L-Ornithine, L-Aspartate injection:

• Ensure you understand the administration instructions provided by your healthcare professional.
• Check the expiry date before use and do not use if it's expired.
• Use a clean, dry syringe for each injection.
• Inject the medication as instructed, usually into a muscle or as an infusion.
• Rotate injection sites to minimize discomfort and tissue damage.
• Do not mix with other medications unless instructed by your doctor.
• Store the injection as directed, usually at room temperature, away from light and moisture.
• Dispose of used needles and syringes safely in designated sharps containers.