Levra (100mg/ml) 60ml Oral Solution

Levetiracetam is believed to exert its pharmacological action through binding to synaptic vesicle protein 2A (SV2A) in the brain, which is involved in the regulation of synaptic vesicle exocytosis and neurotransmitter release. By binding to SV2A, levetiracetam modulates the release of excitatory neurotransmitters, particularly glutamate, and reduces neuronal hyperexcitability. This mechanism is thought to contribute to its antiseizure effects, as it helps prevent the excessive firing of neurons and the spread of seizure activity. The exact molecular details of how levetiracetam interacts with SV2A and exerts its therapeutic effects are still being studied, but it is known to have a unique mechanism of action compared to other antiepileptic drugs.

Levetiracetam 100mg

Anticonvulsant

Solution

The following are the uses of Levetiracetam 100mg Solution:

• Used for controlling and preventing seizures in adults and children with epilepsy.
• Used for treating partial-onset seizures, both alone and in combination with other medications.
• Used to manage myoclonic seizures associated with juvenile myoclonic epilepsy.
• Used to alleviate primary generalized tonic-clonic seizures.
• Effective for stabilizing mood and reducing the frequency of seizures in patients with bipolar disorder.
• Can be used as a monotherapy or add-on therapy, depending on the patient's condition.

Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• Epilepsy- The dosage can vary between 2000 mg and depending on the other anticonvulsants taken.
• Bipolar mania- The dosage starts at 1000 mg per day and can increase by 1000 mg per week.
• Schizophrenia- This dose ranges from 1000 mg to 1500 mg to 2000 mg per day.
• Distress syndrome- This medication is prescribed 1000-2000 mg daily for 3-4 weeks.

In the case of an overdose of Levetiracetam 100mg Solution, it is important to seek medical advice promptly. Symptoms may include drowsiness, agitation, weakness, and in severe cases, respiratory depression. The severity of the overdose can vary, and immediate medical assessment is necessary to determine the appropriate treatment. Treatment may involve supportive care and managing any resulting symptoms to ensure the patient's safety and well-being.

In the case of a missed dose of Levetiracetam 100mg Solution, it is recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for guidance on how to adjust your medication regimen safely. It is important to maintain a consistent medication routine, but don't worry if you occasionally miss a dose.

To administer Levetiracetam 100mg Solution, use the provided oral syringe to measure the prescribed dose, then squirt the solution into the mouth, ensuring the full dose is swallowed.

Following are the conditions/situations when Levetiracetam 100mg Solution should not be used:

• Must not be taken if you are allergic to levetiracetam or any of the other ingredients in the solution.
• Contraindicated in patients with a history of hypersensitivity or severe reactions to other antiepileptic drugs.
• Not suitable for individuals with severe liver impairment.
• Should be avoided if you have a rare hereditary problem of fructose intolerance.
• Do not administer if the solution is discolored or contains visible particles.
• Do not use if the patient is currently experiencing a severe depressive episode or has a history of major depressive disorder.

The side effects of Levetiracetam 100mg Solution may include:

• Dizziness or drowsiness
• Fatigue and weakness
• Behavioral changes, such as aggression or irritability
• Nausea and vomiting
• Diarrhea or constipation
• Loss of appetite
• Skin rash or itching

Following are the precautions and warnings for Levetiracetam 100mg Solution:

• Do not use if you are allergic to Levetiracetam or any of its ingredients.
• Patients with kidney problems should use with caution and inform their doctor, as dosage adjustments may be necessary.
• Levetiracetam may cause dizziness or drowsiness; avoid driving or operating heavy machinery until you know how the medication affects you.
• Inform your doctor if you have a history of mental health disorders or if you are currently experiencing any psychiatric symptoms.
• Alcohol consumption should be avoided while taking this medication as it may increase the risk of side effects.
• Consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding before using this medication.
• Discontinue use and seek medical attention if you experience any severe or unusual side effects, such as severe rash, difficulty breathing, or unusual changes in mood or behavior.
• Keep out of reach of children and store in a safe place.

Following are the drug interactions for Levetiracetam 100mg Solution:

• Carbamazepine, phenytoin, and other enzyme-inducing antiepileptic drugs may decrease Levetiracetam levels, possibly reducing its effectiveness.
• It can increase the effects of other CNS depressants like opioids, benzodiazepines, and alcohol, leading to enhanced sedation.
• Concomitant use with other antiepileptic drugs like valproic acid may increase the risk of adverse effects, particularly behavioral changes and nervous system disorders.
• May increase the concentration of warfarin, necessitating closer monitoring of INR and potential dose adjustments.
• Theophylline levels may be reduced, requiring monitoring and potential adjustment of theophylline dosage.
• Probenecid may increase Levetiracetam levels, potentially increasing the risk of adverse effects.
• Levetiracetam may alter the efficacy of hormonal contraceptives, requiring additional contraceptive measures.

Following are the food interactions for Levetiracetam 100mg Solution:

• Avoid excessive alcohol consumption as it may increase the sedative effects of Levetiracetam, leading to increased dizziness and drowsiness.
• Grapefruit and grapefruit juice should be consumed with caution. They can alter the blood levels of Levetiracetam by affecting the liver enzymes, potentially affecting the drug's effectiveness.
• No significant food interactions are known to directly impact the absorption of Levetiracetam. However, maintaining a consistent diet is advisable to ensure stable drug levels.
• Avoid high-fat meals as they may affect the absorption rate of Levetiracetam, potentially leading to variations in the drug's effectiveness.
• Caffeine intake should be monitored as it may influence the metabolism of Levetiracetam, potentially affecting its efficacy.
• Always follow the dosage instructions provided by your healthcare professional, especially regarding meal timing and frequency.
• Certain herbal supplements like St. John's Wort may interact with Levetiracetam, so consult your doctor before taking any herbal remedies.
• Inform your healthcare provider about your dietary habits to ensure they provide appropriate guidance regarding Levetiracetam usage.

Levetiracetam 100mg Solution should be stored in a secure and child-resistant container, preferably in a cool and dry place at room temperature, ensuring it remains protected from light and moisture. It is crucial to keep the solution in its original packaging, tightly sealed, to maintain its integrity and prevent contamination. Do not store it in the refrigerator or expose it to freezing temperatures as this may alter its effectiveness. Regularly check the expiration date, and if the solution is past its expiry or no longer needed, proper disposal is essential. Contact your pharmacist or healthcare professional for guidance on safe disposal methods, as flushing or pouring it down the drain should be avoided.

Following are the quick tips for Levetiracetam 100mg Solution:

• Administer the solution as directed by your physician or healthcare professional.
• Ensure accurate dosage measurement using the provided measuring device.
• The solution can be mixed with a small amount of liquid like water or juice to improve taste if needed.
• Consistency is key; take the solution at evenly spaced intervals as prescribed.
• Store the medication at room temperature, away from excessive heat and moisture.
• Always check the expiration date before use, and discard any expired medication.
• Inform your healthcare provider if you have any kidney-related issues for proper dosage adjustment.

Levetiracetam is an anti-seizure medication that is commonly used to treat epilepsy and specific forms of seizures. While it is important to ensure the medication is working safely and effectively, it is crucial to acknowledge that this can lead to an array of side effects. As a result, it is necessary to have lab tests completed in order to monitor the drug's impact on the body. These tests serve as a method of checking for any potential side effects and monitoring the drug levels in the body. More specifically, regular blood tests are often required. These tests are important as they check for elevated levels of liver enzymes and monitor levels of white blood cells, which act as indicators of the medication's impact on the liver and immune system. Likewise, kidney function tests are commonly conducted to assess kidney function and determine if the medication is causing any harm to the kidneys given that it is excreted through these organs. Additionally, doctors may order tests to monitor the concentration of Levetiracetam in the blood to ensure the patient is maintaining a safe and effective level of the medication in their blood. Lastly, long-term use of Levetiracetam may affect the eyes, so eye tests may be required to periodically check for vision-related problems. All these listed tests are imperative to ensure that Levetiracetam is safe to consume and that any concerns are addressed by way of a doctor adjusting the dosage or prescribing additional tests.