LIPOCOR 200MG TAB

Bezafibrate 200MG Tablet primarily acts as a pan-peroxisome proliferator-activated receptor (PPAR) agonist, meaning it activates all three types of PPAR receptors alpha, gamma, and delta. This mechanism of action allows Bezafibrate to exert multiple effects on lipid metabolism. It enhances the breakdown of triglyceride-rich particles, reduces very-low-density lipoprotein (VLDL) production in the liver, and increases high-density lipoprotein (HDL) cholesterol levels. Additionally, Bezafibrate decreases the production of apolipoprotein C-III, a protein that inhibits lipoprotein lipase, thereby promoting the clearance of triglyceride-rich particles from the bloodstream. By activating PPARs, Bezafibrate modulates the expression of genes involved in lipid and glucose metabolism, leading to improved lipid profiles and potential benefits in managing dyslipidemia and related metabolic disorders.

Bezafibrate 200MG

Fibrate (lipid-regulating agent).

Tablet

The following are the uses of Bezafibrate 200MG Tablet:

• Used for lowering high cholesterol and triglyceride levels in the blood.
• Used to treat hyperlipidemia, reducing the risk of cardiovascular events like heart attacks and strokes.
• Used to manage dyslipidemia, improving lipid profiles and preventing the formation of fatty deposits in blood vessels.
• Used to treat hypertriglyceridemia, helping to lower elevated triglyceride levels and reduce the risk of pancreatitis.
• Used in combination with lifestyle changes to optimize lipid levels and promote overall cardiovascular health.
• Used for its lipid-modifying effects, especially in patients with metabolic disorders or those at risk of coronary artery disease.
• Used to prevent the progression of atherosclerosis by managing lipid abnormalities.
• Used to enhance the effectiveness of diet and exercise in lipid management.

In the case of an overdose of Bezafibrate 200MG Tablets, individuals may experience a range of symptoms including gastrointestinal distress, such as nausea, vomiting, and abdominal pain. Additionally, there could be an increased risk of liver-related issues, as this medication primarily affects lipid metabolism. It is important to promptly seek medical advice and treatment to manage any potential adverse effects and ensure appropriate care. Immediate consultation with a healthcare professional is essential to address any concerns and determine the necessary steps for treatment.

In the case of a missed dose of Bezafibrate 200MG Tablet, it is advisable to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. It is important not to double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, consult your healthcare professional for guidance on how to safely resume your medication regimen. Always keep a consistent schedule to ensure the medication's effectiveness.

To take Bezafibrate 200MG Tablet, swallow the tablet whole with a full glass of water, preferably with a meal or as directed by your healthcare professional, following the dosage instructions provided by your doctor.

Here are the conditions or situations when Bezafibrate 200MG Tablet should not be taken:

• Avoid using if you have a known allergy to Bezafibrate or any other fibrate medication.
• Do not take this medication if you have severe liver disease or if your liver function tests are significantly abnormal.
• Contraindicated in patients with severe kidney disease or those receiving dialysis.
• Should not be used if you have gallbladder disease, especially if you have gallstones.
• Not suitable for individuals with a history of pancreatitis (inflammation of the pancreas).
• Avoid using this medication if you have a history of muscle disorders or unexplained muscle pain or weakness.
• Do not take Bezafibrate if you are pregnant or breastfeeding, as it may cause harm to the fetus or infant.
• Contraindicated in patients with a history of photosensitivity reactions.

The side effects of Bezafibrate 200MG Tablet may include:

• Stomach pain
• Nausea and vomiting
• Diarrhea
• Headache
• Skin rash or itching
• Muscle pain and weakness
• Increased sensitivity to sunlight
• Abnormal liver function tests

Following are the precautions and warnings for Bezafibrate 200MG Tablet:

• Not recommended for individuals with known allergy or hypersensitivity to Bezafibrate or any of its components.
• Patients with impaired kidney or liver function should exercise caution and consult a doctor, as dosage adjustments may be necessary.
• Bezafibrate may increase the risk of gallstones, so regular monitoring is advised, especially in patients with a history of gallbladder disease.
• It may cause muscle-related side effects, including rhabdomyolysis, so patients should report any unexplained muscle pain, tenderness, or weakness immediately.
• Caution is advised when using Bezafibrate with other fibrate medications or statins, as it may increase the risk of adverse effects.
• Regular monitoring of liver function tests is recommended, and the drug should be discontinued if significant liver enzyme elevations occur.
• Patients with a history of pancreatitis should use Bezafibrate with caution, as it may increase the risk of pancreatitis recurrence.
• Pregnant and breastfeeding women should consult their doctor before taking Bezafibrate, as the risks and benefits should be carefully considered.

Following are the drug interactions for Bezafibrate 200MG Tablet:

• Concomitant use with anticoagulants like warfarin may increase the risk of bleeding and requires close monitoring of coagulation parameters.
• HMG-CoA reductase inhibitors (statins) when used with bezafibrate can lead to an increased risk of rhabdomyolysis and myopathy.
• The effect of bezafibrate may be reduced by bile acid sequestrants, and dosage adjustments might be necessary.
• Bezafibrate can increase the plasma concentration of cyclosporine, requiring close monitoring of cyclosporine levels.
• When used with oral hypoglycemic agents or insulin, bezafibrate may enhance the hypoglycemic effect, necessitating dosage adjustments.
• Corticosteroids may decrease the lipid-lowering effect of bezafibrate.
• The risk of myopathy and rhabdomyolysis may be increased when bezafibrate is combined with colchicine.

Following are the food interactions for Bezafibrate 200MG Tablet:

• Consumption of grapefruit or grapefruit juice should be avoided as it can increase the levels of Bezafibrate in the blood, leading to potential liver toxicity.
• Alcohol intake should be minimized or avoided as it can increase the risk of liver-related side effects.
• Bezafibrate may decrease the absorption of fat-soluble vitamins (A, D, E, and K). Consider supplementing these vitamins under medical supervision.
• High-fat meals can delay the absorption of Bezafibrate, so it's best to take the medication with a low-fat meal or on an empty stomach.
• Avoid excessive consumption of foods rich in Vitamin A, as Bezafibrate may increase its levels in the body.
• Limit the intake of cholesterol-rich foods as Bezafibrate is used to lower cholesterol levels.
• Avoid herbal teas or supplements containing St. John's Wort, as it can reduce the effectiveness of Bezafibrate.
• Always follow the dietary recommendations provided by your healthcare professional while taking Bezafibrate.

Bezafibrate 200MG Tablets should be stored in a cool and dry place, preferably at room temperature, ensuring protection from direct sunlight and moisture. The original packaging should be kept intact, securely sealing the tablets to maintain their integrity and prevent contamination. It is crucial to avoid exposing the tablets to extreme temperatures, so steer clear of storage areas near heat sources like ovens or radiators. Regularly check the expiration date, and dispose of any unused or expired tablets promptly, but never flush them down the toilet or pour them into drainage systems. Consult your pharmacist or healthcare professional for guidance on appropriate disposal methods, and always keep medications securely stored away from children to prevent accidental consumption.

Following are the quick tips for Bezafibrate 200MG Tablet:

• Take the tablet as directed by your doctor, typically once daily with a meal.
• Swallow the tablet whole; do not crush, chew, or break it.
• Consume the tablet with a full glass of water for easier swallowing.
• Maintain a consistent schedule by taking it at the same time each day.
• Do not stop taking the medication without consulting your doctor, even if you feel better.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.
• Inform your doctor about all medications you are taking to prevent potential drug interactions.