LIANE 35 TAB (21S)

Ethinyl estradiol, a synthetic estrogen, primarily works by binding to estrogen receptors in the body, mimicking the effects of natural estrogen. It promotes the development and maintenance of female secondary sexual characteristics and regulates the menstrual cycle. On the other hand, Cyproterone Acetate, a progestin and anti-androgen, blocks the action of androgens by competing with testosterone and dihydrotestosterone (DHT) at androgen receptor sites, reducing their effects on target tissues. This dual action of Ethinyl Estradiol and Cyproterone Acetate helps regulate hormonal imbalances and is often used in combination for specific therapeutic purposes, such as contraception or managing hormonal-related conditions.

Ethinyl Estradiol, Cyproterone Acetate

Oral contraceptive.

Tablet

The following are the uses of Ethinyl Estradiol, Cyproterone Acetate Tablet:

• Used for treating acne in women
• Used for managing hirsutism (excessive hair growth)
• Used for regulating irregular menstrual cycles
• Used for birth control and contraception
• Used for reducing androgen levels in females
• Used for alleviating symptoms of androgen-related conditions
• Used for preventing pregnancy and providing menstrual cycle control
• Used for improving skin texture and reducing oiliness

In the case of an overdose of Ethinyl Estradiol and Cyproterone Acetate tablets, individuals may experience nausea, vomiting, breast tenderness, and in some cases, irregular vaginal bleeding. Symptoms may also include headache, dizziness, and fluid retention. It is important to seek medical advice promptly if an overdose is suspected, as healthcare professionals can provide appropriate guidance and treatment to manage these symptoms effectively.

In the case of a missed dose of Ethinyl Estradiol and Cyproterone Acetate Tablet, it is recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss more than one dose, consult your healthcare provider for advice on how to resume your medication safely.

To take Ethinyl Estradiol, Cyproterone Acetate Tablet, swallow the tablet whole with a glass of water, preferably at the same time each day, following the prescribed dosage and schedule provided by your healthcare professional.

Following are the conditions/situations when Ethinyl Estradiol, Cyproterone Acetate Tablet should not be used:

• Should not be used in individuals with a known allergy or hypersensitivity to Ethinyl Estradiol, Cyproterone Acetate, or any other progestin or estrogen medications.
• Contraindicated in women who are pregnant or planning to become pregnant, as it can cause harm to the developing fetus.
• Not suitable for individuals with a history of blood clots or current thromboembolic disorders, such as deep vein thrombosis (DVT) or pulmonary embolism.
• Should not be used in women with a history of stroke, heart attack, or coronary artery disease.
• Contraindicated in individuals with liver disease, liver tumors, or active liver conditions, as it can worsen liver function.
• Not recommended for those with undiagnosed abnormal genital bleeding or breast cancer.
• Should be avoided by individuals with severe hypertension (high blood pressure) that is uncontrolled.
• Contraindicated in patients with a history of migraine headaches with aura, as it may increase the risk of stroke.
• Not suitable for individuals with diabetes-related complications, such as diabetic retinopathy or nephropathy.

The side effects of Ethinyl Estradiol, Cyproterone Acetate Tablet may include:

• Nausea and vomiting.
• Headaches or migraines.
• Breast tenderness or enlargement.
• Mood changes, including depression or irritability.
• Abdominal pain or bloating.
• Skin changes, such as acne or skin discoloration.
• Changes in menstrual bleeding patterns, including spotting or breakthrough bleeding.
• Increased risk of blood clots, which can lead to serious conditions like deep vein thrombosis (DVT) or pulmonary embolism.

Following are the precautions and warnings for Ethinyl Estradiol, Cyproterone Acetate Tablet:

• This medication should not be used by individuals with a known or suspected estrogen-dependent tumor, such as certain types of breast or uterine cancer.
• Patients with a history of blood clots, stroke, or heart attack should use this medication with caution, as it may increase the risk of these conditions.
• Smoking while taking this medication significantly increases the risk of blood clots and other cardiovascular side effects.
• Patients with a history of liver disease or jaundice should be monitored closely, as this medication can affect liver function.
• It may cause or worsen diabetes, so blood sugar levels should be monitored regularly.
• This medication can impact blood pressure, so regular monitoring is necessary, especially for those with hypertension or other cardiovascular conditions.
• Not recommended for individuals with a history of migraine headaches, as it may increase the frequency and severity of migraines.

Following are the drug interactions for Ethinyl Estradiol, Cyproterone Acetate Tablet:

• Can decrease the effectiveness of lamotrigine, potentially leading to seizures.
• May increase levels of cyclosporine, requiring careful monitoring of cyclosporine levels.
• Concomitant use with St. John's Wort can reduce the efficacy of the contraceptive, increasing the risk of unintended pregnancy.
• Rifampicin and certain antiepileptic drugs like phenytoin and carbamazepine may reduce the effectiveness of this medication as a contraceptive.
• The effectiveness of this drug may be reduced by griseofulvin, increasing the risk of breakthrough bleeding and unintended pregnancy.
• May decrease the plasma concentrations of paracetamol, potentially affecting its therapeutic effect.
• Interactions with hormonal medications like thyroid hormones and corticosteroids may alter their effects and require monitoring.

Following are the food interactions for Ethinyl Estradiol, Cyproterone Acetate Tablet:

• Grapefruit and grapefruit juice should be avoided as they may influence the metabolism of Cyproterone Acetate, potentially increasing its levels in the blood and altering its effectiveness.
• Alcohol consumption may increase the risk of liver-related side effects, especially when combined with Cyproterone Acetate, which can also affect liver function.
• High-fat meals can increase the absorption of Ethinyl Estradiol, potentially leading to higher blood levels and an increased risk of side effects.
• Foods rich in vitamin K, such as leafy green vegetables, should be consumed consistently to maintain stable blood clotting factors, as Ethinyl Estradiol can increase the risk of blood clots.
• Salt and salty foods should be limited as Cyproterone Acetate can cause sodium retention, leading to increased blood pressure.
• Caffeine intake should be monitored as Ethinyl Estradiol may prolong the effects of caffeine, potentially causing jitteriness or increased heart rate.
• A balanced diet is essential, ensuring adequate intake of fiber, proteins, and healthy fats to support overall health while using this medication.
• Always follow dietary recommendations provided by your healthcare professional, especially if you have specific health conditions or concerns.

Ethinyl Estradiol, Cyproterone Acetate Tablets should be stored in a secure and dry location, preferably in a medicine cabinet, away from moisture and heat. It is crucial to keep the tablets in their original packaging or container, tightly sealed, to maintain their integrity and prevent exposure to air and humidity. Do not transfer the medication to another container, as this may compromise its stability. Always check the expiration date, and if the tablets have passed their expiry, dispose of them promptly and responsibly. Proper disposal methods include returning them to a pharmacy or healthcare facility for safe disposal, ensuring they do not end up in the environment or accessible to children or pets. Responsible storage and disposal practices help maintain medication safety and protect the environment.

Here are the quick tips for Ethinyl Estradiol, Cyproterone Acetate Tablet:

• Consult your healthcare provider to determine the appropriate dosage for your specific needs.
• Take the tablet at the same time daily to maintain consistent hormone levels.
• Swallow the tablet whole with a glass of water for easy consumption.
• Avoid crushing or chewing the tablet to ensure proper absorption.
• If you experience mild nausea, taking the tablet with food can help.
• Inform your doctor if you have a history of blood clots or liver problems.
• Store the tablets at room temperature, away from moisture and direct sunlight.
• Always inform your healthcare provider about all medications you are taking.