Lexidex-M (4/4mg) 60ml Oral Suspension

Levocetirizine in Levocetirizine, Montelukast Sodium Syrup/Suspension is a potent and highly selective antagonist of the H1 histamine receptor, effectively blocking the action of histamine, which is responsible for allergic symptoms. This action helps to reduce symptoms such as sneezing, itching, and nasal congestion. Montelukast Sodium, on the other hand, is a leukotriene receptor antagonist, which inhibits the action of leukotrienes, powerful inflammatory substances involved in allergic reactions. By blocking the leukotriene receptors, Montelukast reduces the inflammation and constriction of airways, thereby preventing asthma and alleviating allergic rhinitis symptoms. The combined effect of these two mechanisms provides comprehensive relief from allergic reactions and is particularly beneficial for patients suffering from both asthma and allergies.

Levocetirizine, Montelukast Sodium

Antihistamine, Leukotriene Receptor Antagonist.

Suspension

The following are the uses of Levocetirizine, Montelukast Sodium Syrup/Suspension:

• Used for relieving symptoms of seasonal allergies, such as runny nose, sneezing, and itching.
• Used for treating allergic rhinitis and reducing nasal congestion.
• Used to manage asthma symptoms and prevent asthma attacks.
• Used for easing symptoms of skin allergies and hives.
• Effective for reducing inflammation in the airways and lungs.
• Used to treat chronic idiopathic urticaria, offering long-term relief.
• Helps in managing symptoms of allergic conjunctivitis.
• Provides relief from respiratory symptoms associated with allergies.

In the case of an overdose of Levocetirizine and Montelukast Sodium Syrup/Suspension, individuals may experience symptoms such as drowsiness, dizziness, rapid or irregular heartbeat, and confusion. It is important to contact a healthcare professional or poison control center immediately for guidance. They can provide specific instructions for managing the overdose, which may include inducing vomiting or administering activated charcoal to prevent further absorption of the medication. Prompt medical attention is necessary to ensure the best possible outcome.

In the case of a missed dose of Levocetirizine, it is generally recommended to take the missed dose as soon as you remember, but if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. For Montelukast Sodium Syrup/Suspension, if a dose is missed, take it as soon as possible, but if it is close to the time for the next dose, skip the missed dose and resume the regular dosing schedule. It is important not to double the dose to make up for a missed one.

To administer Levocetirizine, Montelukast Sodium Syrup/Suspension, shake the bottle well, then measure the prescribed dose using an accurate measuring device like a dosing spoon or oral syringe, and give it to the patient once daily, either with or without food, following the dosage instructions provided by the healthcare professional or as indicated on the medication label.

Here are the conditions or situations when Levocetirizine and Montelukast Sodium Syrup/Suspension should not be taken:

• Not suitable for individuals who have a known allergy or hypersensitivity to Levocetirizine, Montelukast, or any other ingredients in the medication.
• Should not be used in patients with a history of liver or kidney disease, as it may require dosage adjustments.
• Contraindicated in patients with a history of phenylketonuria, as some formulations may contain aspartame.
• Not recommended for individuals with a history of alcohol abuse or liver problems, as Levocetirizine may increase the effects of alcohol.
• Should be avoided in patients with a history of long QT syndrome or other heart rhythm disorders.
• Not suitable for children below 6 months of age for Levocetirizine and 6 years of age for Montelukast, unless prescribed by a doctor.
• Should not be used in patients with a history of acute porphyria.
• Avoid using it in patients with a history of seizures or epilepsy, as it may lower the seizure threshold.

The side effects of Levocetirizine, Montelukast Sodium Syrup/Suspension may include:

• Drowsiness
• Headache
• Dry mouth
• Fatigue
• Throat irritation
• Abdominal pain
• Diarrhea
• Allergic reactions (skin rash, itching)

Following are the precautions and warnings for Levocetirizine, Montelukast Sodium Syrup/Suspension:

• Do not use if you are allergic to Levocetirizine, Montelukast or any other ingredients in the suspension.
• This medication may cause drowsiness, so caution is advised when performing activities that require mental alertness, such as driving or operating machinery.
• Patients with a history of liver or kidney disease should have their liver and kidney function monitored while using this medication.
• It is recommended to avoid alcohol consumption while taking this medication as it may increase the risk of side effects.
• Caution is advised in elderly patients as they may be more susceptible to the side effects of this medication.
• If you have phenylketonuria (PKU), note that some brands of this medication may contain aspartame, which can be harmful.
• Do not exceed the recommended dosage, as it may lead to increased side effects and potential health risks.
• Keep this medication out of reach of children and pets.

Following are the drug interactions for Levocetirizine, Montelukast Sodium Syrup/Suspension:

• Alcohol may enhance drowsiness, so caution is advised when consuming alcohol during treatment.
• Strong CYP3A4 inducers like rifampicin can reduce the effectiveness of levocetirizine.
• Antacids containing aluminum or magnesium may decrease the absorption of montelukast, so a 2-hour gap is recommended between these medications.
• Theophylline levels may increase when taken with montelukast, requiring monitoring and dose adjustments.
• Montelukast may increase the risk of bleeding when used with warfarin, necessitating close monitoring of coagulation parameters.
• Levocetirizine may increase the effects of CNS depressants like benzodiazepines, leading to enhanced sedation.
• Certain medications metabolized by CYP2C8 may have increased blood levels when taken with Levocetirizine, potentially requiring dose adjustments.

Following are the food interactions for Levocetirizine, Montelukast Sodium Syrup/Suspension:

• Grapefruit and grapefruit juice consumption should be avoided as they may increase the concentration of Levocetirizine in the blood, potentially leading to increased side effects.
• Alcohol intake should be minimized or avoided as it can add to the drowsiness caused by Levocetirizine.
• Consuming fatty meals while taking Montelukast may lead to increased absorption and higher blood levels of the medication.
• Avoid drinking fruit juices, especially apple and orange juice, within 4 hours of taking Montelukast as they can reduce its effectiveness.
• Dairy products, like milk and yogurt, can decrease the absorption of Levocetirizine, so it's best to take the medication on an empty stomach.
• Avoid caffeine-rich foods and beverages as they can reduce the sedative effects of Levocetirizine, making it less effective for allergy symptoms.
• There are no significant food interactions with Montelukast, but it's advisable to take it at least 1 hour before or 2 hours after meals for consistent absorption.
• Always follow your healthcare provider's instructions regarding food and medication interactions.

Levocetirizine, Montelukast Sodium Syrup/Suspension should be stored in a secure and dry location, preferably in its original container, away from direct sunlight, moisture, and heat sources like ovens or radiators. It is crucial to maintain the medication at room temperature to preserve its efficacy. Always inspect the expiration date before administering the syrup, and properly dispose of any unused or expired medication. Do not dispose of it via toilet or drainage systems; instead, seek guidance from a pharmacist or healthcare professional for safe disposal practices. Additionally, ensure the medication is kept out of children's reach to prevent accidental consumption. This storage and disposal protocol ensures the medication's integrity and promotes safety within the household.

Following are the quick tips for Levocetirizine, Montelukast Sodium Syrup/Suspension:

• Always consult a doctor for the correct dosage and duration of treatment.
• Ensure you understand the prescription and clarify any doubts with your healthcare provider.
• Administer the syrup/suspension as directed; do not exceed the prescribed dose.
• Shake the bottle well before each use to ensure a homogeneous mixture.
• Use the provided measuring device or a calibrated spoon for accurate dosing.
• Store the medication at room temperature, away from direct sunlight and moisture.
• Regularly monitor and report any side effects or unusual symptoms to your doctor.
• Keep a record of your medication schedule to ensure you don't miss a dose.